The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy

Gragnano, Felice; Sperlongano, Simona; Golia, Enrica; Natale, Francesco; Bianchi, Renatomaria; Crisci, Mario; Fimiani, Fabio; Pariggiano, Ivana; Diana, Vincenzo; Carbone, Andreina; Cesaro, Arturo; Concilio, Claudia; Limongelli, Giuseppe; Russo, Maria Giovanna; Calabrò, Paolo

doi:10.1155/2017/5620314

Cited by 167 publications

(164 citation statements)

References 124 publications

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“…We also found an increase in von Willebrand factor (vWF) gene expression in patients with type 2 diabetes. The protein is involved in platelet adhesion and has a role in vascular inflammation and thrombosis [110]. There have been previous studies showing that high levels of VWF are associated with type 2 diabetes [111][112][113].…”

Section: Cytoskeleton Membrane and Adhesion Related Genesmentioning

confidence: 99%

Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes

et al. 2020

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Section: Cytoskeleton Membrane and Adhesion Related Genesmentioning

confidence: 99%

Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes

et al. 2020

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“…ORM2 interacts with TLR2 signaling involved in the pathobiology of sepsis (Sumanth et al, 2019). CFD and VWF are important biomarkers of acute mortality for severe sepsis (Avriel et al, 2014;Gragnano et al, 2017). TIMP1 could be used as prognostic marker for the onset of sepsis (Nino et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Integration Analysis of m6A-SNPs and eQTLs Associated With Sepsis Reveals Platelet Degranulation and Staphylococcus aureus Infection are Mediated by m6A mRNA Methylation

et al. 2020

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Sepsis is a major threat with high mortality rate for critically ill patients. Response to pathogen infection by the host immune system is a key biological process involved in the onset and development of sepsis. Heterogeneous host genome variation, especially single nucleotide polymorphisms (SNPs), has long been suggested to contribute to differences in disease progression. However, the function of SNPs located in noncoding regions remains to be elucidated. Recently, m 6 A mRNA modification levels were revealed to differ at SNPs. As m 6 A is a crucial regulator of gene expression, these SNPs might control genes by changing the m 6 A level on mRNA. To investigate the potential role of m 6 A SNPs in sepsis, we integrated m 6 A-SNP and expression quantitative trait loci (eQTLs) data. Analysis revealed 15,720 m 6 A-cis-eQTLs and 381 m 6 A-trans-eQTLs associated with sepsis. We identified 1321 genes as locations of m 6 A-cis-eQTLs. These were enriched in platelet degranulation and Staphylococcus aureus infection pathways, which are vital for the pathophysiological process of sepsis. We conclude that m 6 A modification of mRNA plays a very important role in sepsis, with m 6 A-cis-eQTLs potentially having the most effect on individual variation in sepsis progression.

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“…Several studies have reported that high plasma vWF levels are associated with endothelial dysfunction and inflammation [32,33], which contribute to the cardiovascular risks. In addition, vWF involves in the pathogenesis of atherosclerosis [34].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta-analysis

Fan

Wang

Peng

et al. 2020

BMC Cardiovasc Disord

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Background: Prediction of major adverse cardiovascular events (MACEs) may offer great benefits for patients with coronary artery disease (CAD). Von Willebrand factor (vWF) is stored in endothelial cells and released into blood plasma upon vascular dysfunction. This meta-analysis was performed to evaluate the prognostic value of plasma vWF levels in CAD patients with MACEs. Methods: A total of 15 studies were included in this meta-analysis through the search in PubMed, Embase and CNKI. Data were collected from 960 patients who had MACEs after CAD and 3224 controls nested without the adverse events. The standard mean difference (SMD) and 95% confidence intervals (95% CI) were calculated using random-effects model. Results: The plasma vWF levels examined at 24 h and 48 h after admission were significantly higher in CAD patients with MACEs than those without. The pooled SMD among the MACEs group and the non-MACEs group was 0.55 (95% CI = 0.30-0.80, P < 0.0001) and 0.70 (95% CI = 0.27-1.13, P = 0.001), respectively. However, no significant difference was found in plasma vWF levels on admission between the two groups. Conclusion: Plasma vWF level in CAD patients examined at 24 h and 48 h after admission might be an independent prognostic factor for MACE.

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The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy

Cited by 167 publications

References 124 publications

Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes

Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes

Integration Analysis of m6A-SNPs and eQTLs Associated With Sepsis Reveals Platelet Degranulation and Staphylococcus aureus Infection are Mediated by m6A mRNA Methylation

Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta-analysis

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