The role of zinc in reproduction

Favier, Alain

doi:10.1007/bf02784623

Cited by 153 publications

(93 citation statements)

References 105 publications

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“…In contrast to the present study, previous trials which reported an increase of testosterone levels after zinc supplementation were conducted with zinc-deficient subjects: in pathological conditions, in which the zinc status is often poor, such as uraemia/haemodialysis (Antoniou et al, 1977;Mahajan et al, 1982), growth retardation (GhavamiMaibodi et al, 1983), sickle-cell anaemia (Prasad et al, 1981) or infertility (Netter et al, 1981;Favier, 1992), it was shown that administration of the trace element caused a reversal of previously lowered testosterone concentrations. Kilic et al (2006) reported that supplementation of zinc reversed reduced serum testosterone levels caused by exhaustion exercise.…”

Section: Discussioncontrasting

confidence: 94%

“…Except for this trial, supplementation of zinc has only been reported to increase testosterone in pathological conditions linked to a low zinc status (Favier, 1992) and in elderly men (Haboubi et al, 1988;Prasad et al, 1996). Therefore, the aim of the present study was to reinvestigate the claimed effect of the administration of ZMA on serum testosterone levels in young, physically active, healthy men in an independent placebo-controlled, double-blind trial.…”

Section: Introductionmentioning

confidence: 90%

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Serum testosterone and urinary excretion of steroid hormone metabolites after administration of a high-dose zinc supplement

et al. 2007

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Objectives: To investigate whether the administration of the zinc-containing nutritional supplement ZMA causes an increase of serum testosterone levels, which is an often claimed effect in advertising for such products; to monitor the urinary excretion of testosterone and selected steroid hormone metabolites to detect potential changes in the excretion patterns of ZMA users. Subjects: Fourteen healthy, regularly exercising men aged 22-33 years with a baseline zinc intake between 11.9 and 23.2 mg day À1 prior to the study. Results: Supplementation of ZMA significantly increased serum zinc (P ¼ 0.031) and urinary zinc excretion (P ¼ 0.035). Urinary pH (P ¼ 0.011) and urine flow (P ¼ 0.045) were also elevated in the subjects using ZMA. No significant changes in serum total and serum free testosterone were observed in response to ZMA use. Also, the urinary excretion pattern of testosterone metabolites was not significantly altered in ZMA users. Conclusions: The present data suggest that the use of ZMA has no significant effects regarding serum testosterone levels and the metabolism of testosterone in subjects who consume a zinc-sufficient diet.

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Section: Discussioncontrasting

confidence: 94%

Section: Introductionmentioning

confidence: 90%

Serum testosterone and urinary excretion of steroid hormone metabolites after administration of a high-dose zinc supplement

et al. 2007

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“…Zinc acts as a co-factor for enzymes promoting DNA transcription and protein synthesis [32], has a role in expression of steroid hormone receptors [33] and has anti-apoptotic [34] and anti-oxidant properties [35]. Studies have demonstrated that a zinc deficiency can lead to subfertility and abnormal reproductive outcomes [36], and to pregnancy complications [37,38]. However, previous studies have failed to confirm a role for zinc in human infertility or the response to fertility treatments.…”

Section: Discussionmentioning

confidence: 99%

Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation

Dickerson¹,

Sathyapalan

Knight

et al. 2011

J Assist Reprod Genet

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Purpose There is increasing concern that environmental chemicals have a direct effect on fertility. Heavy metals such as mercury have been shown to affect various organ systems in humans including nervous system and skin, however they could also act as endocrine disrupting chemicals adversely affecting fertility. Metals such as zinc and selenium are essential micronutrients with diverse functions that may be important for reproductive outcomes. We measured mercury, zinc and selenium levels in the hair, a reliable reflection of long term environmental exposure and dietary status, to correlate with the outcome of ovarian hyperstimulation for in vitro fertilisation (IVF) treatment. Methods We analysed the hair of 30 subfertile women for mercury, zinc and selenium using inductively coupled mass spectrometry. Each woman underwent one cycle of IVF treatment. Correlation between the levels of these trace metals and treatment outcomes was investigated.Results Thirty women were recruited with mean (±SD) age of 32.7(4.4) years and BMI of 25.4(5.0)kg/m 2 . Hair mercury concentration showed a negative correlation with oocyte yield (p<0.05,βcoefficient 0.38) and follicle number (p=0.03,β coefficient0.19) after ovarian stimulation. Zinc and selenium levels in hair correlated positively with oocyte yield after ovarian stimulation (p<0.05,β coefficient0.15) and (p=0.03,β coefficient0.21) respectively. Selenium levels in hair correlated significantly with follicle number following stimulation (p=0.04, βcoefficient0.22). There was no correlation between mercury, zinc and selenium in hair and their corresponding serum levels. Conclusion These data suggest that mercury had a deleterious effect whilst there was a positive effect for zinc and selenium in the ovarian response to gonadotrophin therapy for IVF. Hair analysis offers a novel method of investigating the impact of long-term exposure to endocrine disruptors and nutritional status on reproductive outcomes. Keywords IVF . Heavy metals . Endocrine disruptorsSubfertility affects approximately 1 in 6 couples in the developed world [1], a prevalence that is likely to increase as more women delay childbirth to a later age [2]; approximately 28% of couples investigated for subfertility have a diagnosis of 'unexplained subfertility' [3]. Current treatment largely consists of assisted reproductive techniques (ART) such as IVF or IVF-ICSI, often regardless of the underlying cause. The average success rate of 25-30% for ART in Europe remains unchanged over recent years [4], prompting the search for additional factors which may influence fertility treatments and optimise success, and the identification of adverse factors such as endocrine disrupting chemicals.Capsule Mercury concentration in hair had a deleterious effect where as zinc and selenium had a beneficial effect in ovarian response to gonadotrophin therapy for IVF.

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“…Zinc finger motifs are the most common recurring motif in transcription factors, with the 'finger' structure determined by the single zinc atom at its base that allows specific binding to DNA through the resulting conformation. Such motifs have been identified in various nuclear hormone receptors for steroids, thyroid hormones and vitamin D (Favier, 1992;Vallee and Falchuk, 1993;Meier, 1997).…”

Section: Zinc Participates In Gene Expression Controlmentioning

confidence: 99%

Nutrient-gene interactions: a single nutrient and hundreds of target genes

Daniel¹,

Dieck²

2004

Biological Chemistry

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Based on the effects of a selective experimental zinc deficiency in a rodent model we explore the use of transcriptome profiling for assessing nutrient-gene interactions in the liver at the molecular and cellular levels. Zinc deficiency caused pleiotropic alterations in mRNA/protein levels of hundreds of genes. In the context of observed metabolic alterations in hepatic metabolism, possible mechanisms are discussed for how a low zinc status may be sensed and transmitted into changes in various metabolic pathways. However, it also becomes obvious that analysis of such complex nutrient-gene interactions beyond the descriptional level is a real challenge for systems biology.

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The role of zinc in reproduction

Cited by 153 publications

References 105 publications

Serum testosterone and urinary excretion of steroid hormone metabolites after administration of a high-dose zinc supplement

Serum testosterone and urinary excretion of steroid hormone metabolites after administration of a high-dose zinc supplement

Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation

Nutrient-gene interactions: a single nutrient and hundreds of target genes

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