The role of Zinc L-Carnosine in the prevention and treatment of gastrointestinal mucosal disease in humans: a review.

Dietary zinc supplements: beneficial health effects and application in food, medicine and animals

“…168,169 In human studies, zinc L-creatine has been shown to promote the repair of mucosal damage and has been widely used in the treatment of peptic ulcers, radiotherapy-induced oral mucositis and esophagitis. 170 Polaprezinc induces upregulation of osteogenic-related genes and enhances the osteogenic potential of human bone marrow-derived mesenchymal stem cells and the osteoclast differentiation potential of mouse bone marrowderived monocytes. 171 In addition to the cases discussed above, zinc has been used to treat several other diseases; for example, zinc supplementation can prevent otitis media, 172 acts as an anti-allergic and antiinflammatory agent, 173 as an adjunctive therapy to relieve inflammation and genital ulcers in patients with leukodystrophy, 174 treatment of skin diseases, and so forth.…”

“…In human studies, zinc l ‐creatine has been shown to promote the repair of mucosal damage and has been widely used in the treatment of peptic ulcers, radiotherapy‐induced oral mucositis and esophagitis 170 . Polaprezinc induces upregulation of osteogenic‐related genes and enhances the osteogenic potential of human bone marrow‐derived mesenchymal stem cells and the osteoclast differentiation potential of mouse bone marrow‐derived monocytes 171 …”

Oral Mucositis Management in Children under Cancer Treatment: A Systematic Review

“…Polaprezinc or zinc L-carnosine suspension in sodium alginate were effective in decreasing the incidence of oral mucositis [33]. Although polaprezinc is safe [66], several children refused the intervention with this compound because of an unpleasant flavor and texture [33]. Polaprezinc's taste needs to be improved, as its effectiveness in reducing oral mucositis in children is promising due to its wound-healing and antioxidant properties [33,67].…”