The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis

Li, Hao; Tian, Lijun; Li, Jianhua; Li, Yongjin; Du, Lilong; Huo, Zhenxin; Xu, Bei

doi:10.1155/2022/9550499

Cited by 16 publications

(25 citation statements)

References 106 publications

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“…Однако в некоторых кольцевых РНК третья позиция более консервативна, чем в экзонах (которые не входят в состав кольцевой РНК), что позволяет предположить, что эти высокостабильные кольцевые РНК обладают значительными некодирующими функциями. Кольцевые РНК могут действовать как посттранскрипционные регуляторы, конкурируя за связывание с микроРНК и РСБ с другими видами РНК [197,198]. Если функциональная классификация в целом выполняется в соответствии с мишенью кольцевой РНК, то их, как правило, можно разделить на две категории: регулирующие сайт-мишень и регулирующие его ген.…”

Section: научные обзорыunclassified

Circular RNAs in eukaryotic cells: origin, characteristics, mechanisms of molecular functioning in human malignant diseases

Vashchenko

Chuklovin

Shabanov

2023

Rev Clin Pharm Drug Ther

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Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding endogenous RNAs (ncRNAs) found in the eukaryotic transcriptome, originally believed to be aberrant RNA splicing by-products with limited functionality. However, recent advances in highthroughput genomic technology have allowed circRNAs to be characterized in detail and revealed their important functions in controlling various biological and molecular processes, the most essential being gene regulation. Due to structural stability, high expression, availability of microRNA (miRNA) binding sites and tissue-specific expression, circRNAs have become hot topic of research in RNA 2 biology. Unlike linear RNAs, circRNAs are produced differentially by backsplicing exons or lariat introns from a pre-messenger RNA (mRNA) forming covalently closed loop-like molecules missing 3' poly-(A) tail or 5' cap structures, thus rendering them resistant to exonuclease-mediated degradation. Previous studies have revealed multiple roles of circRNAs as sponges for miRNA and RNA-binding proteins (RBP), as well as regulators of transcription, translation, and splicing events. Recent advances in the field suggest that the circRNAs are involved in many human disorders, including cancer and neurodegenerative disorders such as Alzheimers and Parkinsons disease, due to their aberrant expression in different pathological conditions. The circRNAs are stable in cells, owing to their circular structure. Participation of circRNAs in programmed cellular destruction by autophagy is discussed in details. The autophagy is a catabolic process which promotes decomposition and recycling of harmful or redundant biological macromolecules and initiates destruction of ageing cells. Processes how circRNAs influence a course of a disease, including an autophagy are in detail discussed, specifying that it joins at the beginning and upon development of various illnesses, and it can influence drug resistance (for example, antitumor efficiency of Cisplatin). The functional versatility exhibited by circRNAs enables them to serve as potential diagnostic or predictive biomarkers for various diseases. This review discusses the properties, characterization, profiling, and the diverse molecular actions of circRNAs and their usage as potential therapeutic targets in different human malignancies.

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Section: научные обзорыunclassified

Circular RNAs in eukaryotic cells: origin, characteristics, mechanisms of molecular functioning in human malignant diseases

Vashchenko

Chuklovin

Shabanov

2023

Rev Clin Pharm Drug Ther

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“…Degenerated IDs exhibit higher rates of apoptosis, but the underlying mechanisms remain unclear ( 55 ). Importantly, evidence indicates that ncRNAs are involved in abnormal apoptosis of NP cells during IDD ( 56 ). It is reported that numerous ncRNAs can simultaneously affect the process of apoptosis and autophagy during development of IDD ( 57 , 58 ).…”

Section: Ncrnas In Autophagy and Apoptosismentioning

confidence: 99%

Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review)

et al. 2022

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Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, which is one of the primary factors that lead to disability and pose a serious economic burden.The key pathological processes involved are extracellular matrix degradation, autophagy, apoptosis, and inflammation of nucleus pulposus cells. Non-coding RNAs (ncRNAs), including microRNAs, long ncRNAs and circular RNAs, are key regulators of the aforementioned processes. ncRNAs are differentially expressed in tissues of the intervertebral disc between healthy individuals and patients and participate in the pathological progression of IDD via a complex pattern of gene regulation. However, the regulatory mechanisms of ncRNAs in IDD remain unclear. The present review summarizes the latest insights into the regulatory role of ncRNAs in IDD and sheds light on potentially novel therapeutic strategies for IDD that may be implemented in the future. Contents1. Introduction 2. ncRNAs in ECM degradation 3. ncRNAs in autophagy and apoptosis 4. ncRNAs in inflammation 5. Conclusion

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“…ncRNA includes short hairpin RNA (shRNA), small interfering RNA (siRNA), antisense RNA, microRNA (miRNA), long non-coding RNA (lncRNA), circular RNA (circRNA), and extracellular RNA [ 260 , 261 , 262 ]. Although evidence suggests that miRNA, lncRNA, and circRNA contribute to the progression of IVDD by affecting the processes of apoptosis, cell proliferation, ECM degradation, and inflammation [ 263 , 264 , 265 , 266 ], the role of ncRNA in autophagy is unclear. Figure 4 depicts autophagy-targeting ncRNAs that can be exploited to treat IVDD.…”

Section: Autophagy As a Potential Therapeutic Target For Ivddmentioning

confidence: 99%

“…circRNA regulates gene transcription and translation as well as inflammatory cytokine release, ECM metabolism, and cell proliferation and death [ 266 ], suggesting that it could be therapeutically targeted in IVDD. However, our understanding of the mechanism by which circRNA impacts IVDD is still limited.…”

Section: Autophagy As a Potential Therapeutic Target For Ivddmentioning

confidence: 99%

“…However, our understanding of the mechanism by which circRNA impacts IVDD is still limited. circRNAs were recently reported to influence pathogenic processes of IVDD including inflammation, ECM metabolism, NP cell proliferation, autophagy, and apoptosis by acting as ceRNAs [ 266 , 299 , 300 , 301 ]. Thus, these newly discovered ceRNA interaction sites could be important targets for IVDD treatment [ 167 , 291 ].…”

Section: Autophagy As a Potential Therapeutic Target For Ivddmentioning

confidence: 99%

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Targeting Autophagy for Developing New Therapeutic Strategy in Intervertebral Disc Degeneration

et al. 2022

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Intervertebral disc degeneration (IVDD) is a prevalent cause of low back pain. IVDD is characterized by abnormal expression of extracellular matrix components such as collagen and aggrecan. In addition, it results in dysfunctional growth, senescence, and death of intervertebral cells. The biological pathways involved in the development and progression of IVDD are not fully understood. Therefore, a better understanding of the molecular mechanisms underlying IVDD could aid in the development of strategies for prevention and treatment. Autophagy is a cellular process that removes damaged proteins and dysfunctional organelles, and its dysfunction is linked to a variety of diseases, including IVDD and osteoarthritis. In this review, we describe recent research findings on the role of autophagy in IVDD pathogenesis and highlight autophagy-targeting molecules which can be exploited to treat IVDD. Many studies exhibit that autophagy protects against and postpones disc degeneration. Further research is needed to determine whether autophagy is required for cell integrity in intervertebral discs and to establish autophagy as a viable therapeutic target for IVDD.

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The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis

Cited by 16 publications

References 106 publications

Circular RNAs in eukaryotic cells: origin, characteristics, mechanisms of molecular functioning in human malignant diseases

Circular RNAs in eukaryotic cells: origin, characteristics, mechanisms of molecular functioning in human malignant diseases

Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review)

Targeting Autophagy for Developing New Therapeutic Strategy in Intervertebral Disc Degeneration

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