The role of Wnt/mTOR signaling in spinal cord injury

Abstract

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

The efficacy of intrathecal methyl-prednisolone for acute spinal cord injury: A pilot study

“…Exclusion criteria: Ref. [ 1 ] non-thoracolumbar cause of SCI [ 2 ] penetrating cord injuries [ 3 ] any condition which would not allow intervention in the first 8 h [ 4 ] previous spinal deformity [ 5 ] previously disabled patients [ 6 ] hemodynamically unstable [ 7 ] unconsciousness [ 8 ] any absolute or relative contraindication for Lumbar puncture [ 9 ] the use of high dose steroids within the last month before injury [ 10 ] serious medical condition which drug administration safety is unclear [ 11 ] patients with diabetes mellitus [ 12 ] Pregnant and breastfeeding patients [ 13 ] any systemic immunodeficiency or known infection [ 14 ] any relative or absolute contraindication for high-dose intravenous steroid [ 15 ] any condition which would interfere with consenting [ 16 ] patients with normal sensory and motor function.…”

“…Secondary injuries occur just after the primary damage and are a result of a cascade of signaling and downstream events which ultimately result in free radical formation, apoptosis induction, and inflammation. The recognition of secondary damage had led to various medical and surgical treatments [ [6] , [7] , [8] , [9] , [10] ].…”

Therapeutic Potential of Natural Compounds from Herbs and Nutraceuticals in Alleviating Neurological Disorders: Targeting the Wnt Signaling Pathway

“…94 The Wnt signaling pathway is involved in nerve cell apoptosis, glial scar formation, axon regeneration, and the inflammatory response in secondary SCI. 95 Therefore, regulation of the Wnt signaling pathway may be helpful in the treatment of SCI. After SCI, the regulatory role of the Wnt signaling pathway is reflected in several aspects of secondary SCI.…”

“…182 The Wnt signaling pathway can regulate the development and function of the nervous system and plays an important role in the repair process of SCI. 95 pathological state of the Wnt signaling pathway in SCI may be one of the mechanisms for the treatment of SCI. 183 Notoginsenoside R1 (NGR1) is a natural triterpenoid saponin compound extracted from the traditional Chinese medicine Panax notoginseng.…”

Activation of Wnt/Beta-Catenin Signaling Pathway as a Promising Therapeutic Candidate for Cerebral Ischemia/Reperfusion Injury

“…The Wnt pathway is part of an evolutionarily conserved intracellular signal transduction cascade that regulates multiple processes crucial for cell proliferation, differentiation, migration, and fate decision during development ( Schulte and Bryja, 2017 ; Eubelen et al, 2018 ). Recently, several studies have reported the mechanism by which Wnt/β-catenin signaling is regulated in the adult brain and serves as an endogenous protective mechanism against the central nervous system (CNS) diseases ( Schulte and Bryja, 2017 ; Menet et al, 2020 ; Cheng et al, 2022 ). In this review, we discuss the recent research updates on the regulatory mechanism of the classical Wnt (Wnt/β-catenin) signaling pathway and summarize the biological functions of the cells (endothelial cells, neurons, oligodendrocytes, microglia, and astrocytes) affected by stroke pathology.…”