The Roles of Phasic and Tonic Dopamine in Tic Learning and Expression

Maia, Tiago V.; Conceição, Vasco A.

doi:10.1016/j.biopsych.2017.05.025

Cited by 62 publications

(82 citation statements)

References 135 publications

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“…Future studies should investigate the striking similarity between theta oscillations in patients with TS and dystonia. In this regard, recent reports propose that phasic and tonic dopamine is increased through striatal hyperinnervation in TS, which may have similar effects as the recently reported increased D1 receptor availability leading to a hyperfunctional direct pathway in patients with dystonia . Moreover, optogenetic activation of D1 receptor‐expressing medium spiny neurons can induce motor stereotypies in rodents .…”

Section: Discussionmentioning

confidence: 66%

Pallidal and thalamic neural oscillatory patterns in tourette's syndrome

Neumann

Huebl

Brücke

et al. 2018

Annals of Neurology

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Section: Discussionmentioning

confidence: 66%

Pallidal and thalamic neural oscillatory patterns in tourette's syndrome

Neumann

Huebl

Brücke

et al. 2018

Annals of Neurology

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“…Another popular pathophysiological hypothesis of TS states a dysfunction of the tonic-phasic dopamine release 57 . The recent model of dopamine function states the regulation of dopamine activity in subcortical regions operates via two mechanisms 58 .…”

Section: Discussionmentioning

confidence: 99%

Striatal dopaminergic alterations in Tourette’s syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies

et al. 2018

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Despite intense research, the underlying mechanisms and the etiology of Tourette’s syndrome (TS) remain unknown. Data from molecular imaging studies targeting the dopamine system in Tourette patients are inconclusive. For a better understanding of the striatal dopamine function in adult dopamine-antagonist-free patients we performed a systematic review in August 2017 identifying 49 PET and SPECT studies on the topic of TS. A total of 8 studies appraised the dopamine transporter (DAT) with 111 Tourette patients and 93 healthy controls, and could be included in a meta-analytic approach. We found a significantly increased striatal DAT binding in Tourette patients (Hedges' g = 0.49; 95% CI: (0.01–0.98)), although this effect did not remain significant after correcting for age differences between cohorts. A second meta-analysis was performed for the striatal dopamine receptor including 8 studies with a total of 72 Tourette patients and 71 controls. This analysis revealed a nonsignificant trend toward lower dopamine 2/3 receptor binding in striatum of Tourette patients. Other analyses regarding study population characteristics in both the DAT and receptor meta-analysis did not show any meaningful results. Our results indicate that dopaminergic alterations in TS are likely and thereby this data would be in line with the current pathophysiological hypotheses of a dysfunction in the dopamine system, e.g., the hypothesis of tonic-phasic dysfunction. However, these analyses suffer from low effect sizes probably due to the heterogeneity of TS and highlight the need for further large-scaled neuroimaging studies.

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“…We modeled participants' trial-by-trial behavior in the stress and control conditions using a reinforcement-learning framework (Sutton & Barto, 1998) that has been extensively used to ACUTE STRESS AND REWARD LEARNING 13 investigate the behavioral and neural impact of pharmacological manipulations and genetic variations in the dopaminergic system in humans (Diederen et al, 2017;Doll et al, 2011;Frank & Fossella, 2011;Frank et al, 2007;Grogan et al, 2017;Rutledge et al, 2009). Importantly, the fitted model included separate learning rates for positive (α + ) and negative (α -) prediction errors, to account both for the differential firing of dopaminergic neurons for positive and negative prediction errors (Daw & Tobler, 2014;Maia & Frank, 2011;Maia & Conceição, 2017) and the differential effects of dopamine onto the plasticity of the corticostriatal synapses implicated in action-value learning (Frank & O'Reilly, 2006;Maia & Frank, 2017;Maia & Conceição, 2017;Möller & Bogacz, 2019). This model also included the inverse temperature parameter, β, which controls the stochasticity of choice selection, or the exploration/exploitation trade-off (Daw, 2011;Sutton & Barto, 1998), as detailed below.…”

Section: Reinforcement-learning Modelmentioning

confidence: 99%

“…One potential neurocognitive explanation for such lack of effect of acute stress on loss avoidance is that D2 dopamine receptors, which mediate punishment learning (Frank & O'Reilly, 2006;Maia & Frank, 2011), are already mostly activated at baseline dopamine levels, so their activation might be affected by decreases, but less so by increases, in dopamine levels (Maia & Conceição, 2017;Möller & Bogacz, 2019). Finally, non-dopaminergic mechanisms may also be involved in punishment learning (Boureau & Dayan, 2011;Moran et al, 2018), which may partially explain why previous studies using the same reinforcement-learning task also did not find significant effects of pharmacological manipulations of the dopaminergic system on punishment learning (Eisenegger et al, 2014;Pessiglione et al, 2006).…”

Section: Effect Of Acute Stress On Punishment Learningmentioning

confidence: 99%

Acute stress impairs reward learning in men

Carvalheiro

Conceição

Mesquita

et al. 2020

Preprint

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Acute stress is ubiquitous in everyday life, but the extent to which acute stress affects how people learn from the outcomes of their choices is still poorly understood. Here, we investigate how acute stress impacts reward and punishment learning in men using a reinforcement-learning task. Sixty-two male participants performed the task whilst under stress and control conditions. We observed that acute stress impaired participants' choice performance towards monetary gains, but not losses. To unravel the mechanism(s) underlying such impairment, we fitted a reinforcement-learning model to participants' trial-by-trial choices. Computational modeling indicated that under acute stress participants learned more slowly from positive prediction errors - when the outcomes were better than expected - consistent with stress-induced dopamine disruptions. Such mechanistic understanding of how acute stress impairs reward learning is particularly important given the pervasiveness of stress in our daily life and the impact that stress can have on our wellbeing and mental health.

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The Roles of Phasic and Tonic Dopamine in Tic Learning and Expression

Cited by 62 publications

References 135 publications

Pallidal and thalamic neural oscillatory patterns in tourette's syndrome

Pallidal and thalamic neural oscillatory patterns in tourette's syndrome

Striatal dopaminergic alterations in Tourette’s syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies

Acute stress impairs reward learning in men

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