The role of yeast m6A methyltransferase in peroxisomal fatty acid oxidation

Yadav, Pradeep Kumar; Rajvanshi, Praveen Kumar; Rajasekharan, Ram

doi:10.1007/s00294-017-0769-5

Cited by 16 publications

(10 citation statements)

References 37 publications

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“…Blood cholesterol is one of the most important heritable risk factors for CAD, and is positively associated with mortality due to CAD ( 132 ). The role of m 6 A modification in lipid metabolism has been reported ( 133 ). Mo et al ( 121 ) investigated the effect of m 6 A-SNPs on lipid levels using GWAS summary datasets of 188,578 individuals.…”

Section: M 6 a And Cardiovascular Diseasementioning

confidence: 99%

Role of m6A RNA methylation in cardiovascular disease (Review)

et al. 2020

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N 6 -methyladenosine (m 6 A) is the most prevalent and abundant type of internal post-transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including mRNAs, rRNAs, tRNAs, long non-coding RNAs and microRNAs, are involved in m 6 A methylation. The biological function of m 6 A modification is dynamically and reversibly mediated by methyltransferases (writers), demethylases (erasers) and m 6 A binding proteins (readers). The methyltransferase complex is responsible for the catalyzation of m 6 A modification and is typically made up of methyltransferase-like (METTL)3, METTL14 and Wilms tumor 1-associated protein. Erasers remove methylation by fat mass and obesity-associated protein and ALKB homolog 5. Readers play a role through the recognition of m 6 A-modified targeted RNA. The YT521-B homology domain family, heterogeneous nuclear ribonucleoprotein and insulin-like growth factor 2 mRNA-binding protein serve as m 6 A readers. The m 6 A methylation on transcripts plays a pivotal role in the regulation of downstream molecular events and biological functions, such as RNA splicing, transport, stability and translatability at the post-transcriptional level. The dysregulation of m 6 A modification is associated with cancer, drug resistance, virus replication and the pluripotency of embryonic stem cells. Recently, a number of studies have identified aberrant m 6 A methylation in cardiovascular diseases (CVDs), including cardiac hypertrophy, heart failure, arterial aneurysm, vascular calcification and pulmonary hypertension. The aim of the present review article was to summarize the recent research progress on the role of m 6 A modification in CVD and give a brief perspective on its prospective applications in CVD.

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Section: M 6 a And Cardiovascular Diseasementioning

confidence: 99%

Role of m6A RNA methylation in cardiovascular disease (Review)

et al. 2020

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“…Additionally, Yadav et al . reported that IME4 gene played a role in the peroxisomal biogenesis, and IME4 gene loss also resulted in the peroxisomal malfunction of fatty acid oxidation 73 .…”

Section: Role Of M6a Modification In Lipid Metabolismmentioning

confidence: 99%

Epigenetic regulation of N6‐methyladenosine modifications in obesity

Sun

Zhang

2021

J of Diabetes Invest

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Obesity is a serious health issue in the world and is related to a higher risk of suffering metabolic diseases. Understanding the molecular basis of obesity is critical to identify new targets to treat obesity and obesity‐associated metabolic diseases. N6‐methyladenosine (m6A) modification is the most common form of ribonucleic acid modification, which has attracted increasing interest of researchers in recent years, as it is reported that m6A has vital functions in diseases and everyday life activities. Recent studies showed that m6A modification was decreased in obese adipose tissue, and appeared to play a regulatory role in many obesity‐associated biological processes, including adipogenesis, lipid metabolism and insulin resistance. In this review, we discussed the emerging advances in m6A modification in obesity to provide a novel therapeutic strategy for fighting against obesity.

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“…This study provides a basis for exploring the role of m 6 A methylation in peroxisomal biology (Table 3). 85…”

Section: Role Of M 6 a Modification In Lipid Metabolism-related Diseasesmentioning

confidence: 99%

Regulatory role and mechanism of m6A RNA modification in human metabolic diseases

Zhang¹,

Chen²,

Zheng³

et al. 2021

Molecular Therapy - Oncolytics

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Metabolic diseases caused by disorders in amino acids, glucose, lipid metabolism, and other metabolic risk factors show high incidences in young people, and current treatments are ineffective. N 6 -methyladenosine (m 6 A) RNA modification is a posttranscriptional regulation of gene expression with several effects on physiological processes and biological functions. Recent studies report that m 6 A RNA modification is involved in various metabolic pathways and development of common metabolic diseases, making it a potential disease-specific therapeutic target. This review explores components, mechanisms, and research methods of m 6 A RNA modification. In addition, we summarize the progress of research on m 6 A RNA modification in metabolism-related human diseases, including diabetes, obesity, non-alcoholic fatty liver disease, osteoporosis, and cancer. Furthermore, opportunities and the challenges facing basic research and clinical application of m 6 A RNA modification in metabolism-related human diseases are discussed. This review is meant to enhance our understanding of the molecular mechanisms, research methods, and clinical significance of m 6 A RNA modification in metabolism-related human diseases.

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The role of yeast m6A methyltransferase in peroxisomal fatty acid oxidation

Cited by 16 publications

References 37 publications

Role of m6A RNA methylation in cardiovascular disease (Review)

Role of m6A RNA methylation in cardiovascular disease (Review)

Epigenetic regulation of N6‐methyladenosine modifications in obesity

Regulatory role and mechanism of m6A RNA modification in human metabolic diseases

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