The roles of mechanotransduction, vascular wall cells, and blood cells in atheroma induction

Novikova, Olga A.; Laktionov, Pavel P.; Карпенко, А. А.

doi:10.1177/1708538118796063

Cited by 7 publications

(4 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results confirm the data obtained from the optical stretcher [Ekpenyong et al., ]. This process, in which a physical force elicits a functional response, is an example of mechanotransduction [Ekpenyong et al., ; Mennens et al., ; Novikova et al., ].…”

Section: Mechanics In Immunologic Function Of Myeloid Cellssupporting

confidence: 85%

The mechanics of myeloid cells

Bashant

Toepfner

Day

et al. 2020

Biology of the Cell

View full text Add to dashboard Cite

The effects of cell size, shape and deformability on cellular function have long been a topic of interest. Recently, mechanical phenotyping technologies capable of analysing large numbers of cells in real time have become available. This has important implications for biology and medicine, especially haemato-oncology and immunology, as immune cell mechanical phenotyping, immunologic function, and malignant cell transformation are closely linked and potentially exploitable to develop new diagnostics and therapeutics. In this review, we introduce the technologies used to analyse cellular mechanical properties and review emerging findings following the advent of high throughput deformability cytometry. We largely focus on cells from the myeloid lineage, which are derived from the bone marrow and include macrophages, granulocytes and erythrocytes. We highlight advances in mechanical phenotyping of cells in suspension that are revealing novel signatures of human blood diseases and providing new insights into pathogenesis of these diseases. The contributions of mechanical phenotyping of cells in suspension to our understanding of drug mechanisms, identification of novel therapeutics and monitoring of treatment efficacy particularly in instances of haematologic diseases are reviewed, and we suggest emerging topics of study to explore as high throughput deformability cytometers become prevalent in laboratories across the globe.

show abstract

Section: Mechanics In Immunologic Function Of Myeloid Cellssupporting

confidence: 85%

The mechanics of myeloid cells

Bashant

Toepfner

Day

et al. 2020

Biology of the Cell

View full text Add to dashboard Cite

show abstract

“…[107,108] In combination with nanomaterial-based CAs, the utilization of MR imaging allows for the enhanced visualization of atherosclerotic plaques, facilitating their diagnostic assessment by augmenting r 1 longitudinal relaxation and r 2 transverse relaxation. [109][110][111][112][113] For example, Yamakoshi et al developed A) Schematic illustration of the surface hydrolysis-designed AuNPs-zwit-glucose for precise detection of macrophages and targeting infarcted lesions. Reproduced with permission.…”

Section: Magnetic Resonance (Mr) Imagingmentioning

confidence: 99%

“…[ 107,108 ] In combination with nanomaterial‐based CAs, the utilization of MR imaging allows for the enhanced visualization of atherosclerotic plaques, facilitating their diagnostic assessment by augmenting r 1 longitudinal relaxation and r 2 transverse relaxation. [ 109–113 ] For example, Yamakoshi et al. developed LDL‐mimetic lipid nanoparticles (LNPs) with apolipoprotein‐mimetic peptide (P) and Gd(III)‐chelate using the amide‐forming potassium acyltrifluoroborate (KAT) ligation reaction.…”

Section: Nanoplatform Developed For As Imagingmentioning

confidence: 99%

Engineering Nanoplatforms for Theranostics of Atherosclerotic Plaques

Liu,

Jiang,

Yang

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Atherosclerotic plaque formation is considered the primary pathological mechanism underlying atherosclerotic cardiovascular diseases, leading to severe cardiovascular events such as stroke, acute coronary syndromes, and even sudden cardiac death. Early detection and timely intervention of plaques are challenging due to the lack of typical symptoms in the initial stages. Therefore, precise early detection and intervention play a crucial role in risk stratification of atherosclerotic plaques and achieving favorable post‐interventional outcomes. The continuously advancing nanoplatforms have demonstrated numerous advantages including high signal‐to‐noise ratio, enhanced bioavailability, and specific targeting capabilities for imaging agents and therapeutic drugs, enabling effective visualization and management of atherosclerotic plaques. Motivated by these superior properties, we comprehensively summarize various noninvasive imaging modalities for early recognition of plaques in the preliminary stage of atherosclerosis. Additionally, we propose several therapeutic strategies to enhance the efficacy of treating atherosclerotic plaques. Finally, we discuss existing challenges and promising prospects for accelerating clinical translation of nanoplatform‐based molecular imaging and therapy for atherosclerotic plaques. In conclusion, this review provides an insightful perspective on the diagnosis and therapy of atherosclerotic plaques.This article is protected by copyright. All rights reserved

show abstract

“…Inflammatory cytokines TNF‐α and IL‐1 trigger an increase in vSMC ICAM‐1, IL‐6, and MMPs. For example, the increase of ICAM‐1 can improve the monocyte/macrophage and T‐cell adhesion to cells, converting vSMCs from a contractile phenotype to their synthetic phenotype, and spurring atherosclerotic buildup/plaques (Novikova et al, 2019).…”

Section: Disturbed Flow and Vascular Remodelingmentioning

confidence: 99%

Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review

Sunderland

Jiang

Zhao

2021

Journal Cellular Physiology

View full text Add to dashboard Cite

Aneurysms are malformations within the arterial vasculature brought on by the structural breakdown of the microarchitecture of the vessel wall, with aneurysms posing serious health risks in the event of their rupture. Blood flow within vessels is generally laminar with high, unidirectional wall shear stressors that modulate vascular endothelial cell functionality and regulate vascular smooth muscle cells. However, altered vascular geometry induced by bifurcations, significant curvature, stenosis, or clinical interventions can alter the flow, generating low stressor disturbed flow patterns. Disturbed flow is associated with altered cellular morphology, upregulated expression of proteins modulating inflammation, decreased regulation of vascular permeability, degraded extracellular matrix, and heightened cellular apoptosis. The understanding of the effects disturbed flow has on the cellular cascades which initiate aneurysms and promote their subsequent growth can further elucidate the nature of this complex pathology. This review summarizes the current knowledge about the disturbed flow and its relation to aneurysm pathology, the methods used to investigate these relations, as well as how such knowledge has impacted clinical treatment methodologies. This information can contribute to the understanding of the development, growth, and rupture of aneurysms and help develop novel research and aneurysmal treatment techniques.

show abstract

The roles of mechanotransduction, vascular wall cells, and blood cells in atheroma induction

Cited by 7 publications

References 102 publications

The mechanics of myeloid cells

The mechanics of myeloid cells

Engineering Nanoplatforms for Theranostics of Atherosclerotic Plaques

Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review

Contact Info

Product

Resources

About