The Role of Zinc in Cardiovascular Disease

Abstract

Zinc is an essential trace element due to its role as a key part of human enzymatic activity. As a cofactor in metalloenzymes and metalloproteins, zinc participates in diverse biological functions, including gene transcription, translation, and replication, phagocytosis, and immunoglobulin and cytokine production. In this review, we will focus on the role of zinc in the cardiovascular system, including heart failure, vascular calcification, and myocardial infarction. We will further highlight the role of zinc in cardiovascular pathology in individuals with chronic kidney disease, and type II diabetes mellitus, groups uniquely at risk for cardiovascular morbidity and mortality.

Zn2SiO4 Bioceramic Attenuates Cardiac Remodeling after Myocardial Infarction

“…Furthermore, Zn ions have been associated with cardiovascular diseases such as congestive heart failure, myocardial infarction, arrhythmias, diabetic cardiomyopathy, atherosclerosis, and atherothrombosis. [ 24 ] In the present investigation, we demonstrated the critical function of Zn in cardiac remodeling following myocardial infarction, primarily by mitigating ROS generation. Concurrently, the synergistic influence of Zn 2+ and SiO 3 2− ions on myocardial regeneration was thoroughly examined.…”

Resveratrol Inhibits Zinc Deficiency-Induced Mitophagy and Exerts Cardioprotective Effects

“…Zinc is essential for maintaining normal cell structure and physiology, enzyme activation, gene transcription, translation, replication, phagocytosis and the production of immunoglobulins and cytokines [13]. Zinc de ciency leads to a variety of physiological disorders such as apoptosis, organ destruction, DNA damage and oxidative damage, which lead to a variety of chronic diseases such as heart disease, cancer and neurological pathogenesis [34].…”

“…Zinc is an essential trace element for all organisms, involving in many biochemical processes such as gene transcription, translation and DNA replication, autophagy, and immunoglobulin and cytokine production [13]. Zinc is a key component of human enzymatic activity, a metalloenzymes and metalloproteins cofactor which involved in Zinc/zinc homeostasis-related molecules (ZIP, ZnT and MT) important for cardiovascular disease (CVD).…”

Alterations of Serum Magnesium Concentration in Animal Models of Seizures and Epilepsy—The Effects of Treatment with a GPR39 Agonist and Knockout of the Gpr39 Gene

“…Summarizing, our previous [11] and current data show that the GPR39 receptor participates in mediating the serum concentrations of zinc and magnesium. The direct link between these findings and other characteristics of Gpr39-KO mice remains to be established, but it is plausible, given the role of zinc and magnesium in disease areas [13][14][15][16][17][18][19] in which GPR39 is increasingly investigated (e.g., neurovascular diseases, cardiovascular diseases, bone diseases, CNS diseases such as depression, epilepsy, etc. [6][7][8][9][10][11][12]).…”

“…GPR39 is being investigated in relation to cardiovascular diseases [6], neurovascular diseases [7], diseases of the central nervous system (CNS) such as depression [8,9] or epilepsy [10,11], bone diseases [12], etc. Both elements-zinc and magnesium-play significant roles in the aforementioned conditions, more specifically in cardiovascular diseases [13,14], depression [15], epilepsy [16], or diseases of bones [17][18][19]. There is an overlap between the actions of these elements at the level of biochemistry/pharmacology.…”