2018
DOI: 10.1016/j.drudis.2018.01.049
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The roles of ions on bone regeneration

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Cited by 295 publications
(193 citation statements)
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References 110 publications
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“…The synthesized pure stoichiometric HAP: Ca 10 (PO 4 ) 6 (OH) 2 and Sr substituted hydroxyapatites. HAP-Sr: SrHAP: Sr 10 (PO 4 ) 6 (OH) 2 ; HAP-5%Sr: Ca 9.41 Sr 0.59 (PO 4 ) 6 (OH) 2 ; HAP-10% Sr: Ca 8.79 Sr 1.21 (PO 4 ) 6 (OH) 2 ; and HAP-15% Sr: Ca 8.13 Sr 1.87 (PO 4 ) 6 (OH) 2 , correspond to the general formula Ca 10-x Sr x (PO 4 ) 6 (OH) 2 .…”
Section: Results and Discussion Hap And Hap-sr Substrates (Scaffolds)mentioning
confidence: 99%
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“…The synthesized pure stoichiometric HAP: Ca 10 (PO 4 ) 6 (OH) 2 and Sr substituted hydroxyapatites. HAP-Sr: SrHAP: Sr 10 (PO 4 ) 6 (OH) 2 ; HAP-5%Sr: Ca 9.41 Sr 0.59 (PO 4 ) 6 (OH) 2 ; HAP-10% Sr: Ca 8.79 Sr 1.21 (PO 4 ) 6 (OH) 2 ; and HAP-15% Sr: Ca 8.13 Sr 1.87 (PO 4 ) 6 (OH) 2 , correspond to the general formula Ca 10-x Sr x (PO 4 ) 6 (OH) 2 .…”
Section: Results and Discussion Hap And Hap-sr Substrates (Scaffolds)mentioning
confidence: 99%
“…The healing of fractures requires the use of biocompatible materials with specific physical and chemical properties as well as osteoconductive and bone regeneration capacity [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. In orthopedic surgery, a more difficult situation is associated with bone fragility, like osteoporosis [17,18], where a special attention is required concerning the selection of the graft material.…”
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confidence: 99%
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“…It has been reported that typically 1%-2% of patients with total hip arthroplasties suffer deep infections [21]. Dental peri-implant disease and infection have become a main focus of oral implantology [22]. Strontium (Sr) and silver (Ag) ion are candidates for the promotion of new bone formation and prevention of infection since the former exerts a therapeutic effect on osteoporosis bone due to increased new bone formation and deceased bone resorption, while the later prevents infection because of its strong effect against a broad range of microorganisms [23][24][25][26].…”
Section: Introductionmentioning
confidence: 99%
“…Calcium (Ca 2+ ) is an essential ion that is involved in many physiological processes. In bone, Ca 2+ has both a structural role, as one of the major constituents of the mineral phase, and a key signaling role influencing the formation and regeneration of bone tissue (O'Neill, Awale, Daneshmandi, Umerah, & KW-H, 2018). H 2 O 2 is a reactive oxygen species, that is, ubiquitously produced by cells in aerobic metabolism (Wittmann et al, 2012).…”
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confidence: 99%