The role of zinc and its compounds in leukemia

Орлов, А. А.; Орлова, М. А.; Трофимова, Т. П.; Kalmykov, Stepan N.; Kuznetsov, Dmitry A.

doi:10.1007/s00775-018-1545-9

Cited by 26 publications

(19 citation statements)

References 149 publications

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“…Given that Zn 2+ has only one stable oxidation state in aqueous solution, its connection to redox is certainly not obvious, but this example illustrates the impact a single form of ionic Zn 2+ can have on many biological systems, even though some of these effects, such as redox, are indirect effects. Zn 2+ -related metabolism has been linked to the development of many disorders including diabetes [12], prostate cancer [13], benign prostatic hyperplasia (BPH) [14], Alzheimer's disease [15], multiple sclerosis [16], epilepsy [17], leukemia [18], other cancers [19], and more recently, COVID-19 [20,21].…”

Section: The Role Of Zinc In Human Physiologymentioning

confidence: 99%

Imaging Tissue Physiology In Vivo by Use of Metal Ion-Responsive MRI Contrast Agents

2020

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Paramagnetic metal ion complexes, mostly based on gadolinium (Gd3+), have been used for over 30 years as magnetic resonance imaging (MRI) contrast agents. Gd3+-based contrast agents have a strong influence on T1 relaxation times and are consequently the most commonly used agents in both the clinical and research environments. Zinc is an essential element involved with over 3000 different cellular proteins, and disturbances in tissue levels of zinc have been linked to a wide range of pathologies, including Alzheimer’s disease, prostate cancer, and diabetes mellitus. MR contrast agents that respond to the presence of Zn2+ in vivo offer the possibility of imaging changes in Zn2+ levels in real-time with the superior spatial resolution offered by MRI. Such responsive agents, often referred to as smart agents, are typically composed of a paramagnetic metal ion with a ligand encapsulating it and one or more chelating units that selectively bind with the analyte of interest. Translation of these agents into clinical radiology is the next goal. In this review, we discuss Gd3+-based MR contrast agents that respond to a change in local Zn2+ concentration.

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Section: The Role Of Zinc In Human Physiologymentioning

confidence: 99%

Imaging Tissue Physiology In Vivo by Use of Metal Ion-Responsive MRI Contrast Agents

2020

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“…Albeit, together both are extremely important for the normal body functioning in human body [90,91]. They are involved in triggering many important biochemical reactions for example-works as cofactors and coenzymes in metabolism [92,93,94,95]. However, micronutrients are getting large attention all over the world during the COVID-19 pandemic for its ability to alter the susceptibility to infection [96,97,98].…”

Section: Food Nutrients With Antiviral Activities Suggested For Covid-19mentioning

confidence: 99%

Prospects of nutritional interventions in the care of COVID-19 patients

Alam¹,

Bhuiyan²,

Emon³

et al. 2021

Heliyon

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The novel coronavirus disease 2019 (COVID-19) has unfolded an unprecedented worldwide public health emergency with disastrous economic consequences. Around 96 million coronavirus cases have already been identified with over half a million deaths. Despite numerous efforts by the government as well as international organizations, these numbers are still increasing with a surprising rate. Although urgent and absolutely necessary, a reliable therapeutic or vaccine is still elusive and this status quo may remain for an uncertain period of time. Taken that into account, boosting up adaptive immunity through nutritional interventions may help subside this epidemic and save many lives. This review focuses on the nexus between a balanced diet and adaptive immunity, particularly, how a poor diet may lead to compromised immunity resulting in susceptibility to viral infections. Additionally, we discuss how nutrients (vitamins, minerals, trace elements) can be used as a tool to modulate immune response and thus impede viral infections. The study also summarizes nutritional recommendations to combat COVID-19 in different countries and territories as well as dietary sources of those key nutrients. Moreover, different nutritional intervention strategies based on different age groups, physiological and medical conditions were also included, and the challenges of nutritional interventions towards the care of COVID-19 patients are also discussed. Since the availability of a drug or vaccine is still uncertain, a balanced diet or nutrient therapy can be used as a robust strategy to combat COVID-19. Thus, we hope this review may help to make an informed decision with regard to diet choice both at individual level as well as clinical settings.

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“…Micronutrients are minerals and vitamins which are required in very tiny amounts (30) . But together both are extremely important for the normal body functioning in the organism (31) . They are involved in triggering many important biochemical reactions (32) .…”

Section: Importance Of Minerals and Vitamins Consumptionmentioning

confidence: 99%

Covid-19: Information, Transference, Properties of Human Coronaviruses, and Enhancing Immunity by Dietary Recommendations

Dalia I. Hemdan

2021

Indian Journal of Forensic Medicine & Toxicology

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In Wuhan City, China was found a new type of viral infection could be a novel CoV strain (2019-nCoV) which as an acute respiratory syndrome CoV-2 (SARS-CoV-2) and formerly, severe acute respiratory syndrome (SARS). All these emerging infectious diseases are caused great damage to general health.New Coronavirus has diffused very quickly at the world and the World Health Organization has declared it a pandemic. It usually affects people who are immunocompromised. Immunodeficiency often comes from nutritional deficiency and this makes viruses stronger. Therefore, this review focused on the identification of the SARS-CoV-2 virus, its transmission and spread, and the history of Coronavirus. In addition, how to boost immunity by learn about nutrition recommendations and healthy diets during the COVID-19 pandemic.

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The role of zinc and its compounds in leukemia

Cited by 26 publications

References 149 publications

Imaging Tissue Physiology In Vivo by Use of Metal Ion-Responsive MRI Contrast Agents

Imaging Tissue Physiology In Vivo by Use of Metal Ion-Responsive MRI Contrast Agents

Prospects of nutritional interventions in the care of COVID-19 patients

Covid-19: Information, Transference, Properties of Human Coronaviruses, and Enhancing Immunity by Dietary Recommendations

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