The roles of IL-4, IL-5 and mast cells in the accumulation of eosinophils during allergic cutaneous late phase reaction in mice

Togawa, Michinori; Kiniwa, Mamoru; Nagai, Hiroichi

doi:10.1016/s0024-3205(01)01165-1

Cited by 21 publications

(23 citation statements)

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“…The major granule content of mast cell in the guinea pig esophagus is histamine suggesting that histamine released from mast cells may play an important role in this chemoattraction. Our results are consistent with previous findings in mast cell deficient mice (Ogawa et al, 2002;Kobayashi et al, 2000;Togawa et al, 2001;Blanchard et al, 2006). These studies compared the effect of OVA challenge on infiltration of airway and skin by eosinophils in mast cell deficient mice (WBB6F1/J-W/Wv) and congenic normal littermates (W/W+).…”

Section: Discussionsupporting

confidence: 94%

“…Two other studies (Roosje et al, 2004;Noli et al, 2003) report that the numbers of both eosinophils and mast cells in the tissues are significantly increased in models of allergic dermatitis. The results from several studies (Kung et al, 1995;Ogawa et al, 2002;Kobayashi et al, 2000;Togawa et al, 2001) on mast cell deficient mice (W/Wv) reveal that eosinophil recruitment into the inflammation sites after antigen challenges in sensitized animals is not increased in contrast to their congenic littermates. Recent study in patients with eosinophilic esophagitis reported an increase in the number of esophageal mast cells (Blanchard et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Antigen inhalation induces mast cells and eosinophils infiltration in the guinea pig esophageal epithelium involving histamine-mediated pathway

Stahl

et al. 2008

Life Sciences

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Antigen inhalation induces mast cells and eosinophils infiltration in the guinea pig esophageal epithelium involving histamine-mediated pathway

Stahl

et al. 2008

Life Sciences

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“…IgE has been shown to mediate immediate-type hypersensitivity via activation of mast cells, which release a series of chemical mediators including histamine and prostaglandins. Recent studies with murine models of skin inflammation have demonstrated that exogenous introduction of IgE or its gene induces immediate-type responses (ITRs) within a couple of hours, late-phase responses (LPRs) at 24 h, and very-late-phase responses (vLPRs) (third-phase response) several days after challenge (15)(16)(17)(18). Histopathological examination of vLPRs indicates epidermal hyperplasia and marked increases in lymphocyte and eosinophil cell numbers.…”

Section: Prostaglandin D 2 Plays An Essential Role In Chronic Allergicmentioning

confidence: 99%

“…Mouse responses of IgE-mediated cutaneous inflammation have been shown to consist of at least three phases, ITR, LPR and vLPR, together with marked infiltration by eosinophils and lymphocytes (15)(16)(17)(18). To examine the involvement of CRTH2 in IgEmediated cutaneous responses in vivo, we assessed the ear-swelling responses of CRTH2-deficient mice.…”

Section: Ige-mediated Cutaneous Responses In Crth2-deficient Micementioning

confidence: 99%

Prostaglandin D2 Plays an Essential Role in Chronic Allergic Inflammation of the Skin via CRTH2 Receptor

Satoh

Moroi

Aritake³

et al. 2006

The Journal of Immunology

181

166

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PGD2 plays roles in allergic inflammation via specific receptors, the PGD receptor designated DP and CRTH2 (chemoattractant receptor homologous molecule expressed on Th2 cells). We generated mutant mice carrying a targeted disruption of the CRTH2 gene to investigate the functional roles of CRTH2 in cutaneous inflammatory responses. CRTH2-deficent mice were fertile and grew normally. Ear-swelling responses induced by hapten-specific IgE were less pronounced in mutant mice, giving 35–55% of the responses of normal mice. Similar results were seen in mice treated with a hemopoietic PGD synthase inhibitor, HQL-79, or a CRTH2 antagonist, ramatroban. The reduction in cutaneous responses was associated with decreased infiltration of lymphocytes, eosinophils, and basophils and decreased production of macrophage-derived chemokine and RANTES at inflammatory sites. In models of chronic contact hypersensitivity induced by repeated hapten application, CRTH2 deficiency resulted in a reduction by approximately half of skin responses and low levels (63% of control) of serum IgE production, although in vivo migration of Langerhans cells and dendritic cells to regional lymph nodes was not impaired in CRTH2-deficient mice. In contrast, delayed-type hypersensitivity to SRBC and irritation dermatitis in mutant mice were the same as in wild-type mice. These findings indicate that the PGD2-CRTH2 system plays a significant role in chronic allergic skin inflammation. CRTH2 may represent a novel therapeutic target for treatment of human allergic disorders, including atopic dermatitis.

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“…These cytokines have been reported to be involved in eosinophil recruitment, suggesting that either CD4 T cells, mast cells, or both play a role in development of the antigen-induced LTR. The OVAinduced biphasic cutaneous reaction is well documented to show both the ITR and the LTR (33,34).…”

Section: Discussionmentioning

confidence: 99%

The Combined Effect of Topical CX-659S, a Novel Diaminouracil Derivative, With Topical Corticosteroid on the Three Types of Allergic Responses in Mice or Guinea Pigs

2003

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Abstract. CX-659S ((S)-6-amino-5-(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido)-3-methyl-1-phenyl-2,4(1H,3H)-pyrimidinedione), a newly discovered anti-inflammatory compound, exerts inhibitory effects against picryl chloride-, oxazolone-, and dinitrochlorobenzeneinduced acute contact hypersensitivity responses (CHRs) characterized by Th1-type reactions. Furthermore, this compound suppressed chronic CHRs characterized by Th2-type reactions, which is well known to mimic many, if not all, events occurring within the lesional skin of patients with atopic dermatitis (AD). The present study was conducted to determine the combined effect of topical CX-659S with topical corticosteroid on immediate type (ITR), late type (LTR), and delayed type hypersensitivity (DTHR) allergic reactions that are involved in AD. An ineffective dose of CX-659S (0.03 mg / ear) combined with betamethasone valerate (BV) significantly potentiated inhibitory activity of BV alone (0.1 m g / ear and 0.3 m g / ear) on both the ITR and the LTR in mice with the ovalbumin (OVA)-induced biphasic cutaneous reaction. Furthermore, the combined effect of CX-659S with BV was also observed on dinitrochlorobenzene (DNCB)-induced DTHR in guinea pigs. These results indicate that CX-659S has a combined effect with corticosteroids on every ITR, LTR, and DTHR. Proper treatment with corticosteroids for a safe and effective treatment of AD is needed. Thus, the combination therapy of topical CX-659S with topical corticosteroid would be one of the potential approaches for devising a proper treatment with corticosteroids.

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The roles of IL-4, IL-5 and mast cells in the accumulation of eosinophils during allergic cutaneous late phase reaction in mice

Cited by 21 publications

References 0 publications

Antigen inhalation induces mast cells and eosinophils infiltration in the guinea pig esophageal epithelium involving histamine-mediated pathway

Antigen inhalation induces mast cells and eosinophils infiltration in the guinea pig esophageal epithelium involving histamine-mediated pathway

Prostaglandin D2 Plays an Essential Role in Chronic Allergic Inflammation of the Skin via CRTH2 Receptor

The Combined Effect of Topical CX-659S, a Novel Diaminouracil Derivative, With Topical Corticosteroid on the Three Types of Allergic Responses in Mice or Guinea Pigs

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