The Roles of Genetic Factors in Uveitis and Their Clinical Significance

Yang, Mingming; Lai, Timothy Y. Y.; Luk, Franklin T.; Pang, Chi‐Pui

doi:10.1097/iae.0b013e31829f7415

Cited by 23 publications

(16 citation statements)

References 107 publications

(89 reference statements)

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“…15 Current anti-VEGF therapies delivered intravitreally include ranibizumab and aflibercept, as well as off-label bevacizumab. A main functional difference between aflibercept and other anti-VEGF agents is blockage of VEGF-B, PGF1, and PGF-2 in addition to VEGF-A isoforms.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Anti-Vascular Endothelial Growth Factor Drugs on Retinal Pigment Epithelial Cell Culture

Sahiner

Bahar

Öner

et al. 2018

tjo

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Objectives:To assess the effects of anti-vascular endothelial growth factor (VEGF) drugs on retinal pigment epithelium cell culture.Materials and Methods:Aflibercept (0.5 mg/mL), bevacizumab (0.3125 mg/mL), and ranibizumab (0.125 mg/mL) were applied to retinal pigment epithelium cell cultures isolated from the enucleated eyes of New Zealand white rabbits. Viability, apoptosis, proliferation, and senescence of the cells were evaluated in control and drug-treated cultures at the end of 72 hours.Results:Cells treated with aflibercept showed increased viability and decreased apoptosis compared to the control culture and both the bevacizumab- and ranibizumab-treated groups (p<0.05). Statistically increased apoptosis and decreased viability were found in the bevacizumab and ranibizumab-treated groups compared with the control group (p<0.05). There were no statistically significant differences in cell proliferation and senescence between the groups (p>0.05).Conclusion:Anti-VEGF drugs did not affect senescence or proliferation of retinal pigment epithelium cells. Aflibercept was found to decrease apoptosis and increase cell viability, while ranibizumab and bevacizumab increased apoptosis and reduced cell viability in retinal pigment epithelium culture.

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Section: Discussionmentioning

confidence: 99%

The Effects of Anti-Vascular Endothelial Growth Factor Drugs on Retinal Pigment Epithelial Cell Culture

Sahiner

Bahar

Öner

et al. 2018

tjo

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“…Beyond the MHC, several genes encoding for cytokines, chemokines, or immunoregulatory proteins have been assessed with respect to their participations in the pathogenesis of BD, but results obtained were inconsistent [51, 133, 134]. Two recent GWAS reports from Turkey and Japan and their additional meta-analyses which included cohorts from Europe, Middle East, and Korea revealed consistent and significant associations between the IL-10 and IL-23R/IL-12RB2 genes and BD [109, 114].…”

Section: Genetic Mechanisms Of Susceptibility To Behçet's Uveitismentioning

confidence: 99%

Immunopathogenesis of Ocular Behçet’s Disease

Park

Kim

2014

Journal of Immunology Research

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Behçet's disease (BD) is a chronic recurrent systemic inflammatory disorder of unknown etiology characterized by oral and genital ulcerations, skin lesions, and uveitis. The ocular involvement of BD, or Behçet's uveitis (BU), is characterized by panuveitis or posterior uveitis with occlusive retinal vasculitis and tends to be more recurrent and sight threatening than other endogenous autoimmune uveitides, despite aggressive immunosuppression. Although pathogenesis of BD is unclear, researches have revealed that immunological aberrations may be the cornerstone of BD development. General hypothesis of BD pathogenesis is that inflammatory response is initiated by infectious agents or autoantigens in patients with predisposing genetic factors and perpetuated by both innate and acquired immunity. In addition, a network of immune mediators plays a substantial role in the inflammatory cascade. Recently, we found that the immunopathogenesis of BU is distinct from other autoimmune uveitides regarding intraocular effector cell profiles, maturation markers of dendritic cells, and the cytokine/chemokine environment. In addition, accumulating evidence indicates the involvement of Th17 cells in BD and BU. Recent studies on genetics and biologics therapies in refractory BU also support the immunological association with the pathogenesis of BU. In this review, we provide an overview of novel findings regarding the immunopathogenesis of BU.

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“…3 The exact pathogenesis of AAU is still unclear, but accumulating evidence has demonstrated that the disease is immune mediated and influenced by various endogenous factors. 4,5 For instance, studies have shown that singlenucleotide polymorphisms (SNPs) in TNF and their associated receptors are associated with AAU. 6 The levels of CCL2, CCL5, and their receptors have also been found to be significantly correlated with the severity of inflammation in AAU patients.…”

Section: Introductionmentioning

confidence: 99%

Association of CD59 and CFH polymorphisms with acute anterior uveitis in Chinese population

Wang

Huang

Zheng

et al. 2016

Eye

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PurposeCD59 complement regulator and complement factor H (CFH) have important roles in complement activation pathways, which are known to affect the development of uveitis. The present study was performed to investigate whether an association exists between CD59 and CFH genetic polymorphisms and acute anterior uveitis (AAU).MethodsA total of 600 individuals (300 patients diagnosed with AAU and 300 healthy controls) were recruited for this case-control study. Five single-nucleotide polymorphisms (SNPs) in CD59 (rs831626, rs12272807, rs831625, rs11585, and rs12576440) and CFH-rs1065489 were genotyped using Sequenom MassARRAY technology. Allele and genotype frequencies were statistically compared between patients and controls using χ test. Analyses were stratified for gender, human leukocyte antigen (HLA)-B27, and ankylosing spondylitis (AS) status.ResultsNo significant association was found between any of the six polymorphisms and AAU. In HLA-B27-negative AAU patients, the frequencies of the G allele and GG homozygosity were lower in CD59-rs831626 when compared with controls (P=0.032). There were also significant decreases in the frequencies of T allele and TT homozygosity in CFH-rs1065489 in AAU patients with AS compared with controls (P=0.002). Furthermore, the frequencies of the T allele and TT homozygosity in CFH-rs1065489 were lower in the AAU male patients with AS compared with controls (P=0.015).ConclusionOur results revealed that SNPs CD59-rs831626 and CFH-rs1065489 were associated with the susceptibility of AAU. The influence on AAU could be gender specific and dependent on the HLA-B27 and AS status. No positive results were found in the overall group.

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The Roles of Genetic Factors in Uveitis and Their Clinical Significance

Cited by 23 publications

References 107 publications

The Effects of Anti-Vascular Endothelial Growth Factor Drugs on Retinal Pigment Epithelial Cell Culture

The Effects of Anti-Vascular Endothelial Growth Factor Drugs on Retinal Pigment Epithelial Cell Culture

Immunopathogenesis of Ocular Behçet’s Disease

Association of CD59 and CFH polymorphisms with acute anterior uveitis in Chinese population

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