The Roles of IL-10 Gene Polymorphisms in Diabetes Mellitus and Their Associated Complications: A Meta-Analysis

Abstract

The roles of gene polymorphisms in diabetes mellitus (DM) have been intensively analyzed earlier, but the results of these studies were conflicting. Hence, we performed this study to better assess the relationship between genetic variations and DM. Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess correlations between polymorphisms and DM. A total of 32 studies were finally included in our analyses. Significant associations with the risk of DM were detected for the rs1800871, rs1800872, and rs1800896 polymorphisms. As for complications in DM, significant association with the risk of diabetic nephropathy (DN) was detected for the rs1800871 polymorphism. In addition, we also found that the rs1800896 polymorphism was significantly associated with the risk of diabetic retinopathy (DR). Further stratified analyses on the basis of type of disease demonstrated that the positive results were predominantly driven by the T2DM subgroup. When we stratified data based on ethnicity of participants, we found that the rs1800871 polymorphism was significantly correlated with DM in Caucasians, the rs1800872 polymorphism was significantly correlated with DM in Asians, and the rs1800896 polymorphism was significantly correlated with DM in both Caucasians and Asians. Our findings indicate that rs1800871, rs1800872, and rs1800896 polymorphisms may serve as genetic biomarkers of DM. Moreover, the rs1800871 and rs1800896 polymorphisms may also contribute to the development of complications in DM.

Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy

“…However, only a few genetic reports support possible pleiotropy between DN and DR 16 17 34 35. Hosseini et al 36 tested previous suggestive signals for DN for association with severe DR, but none of the loci showed a significant association after multiple testing.…”

“…Therefore, genetic loci with pleiotropic effects, whereby one genetic locus can affect more than one phenotype, may underlie the association between DR and DKD phenotypes 15. However, to date only a few genetic polymorphisms have been reported to be associated with these two complications, including interleukin (IL)-1016 and SLC2A1 17…”

Whether the risk of gestational diabetes mellitus is affected by TNF-α, IL-6, IL-10 or ADIPOQ polymorphisms: a meta-analysis

“…So if detailed genotypic distribution data could not be obtained from a certain study, we would not include it for pooled analyses even if it is a GWAS. Seventh, it is worth noting that previous meta-analyses found that IL-10 − 819C/T (rs1800871), IL-10 − 592C/A (rs1800872), IL-10 − 1082A/G (rs1800896), TNF-α − 308 G/A (rs1800629) and ADIPOQ + 45T/G (rs2241766) were significantly associated with the risk of T2DM, whereas IL6 − 174 G/C (rs1800795) was significantly associated with the risk of nephrology in T2DM patients [ 19 – 22 ]. Considering that GDM patients have a significantly higher risk of developing T2DM and its associated complications, it is believed that GDM and T2DM may share similar genetic traits.…”

The pathogenic role of IL10 gene polymorhisms in type 1 diabetes mellitus

“…A -rs3024505 [8,9]. Также имеются данные о снижении количества и функциональной активности IL10 у больных с аутоимунными заболеваниями, являющихся носителями аллеля Т полиморфного маркера rs1800872, расположенного в промоторной области гена [10].…”