The roles of ions on bone regeneration

O’Neill, Edward; Awale, Guleid; Daneshmandi, Leila; Umerah, Obum; Lo, Kevin W.‐H.

doi:10.1016/j.drudis.2018.01.049

Cited by 295 publications

(194 citation statements)

References 110 publications

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“…The synthesized pure stoichiometric HAP: Ca 10 (PO 4 ) 6 (OH) 2 and Sr substituted hydroxyapatites. HAP-Sr: SrHAP: Sr 10 (PO 4 ) 6 (OH) 2 ; HAP-5%Sr: Ca 9.41 Sr 0.59 (PO 4 ) 6 (OH) 2 ; HAP-10% Sr: Ca 8.79 Sr 1.21 (PO 4 ) 6 (OH) 2 ; and HAP-15% Sr: Ca 8.13 Sr 1.87 (PO 4 ) 6 (OH) 2 , correspond to the general formula Ca 10-x Sr x (PO 4 ) 6 (OH) 2 .…”

Section: Results and Discussion Hap And Hap-sr Substrates (Scaffolds)mentioning

confidence: 99%

“…The healing of fractures requires the use of biocompatible materials with specific physical and chemical properties as well as osteoconductive and bone regeneration capacity [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. In orthopedic surgery, a more difficult situation is associated with bone fragility, like osteoporosis [17,18], where a special attention is required concerning the selection of the graft material.…”

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confidence: 99%

“…Furthermore, the increasing interest in the development of bio-ceramics based on synthetic hydroxyapatite (HAP) and substituted HAP with various essential elements, such as Mg, Zn, Si and Sr [4][5][6][7][8][9][10][11][12][13][14][15][16] and especially for Sr substituted HAP (HAP-Sr) [11][12][13][22][23][24][25][26][27][28], for bone repair is justified by the growing evidence of Sr beneficial effect on bone regeneration [2,17,20].…”

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confidence: 99%

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In vitro Response of Human Osteoblasts Cultured on Strontium Substituted Hydroxyapatites

Răpuntean¹,

Frangopol²,

Hodisan³

et al. 2019

Rev. Chim.

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The goal of this study was to analyze the response of osteoblasts cultured on strontium substituted hydroxyapatites (HAP-Sr) of well-defined high crystallinity deposited as thin films on glass plates. Up to now, this aspect has not been carefully investigated in the context of bio-ceramics. In this study, we present the osteoblasts activity on synthesized HAP-Sr for different amounts of strontium substitution for calcium within the hydroxyapatite (Ca10(PO4)6(OH)2, HAP) lattice, namely HAP-5%Sr, HAP-10%Sr, HAP-15%Sr and HAP-59.2%Sr (Sr-HAP, of formula Sr10(PO4)6(OH)2), in comparison with stoichiometric pure HAP, chosen as control. Each bio-ceramic was deposited as thin multilayers self-assembled substrate (scaffold) and chemically bonded to the surface of glass plates. These coatings revealed by AFM and SEM imaging a granular texture formed from bio-ceramic nanoparticles. They possessed a high degree of crystallinity, i.e. 68% to 86%, depending on the Sr amount within the HAP lattice, as judged by XRD. Osteoblasts were cultured up to 21days and displayed enhanced adhesion and proliferation particularly evidenced on relatively high strontium contents (especially 5 and 10 weight %, determined by SEM-EDX), where the alkaline phosphatase activity and type I collagen were strongly evidenced. These bio-ceramics showed a high in vitro biocompatibility stimulating the activity of osteoblasts in the process of bone formation. These nano biomaterials can have applications in orthopedic and dental surgery improving the osteointegration as coatings of bone implants as well as for bone repair and regeneration.

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Section: Results and Discussion Hap And Hap-sr Substrates (Scaffolds)mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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In vitro Response of Human Osteoblasts Cultured on Strontium Substituted Hydroxyapatites

Răpuntean¹,

Frangopol²,

Hodisan³

et al. 2019

Rev. Chim.

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“…It has been reported that typically 1%-2% of patients with total hip arthroplasties suffer deep infections [21]. Dental peri-implant disease and infection have become a main focus of oral implantology [22]. Strontium (Sr) and silver (Ag) ion are candidates for the promotion of new bone formation and prevention of infection since the former exerts a therapeutic effect on osteoporosis bone due to increased new bone formation and deceased bone resorption, while the later prevents infection because of its strong effect against a broad range of microorganisms [23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Tri-Functional Calcium-Deficient Calcium Titanate Coating on Titanium Metal by Chemical and Heat Treatment

Yamaguchi

Ito

et al. 2019

Coatings

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The main problem of orthopedic and dental titanium (Ti) implants has been poor bone-bonding to the metal. Various coatings to improve the bone-bonding, including the hydroxyapatite and titania, have been developed, and some of them have been to successfully applied clinical use. On the other hand, there are still challenges to provide antibacterial activity and promotion of bone growth on Ti. It was shown that a calcium-deficient calcium titanate coating on Ti and its alloys exhibits high bone-bonding owing to its apatite formation. In this study, Sr and Ag ions, known for their promotion of bone growth and antibacterial activity, were introduced into the calcium-deficient calcium titanate by a three-step aqueous solution treatment combined with heat. The treated metal formed apatite within 3 days in a simulated body fluid and exhibited antibacterial activity to Escherichia coli without showing any cytotoxicity in MC3T3-E1 preosteoblast cells. Furthermore, the metal slowly released 1.29 ppm of Sr ions. The Ti with calcium-deficient calcium titanate doped with Sr and Ag will be useful for orthopedic and dental implants, since it should bond to bone because of its apatite formation, promote bone growth due to Sr ion release, and prevent infection owing to its antibacterial activity.

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“…Calcium (Ca 2+ ) is an essential ion that is involved in many physiological processes. In bone, Ca 2+ has both a structural role, as one of the major constituents of the mineral phase, and a key signaling role influencing the formation and regeneration of bone tissue (O'Neill, Awale, Daneshmandi, Umerah, & KW-H, 2018). H 2 O 2 is a reactive oxygen species, that is, ubiquitously produced by cells in aerobic metabolism (Wittmann et al, 2012).…”

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confidence: 99%

Regenerative engineered vascularized bone mediated by calcium peroxide

Daneshmandi

Laurencin

2020

J Biomedical Materials Res

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One of the main challenges hindering the clinical translation of bone tissue engineering scaffolds is the lack of establishment of functional vasculature. Insufficient vascularization and poor oxygen supply limit cell survival within the constructs resulting in poor osseointegration with the host tissue and eventually leading to inadequate bone regeneration. Inspired by cues from developmental biology, we regenerative engineered a composite matrix by incorporating calcium peroxide (CaO2) into poly(lactide‐co‐glycolide) (PLGA) microsphere‐based matrices and sought to assess whether the delivery of the byproducts of CaO2 decomposition, namely O2, Ca2+, and H2O2 could enhance the regeneration of vascularized bone tissue. The composite microspheres were successfully fabricated via the oil‐in‐water emulsion method. The presence and encapsulation of CaO2 was confirmed using scanning electron microscopy, energy dispersive x‐ray spectroscopy, thermogravimetric analysis, and X‐ray powder diffraction. The microspheres were further heat sintered into three‐dimensional porous scaffolds and characterized for their degradation and release of byproducts. The in vitro cytocompatibility of the matrices and their ability to support osteogenic differentiation was confirmed using human adipose‐derived stem cells. Lastly, an in vivo study was performed in a mouse critical‐sized calvarial defect model to evaluate the capacity of these matrices in supporting vascularized bone regeneration. Results demonstrated that the presence of CaO2 increased cellularization and biological activity throughout the matrices. There was greater migration of host cells to the interior of the matrices and greater survival and persistence of donor cells after 8 weeks, which in synergy with the composite matrices led to enhanced vascularized bone regeneration.

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The roles of ions on bone regeneration

Cited by 295 publications

References 110 publications

In vitro Response of Human Osteoblasts Cultured on Strontium Substituted Hydroxyapatites

In vitro Response of Human Osteoblasts Cultured on Strontium Substituted Hydroxyapatites

Tri-Functional Calcium-Deficient Calcium Titanate Coating on Titanium Metal by Chemical and Heat Treatment

Regenerative engineered vascularized bone mediated by calcium peroxide

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