The role played by oral antioxidant therapies in preventing and treating preeclampsia: An updated meta-analysis

Alves, Palloma R.M.M.; Fragoso, Marilene Brandão Tenório; Tenório, Micaely C.S.; Bueno, Nassib Bezerra; Goulart, Marília Oliveira Fonseca; Oliveira, Alane Cabral Menezes de

doi:10.1016/j.numecd.2023.02.003

Cited by 2 publications

(2 citation statements)

References 52 publications

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“…Another large meta-analysis has recently shown that antioxidant therapy might reduce the risk of IUGR when administered after diagnosis of preeclampsia [ 112 ]. However, the studies included in this analysis were very heterogeneous using different antioxidant compounds.…”

Section: Strategies To Prevent or Mitigate Iugrmentioning

confidence: 99%

Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae

Nüsken,

Appel,

Saschin

et al. 2024

Cells

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Intrauterine growth restriction (IUGR) and being small for gestational age (SGA) are two distinct conditions with different implications for short- and long-term child development. SGA is present if the estimated fetal or birth weight is below the tenth percentile. IUGR can be identified by additional abnormalities (pathological Doppler sonography, oligohydramnion, lack of growth in the interval, estimated weight below the third percentile) and can also be present in fetuses and neonates with weights above the tenth percentile. There is a need to differentiate between IUGR and SGA whenever possible, as IUGR in particular is associated with greater perinatal morbidity, prematurity and mortality, as well as an increased risk for diseases in later life. Recognizing fetuses and newborns being “at risk” in order to monitor them accordingly and deliver them in good time, as well as to provide adequate follow up care to ameliorate adverse sequelae is still challenging. This review article discusses approaches to differentiate IUGR from SGA and further increase diagnostic accuracy. Since adverse prenatal influences increase but individually optimized further child development decreases the risk of later diseases, we also discuss the need for interdisciplinary follow-up strategies during childhood. Moreover, we present current concepts of pathophysiology, with a focus on oxidative stress and consecutive inflammatory and metabolic changes as key molecular mechanisms of adverse sequelae, and look at future scientific opportunities and challenges. Most importantly, awareness needs to be raised that pre- and postnatal care of IUGR neonates should be regarded as a continuum.

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Section: Strategies To Prevent or Mitigate Iugrmentioning

confidence: 99%

Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae

Nüsken,

Appel,

Saschin

et al. 2024

Cells

View full text Add to dashboard Cite

show abstract

“…To date, there is no recommendation for the use of sildenafil in the societies' guidelines. Another large meta-analysis has recently shown that antioxidant therapy might reduce the risk of IUGR when administered after diagnosis of preeclampsia [95]. However, the included studies were very heterogeneous using different antioxidant compounds.…”

Section: The Research View-future Perspectivesmentioning

confidence: 99%

Intrauterine Growth Restriction: Improving Diagnostic Accuracy and the Role of Oxidative Stress in Neonatal and Long-Term Sequels

Nüsken,

Appel,

Saschin

et al. 2023

Preprint

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Intrauterine growth restriction (IUGR) and being born small for gestational age (SGA) are two distinct conditions with different implications for child development. IUGR is associated with greater perinatal morbidity and mortality and can be identified by additional abnormalities (pathological Doppler sonography, oligohydramnios, lack of growth in the interval, estimated weight <3rd percentile). IUGR may also be present in neonates with birth weights above the 10th percentile. Recognizing fetuses being “at risk” of a higher perinatal mortality and morbidity rate in order to monitor them accordingly and deliver them in good time is still challenging. This review article summarizes approaches to increase the diagnostic accuracy of IUGR and presents current concepts of pathophysiology with a focus on oxidative stress and consecutive inflammatory and metabolic changes. Since prenatal influences affect the risk of later diseases, we also discuss the need for interdisciplinary follow-up strategies during childhood and look at future scientific challenges. It should be emphasized that prenatal and postnatal care of IUGR neonates should be regarded as a continuum.

show abstract

The role played by oral antioxidant therapies in preventing and treating preeclampsia: An updated meta-analysis

Cited by 2 publications

References 52 publications

Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae

Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae

Intrauterine Growth Restriction: Improving Diagnostic Accuracy and the Role of Oxidative Stress in Neonatal and Long-Term Sequels

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