The role of γδ T17 cells in cardiovascular disease

Abstract

Due to the ability of γδ T cells to bridge adaptive and innate immunity, γδ T cells can respond to a variety of molecular cues and acquire the ability to induce a variety of cytokines such as IL-17 family, IFN-γ, IL-4, and IL-10. IL-17 + γδ T cells (γδ T17 cells) populations have recently received considerable interest as they are the major early source of IL-17A in many immune response models. However, the exact mechanism of γδ T17 cells is still poorly understood, especially in the context of cardiovascular disease (CVD). CVD is the leading cause of death in the world, and it tends to be younger.Here, we offer a review of the cardiovascular inflammatory and immune functions of γδ T17 cells in order to understand their role in CVD, which may be the key to developing new clinical applications.

Expansion and Polarization of Human γδT17 Cells in vitro from Peripheral Blood Mononuclear Cells

“…Surface markers such as CD27 and CCR6 can be used to define these two subsets ( Haas et al, 2009 ; Ribot et al, 2009 ). In humans, γδ T cells can be distinguished by the δ chain, including Vδ1, Vδ2, Vδ3, and Vδ5 ( Ling et al, 2022 ). While previous studies have reported methods for in vitro expansion of human γδ T cells ( Ness-Schwickerath et al, 2010 ; Caccamo et al, 2011 ; Hur et al, 2023 ), the majority of peripheral blood γδ T cells in humans are Vδ2 + subsets that mainly produce IFN-γ.…”