The roles of DDR2 and substrate stiffness on cancer cell transcriptome and proliferation
Theadora Vessella,
Steven Xiang,
Cong Xiao
et al.
Abstract:The interactions between cancer cells and the ECM regulate carcinogenesis. The collagen receptor kinase DDR2 is dysregulated in certain cancer cells, but its precise role in these malignancies remains unclear. In this study, we perform RNA-seq to determine how DDR2 and the biomechanical environment regulate cancer cell behaviors. We show that DDR2 knockdown in SH-SY5Y neuroblastoma cells inhibits proliferation and promotes senescence by regulating relevant genes. Increasing substrate stiffness reduces prolifer… Show more
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