The roles of progestagen and uterine irritant in the maintenance of cystic endometrial hyperplasia in the canine uterus

Chen, Y.M.M.; Lee, C.S.; Wright, P. J.

doi:10.1016/j.theriogenology.2006.01.019

Cited by 17 publications

(18 citation statements)

References 4 publications

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“…This is associated with a longer period of impact of progesterone on the endometrium during the diestrus [13,38,43]. In the literature, many studies describing abnormal endometrial hyperplasia, in relation to diseases like CEH, mark also a likelihood of its progress to lifethreatening stages [8,33,36,38,39,[42][43][44][45]. Cysts developing in the endometrium classi ed as CEH differ signi cantly in terms of number, size, distribution and histomorphology [36].…”

Section: Discussionmentioning

confidence: 99%

The morphological changes in bitches endometrium affected by Cystic Endometrail Hyperplasia - Pyometra complex – the value of routine histopathological examination

Woźna-Wysocka

Rybska

Błaszak

et al. 2020

Preprint

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Background: The aim of the analysis was to designate the morphological symptoms that appear during the Cystic Endometrial Hyperplasia - Pyometra complex (CEH-P), diagnosed by microscopic examination. The investigation were conducted on the uteri of 120 bitches in age between 1 – 16. The microscopic examinations were based on histological stainings. The aim of examinations was to find the differences in morphology of endometrium in the specimens of the uteri wall (H&E stain). All of the uteri were divided into three pathological groups (GI – GIII), created on the basis of macroscopic examinations of analyzed diseases. Uteri without macroscopic pathological changes were classified as a control group (C).Results: Histopathological analysis that were conducted have confirmed preliminary macroscopic evaluation for control group with unchanged uteri, group GII with cystic endometrial hyperplasia of uteri (CEH), and group GIII with uteri with pyometra. The confirmation of compatibility of both macroscopic and microscopic evaluation of the uteri were observed in groups GII and GIII. In the uteri of the group GI a severe congestion of endometrium have been observed – it is typical for the inflammation – which was not confirmed during histopathological examinations. Those examinations revealed only endometrial haemorrhage.Conclusions: The results are showing that during classification of research material microscopic examinations are required. The diagnose based on the macroscopic changes in typical for CEH-P symptoms might be incorrect, if it is not supported by detailed research. More than that, in all uteri with the closed pyometra the CEH was also observed. It suggest that pyometra may occur as a consequence of cystic endometrial hyperplasia and bacterial infections ended with inflammation. The results obtained can be used to create a basis for pathologic classification of endometrial hyperplasia and indicate typical morphological changes in endometrium during development of CEH-P complex in bitches.

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Section: Discussionmentioning

confidence: 99%

The morphological changes in bitches endometrium affected by Cystic Endometrail Hyperplasia - Pyometra complex – the value of routine histopathological examination

Woźna-Wysocka

Rybska

Błaszak

et al. 2020

Preprint

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“…Repeated progesterone influence during each metoestrus in cycling bitches leads to the gradual development of CEH, fluid accumulation and/or bacterial infection, with the most severe end stage being pyometra. Progesterone, especially after previous oestrogen influence, contributes to the development of disease because the influence of this hormone renders the uterus susceptible to bacterial infection and pyometra (22,23). There are contradictory results regarding the benefit of ovariectomy performed together with mastectomy as well as the connection of abnormal oestrous cycle, false pregnancy, pregnancy, number of litters etc.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Detection of Estrogen Receptors in Canine Mammary Tumors

Petrov¹,

Gjurovski²,

Ristoski³

et al. 2016

Macedonian Veterinary Review

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Short Communication Mac Vet Rev 2016; 39 (1): 117-121 Mammary tumors are among the most common neoplasms in intact female dogs.They have a complex morphology, usually affecting middle age and older bitches. Almost 50% of the mammary tumors in dogs are malignant neoplasms. Prognosis is based on several factors: stage, age, tumor size, metastasis, histopathology, ovariectomy status and hormone-receptor activity. Immunohistochemical (IHC) measurement has become increasingly an important diagnostic and prognostic parameter, with the development of monoclonal antibodies against nuclear estrogen and progestin receptors. The aim of this study was to detect the presence of ER receptors in malignant canine mammary tumors and to identify their association with the clinical course of the tumor. Mammary tumor samples have been obtained by mastectomy from dogs presented at our clinic. Detailed clinical examination, CBC and basic serum biochemical profile were performed in all patients. Surgery was the only treatment. Histopathological examination and immunohistochemical detection of estrogen α receptors (ERα) was performed on 8 formalin-fixed, paraffin-embedded tissue samples, using the PT LINK immunoperoxidase technique. Histopathological examination of the mammary tumor samples (n=11) revealed tubular adenocarcinoma (n=6,54.5%) and ductal adenocarcinoma (n=3, 27.3%), one patient with benign adenoma and one with mastitis. Patients with positive ER tumors are alive, without remission, while 3 of the patients that were ER negative died due to lung metastases. According to our results, it can be concluded that the appearance and development of canine mammary tumors is highly connected with ovarian steroid hormones and that immunostaining of the tumors may be used as a good prognostic parameter in these patients.

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“…Lymphatic cysts are extremely rare in the bitch or queen. Although cystic endometrial hyperplasia (CEH) occurs in both the queen and bitch, it is much more common in the bitch, perhaps because of the longer periods during which the endometrium is under progesterone influence (Chen et al 2006).…”

Section: Cystic Conditions Involving the Endometriummentioning

confidence: 99%

“…This lesion results from marked exuberant growth of the endometrium in either a diffuse or segmental pattern with marked resemblance to the material tissues beneath the normal canine zonary placenta. There is evidence that mild irritation, possibly associated with low-grade bacterial infection, is sufficient to initiate this proliferative chain of events but only when the endometrium is under the influence of progestagens (Nomura and Funahashi 1999;Noakes et al 2001;Chen et al 2006).…”

Section: Cystic Conditions Involving the Endometriummentioning

confidence: 99%

Diseases of the Canine Uterus

Schlafer

2012

Reprod Domestic Animals

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Contents Lesions most commonly found in the canine and feline uteri fall primarily into two categories: (i) abnormalities of endometrial growth and repair and (ii) uterine infections with associated endometritis. Neoplastic conditions of the tubular genitalia of the bitch, with the possible exception of leiomyomas (tumours that arise from smooth muscle cells), are uncommon. Congenital lesions involving the uterus are relatively rare. The primary object of this paper is to provide a summary of the most common uterine lesions found in the canine and feline uterus using a series of images that underscore the most prominent and important gross diagnostic features of each.

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The roles of progestagen and uterine irritant in the maintenance of cystic endometrial hyperplasia in the canine uterus

Cited by 17 publications

References 4 publications

The morphological changes in bitches endometrium affected by Cystic Endometrail Hyperplasia - Pyometra complex – the value of routine histopathological examination

The morphological changes in bitches endometrium affected by Cystic Endometrail Hyperplasia - Pyometra complex – the value of routine histopathological examination

Immunohistochemical Detection of Estrogen Receptors in Canine Mammary Tumors

Diseases of the Canine Uterus

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