The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death

Nah, Jihoon; Zablocki, Daniela; Sadoshima, Junichi

doi:10.1038/s12276-021-00600-3

Cited by 11 publications

(6 citation statements)

References 58 publications

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“…According to the NCCD, autophagic cell death is a regulated form of cell death that relies on autophagy machinery and can be prevented only by blocking autophagy 2 . Autophagic cell death has been implicated in various physiological and pathological processes, including cancer, neurodegeneration, ischemic injury, and heart disease 70 – 74 . However, the precise role of autophagy in cell death is still unclear 16 .…”

Section: Discovery Of Diverse Types Of Cell Deathmentioning

confidence: 99%

Diversity and complexity of cell death: a historical review

Park,

Wei,

Kim

et al. 2023

Exp Mol Med

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Death is the inevitable fate of all living organisms, whether at the individual or cellular level. For a long time, cell death was believed to be an undesirable but unavoidable final outcome of nonfunctioning cells, as inflammation was inevitably triggered in response to damage. However, experimental evidence accumulated over the past few decades has revealed different types of cell death that are genetically programmed to eliminate unnecessary or severely damaged cells that may damage surrounding tissues. Several types of cell death, including apoptosis, necrosis, autophagic cell death, and lysosomal cell death, which are classified as programmed cell death, and pyroptosis, necroptosis, and NETosis, which are classified as inflammatory cell death, have been described over the years. Recently, several novel forms of cell death, namely, mitoptosis, paraptosis, immunogenic cell death, entosis, methuosis, parthanatos, ferroptosis, autosis, alkaliptosis, oxeiptosis, cuproptosis, and erebosis, have been discovered and advanced our understanding of cell death and its complexity. In this review, we provide a historical overview of the discovery and characterization of different forms of cell death and highlight their diversity and complexity. We also briefly discuss the regulatory mechanisms underlying each type of cell death and the implications of cell death in various physiological and pathological contexts. This review provides a comprehensive understanding of different mechanisms of cell death that can be leveraged to develop novel therapeutic strategies for various diseases.

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Section: Discovery Of Diverse Types Of Cell Deathmentioning

confidence: 99%

Diversity and complexity of cell death: a historical review

Park,

Wei,

Kim

et al. 2023

Exp Mol Med

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“…8 Furthermore, Rubicon negatively regulates autophagosome-lysosome fusion by interacting with Beclin-1. 121 It is reported that CXCL10 blocked the fusion of autophagic vesicles with lysosomes through regulating Rubicon. Moreover, genetic inhibition of Rubicon reversed bile acid that induced incomplete autophagy.…”

Section: Beclin-1mentioning

confidence: 99%

“…They demonstrated that the SARS‐CoV‐2‐ORF3a‐UVRAG interaction renders the binding of UVRAG to Beclin‐1 lower competitive than that of ATG14, changes the balance between Beclin‐1‐VPS34‐UVRAG and Beclin‐1‐VPS34‐ATG14 complex, thus promoting more efficient formation of autophagosomes but inhibiting maturation of autophagosome 8 . Furthermore, Rubicon negatively regulates autophagosome‐lysosome fusion by interacting with Beclin‐1 121 . It is reported that CXCL10 blocked the fusion of autophagic vesicles with lysosomes through regulating Rubicon.…”

Section: Signaling Molecules and Pathways Regulating Incomplete Autop...mentioning

confidence: 99%

Incomplete autophagy: Trouble is a friend

Zhang

Cao

Qiu

et al. 2022

Medicinal Research Reviews

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Incomplete autophagy is an impaired self‐eating process of intracellular macromolecules and organelles in which accumulated autophagosomes do not fuse with lysosomes for degradation, resulting in the blockage of autophagic flux. In this review, we summarized the literature over the past decade describing incomplete autophagy, and found that different from the double‐edged sword effect of general autophagy on promoting cell survival or death, incomplete autophagy plays a crucial role in disrupting cellular homeostasis, and promotes only cell death. What matters is that incomplete autophagy is closely relevant to the pathogenesis and progression of various human diseases, which, meanwhile, intimately linking to the pharmacologic and toxicologic effects of several compounds. Here, we comprehensively reviewed the latest progress of incomplete autophagy on molecular mechanisms and signaling pathways. Moreover, implications of incomplete autophagy for pharmacotherapy are also discussed, which has great relevance for our understanding of the distinctive role of incomplete autophagy in cellular physiology and disease. Consequently, targeting incomplete autophagy may contribute to the development of novel generation therapeutic agents for diverse human diseases.

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“… 7 Autophagy contributes to the maintenance of cardiac homeostasis, and the level of autophagy is dynamically altered in heart disease. 8 , 9 Mitophagy, which mediates the selective elimination of dysfunctional mitochondria, is essential for cardiac homeostasis. 10 In cardiomyocytes, mitophagy is closely associated with metabolic activity, cell differentiation, apoptosis, and other physiological processes involved in major phenotypic alterations.…”

Section: Introductionmentioning

confidence: 99%