The role of volume transmission of adaptogenic signals in forming the adaptive reactions of the brain

Abstract

This review presents published data and results from our own studies providing evidence for the important role of volume, non-synaptic transmission of adaptogenic signals in the mechanisms forming the long-term adaptive reactions of the brain. The importance of chemical factors involved in volume transmission and secreted by cells in this process is discussed. Special attention is paid to peptides-possible mediators of volume transmission of adaptive-type signals. Evidence has been obtained for the presence of peptides and their role in the mechanism of development of adaptive brain reactions of different origins, especially those arising in response to tetanic stimulation of neurons and transient hypoxic stress. An original method for testing for the effects of neuromodulator factors released by cells in donor slices subjected to these treatments on recipient slices was used to show that these factors had pronounced effects on synaptic transmission and could induce long-term potentiation of synaptic transmission, protecting against functional derangements due to prolonged anoxia. Blockade of protein synthesis in donor slices subjected to adaptogenic treatments suppressed the appearance of these effects. The review concludes with a discussion of the mechanisms of interaction of the synaptic and volume transmission of signals involved in forming long-term adaptive brain reactions.

Calcium Transients in the Model of Rapidly Induced Anoxic Tolerance in Rat Cortical Slices: Involvement of NMDA Receptors

“…Moreover, NMDA receptors expressed in cerebellar Bergman glial cells appeared to be impermeable to Ca 2+ [29]. In addition, our electrophysiological studies performed in vitro under the same experimental conditions or in vivo on cats demonstrated neuroprotective effects of anoxic preconditioning [30][31][32]. Also, in our recent studies, inhibition of NMDA receptors by oxidation of its redox modulatory site influenced in similar way anoxia-evoked fluorescence signals and electrophysiological responses recorded from neuronal cells [33,34].…”