The roles of kisspeptin and gonadotropin inhibitory hormone in stress-induced reproductive disorders

Iwasa, Takeshi; Matsuzaki, Takashi; Yano, Kiyohito; Mayila, Yiliyasi; Irahara, Minoru

doi:10.1507/endocrj.ej18-0026

Cited by 38 publications

(34 citation statements)

References 91 publications

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“…Neuroendocrine sex differences in regulation of eating behavior have been thoroughly reviewed (110, 111). Recently discovered hypothalamic peptides kisspeptin, gonadatropin-inhibitory peptide and amide-related peptide-3 all seem to be involved in the genesis of stress-induced hypothalamic amenorrhea (112), but their potential role in AN remains uncertain.…”

Section: Hypothalamic–pituitary–gonadal Axismentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update

Støving

2019

European Journal of Endocrinology

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Anorexia nervosa is a syndrome, that is collections of symptoms, which is not defined by its etiology. The severe cases are intractable. The syndrome is associated with multiple, profound endocrine alterations which may be adaptive, reactive or etiologic. Adaptive changes potentially may be inappropriate in clinical settings such as inpatient intensive re-nutrition or in a setting with somatic comorbidity. Electrolyte levels must be closely monitored during the refeeding process, and the need for weight gain must be balanced against potentially fatal refeeding complications. An important focus of clinical research should be to identify biomarkers associated with different stages of weight loss and re-nutrition combined with psychometric data. Besides well-established peripheral endocrine actions, several hormones also are released directly to different brain areas, where they may exert behavioral and psychogenic actions that could offer therapeutic targets. We need reliable biomarkers for predicting outcome and to ensure safe re-nutrition, however, first of all we need them to explore the metabolism in anorexia nervosa to open new avenues with therapeutic targets. A breakthrough in our understanding and treatment of this whimsical disease remains. Considering this, the aim of the present review is to provide an updated overview of the many endocrine changes in a clinical perspective.

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Section: Hypothalamic–pituitary–gonadal Axismentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update

Støving

2019

European Journal of Endocrinology

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“…Moreover, some studies have suggested a positive correlation between kisspeptin and LH secretory pulses [ 10 ]. Kisspeptin may also influence the negative and positive feedback of estrogen [ 11 ]. Many reports have emphasized the sensitivity of kisspeptin to the metabolic state of the body and to stress, both acute and chronic [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Kisspeptin may also influence the negative and positive feedback of estrogen [ 11 ]. Many reports have emphasized the sensitivity of kisspeptin to the metabolic state of the body and to stress, both acute and chronic [ 10 , 11 ]. It was reported that the higher the cortisol level is, the lower the plasma level of kisspeptin will be [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Has Menstruation Disappeared? Functional Hypothalamic Amenorrhea—What Is This Story about?

2021

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Functional hypothalamic amenorrhea (FHA) is a very common condition affecting women of procreative age. There are many reasons for this disorder, including a low availability of energy in the diet, low micro- and macronutrient intake, overly intensive physical activity, disturbed regeneration processes, sleep disorders, stress, and psychological disorders. The main determinant is long-term stress and an inability to handle the effects of that stress. FHA is a very complex disorder and often goes undiagnosed. Moreover, therapeutic interventions do not address all the causes of the disorder, which could have implications for women’s health. As shown by scientific reports, this condition can be reversed by modifying its causes. This review of the literature aims to update the current knowledge of functional hypothalamic amenorrhea and underscores the complexity of the disorder, with particular emphasis on the nutritional aspects and potential interventions for restoring balance.

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“…[18, 27, 29]. Growing evidence indicated that gonadotropin inhibitory hormone (GnIH) also play pivotal roles in the stress-induced disruption of the hypothalamus-pituitary-gonadal axis [5, 12].…”

Section: Discussionmentioning

confidence: 99%

Pre-pubertal exposure to high temperature impairs ovarian and adrenal gland function in female rats

Zheng

Nagaoka

Watanabe

2019

The Journal of Veterinary Medical Science

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The influence of different levels of heat exposure on the functions of ovarian and adrenal gland were investigated in pre-puberty female rats. Three-week old female rats were treated with control (26°C) or three higher temperatures (38, 40 and 42°C) for 2hr/day. After 9 days of treatment, blood samples were collected for measurement of luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol-17β, corticosterone, cholesterol and triglyceride. Adrenal glands, ovaries and liver were collected for analyzing gene expressions. Body and liver weight were significantly low in the 42°C heating group. Circulating LH and triglyceride in the 42°C heating group were significantly lower, and estradiol-17β, corticosterone and cholesterol were significantly higher than those of the control group. The gene expression of 3β-HSD and P450c21 in the adrenal gland; 3β-HSD, receptors of LH, FSH and estrogen in the ovary were significantly low in heated rats. The liver gene expressions of caspase 3 and NK-κB were significantly high in 42°C heated rats, suggesting that the ability of liver metabolic function reduced in the 42°C heated rats. These results demonstrated that the high temperature is responsible for suppression of ovarian function by decreasing the expression of steroidogenic enzymes, estrogen and gonadotropin receptors in the ovary. Increase in circulating estradiol-17β in the heated rats may be due to accumulate this hormone in circulation by potential changes in liver metabolism during the heat stress.

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The roles of kisspeptin and gonadotropin inhibitory hormone in stress-induced reproductive disorders

Cited by 38 publications

References 91 publications

MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update

MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update

Has Menstruation Disappeared? Functional Hypothalamic Amenorrhea—What Is This Story about?

Pre-pubertal exposure to high temperature impairs ovarian and adrenal gland function in female rats

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