The Role of Vitamin E in Biological Membranes

Diplock, A. T.

doi:10.1002/9780470720820.ch4

Cited by 41 publications

(7 citation statements)

References 11 publications

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“…The unsaturated double bonds of membrane PUFA are inherently unstable and readily attacked by peroxides and other forms of reactive oxygen species (ROS) (Putnam and Comben, 1987). This process tends to produce a chain reaction called lipid peroxidation (Diplock, 1983) and more free radicals and hydroperoxides are formed (Figure 2). The α-tocopherol acts as a scavenger of free radicals and prevents this runway chain reaction (Burton and Traber, 1990;Rock et al, 1996).…”

Section: Resultsmentioning

confidence: 99%

Status of Lipid Peroxidation in Normal Cycling and 慣-Tocopherol Supplemented Anestrus Buffalo Heifers (Bubalus bubalis)

Kahlon¹,

Sodhi²,

Singh³

2006

Asian Australas. J. Anim. Sci

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The present study was undertaken to analyze the status of erythrocytic malonyl dialdehyde (MDA) as an index of lipid peroxidation in normal cycling and α-tocopherol supplemented anestrus buffalo heifers. Before supplementation, the blood samples were collected at weekly interval in anestrus and normal cycling buffalo heifers and data from four samples was pooled to establish presupplementation base line. Thereafter, the blood samples from anestrus and α-tocopherol supplemented anestrus buffalo heifers were taken at fortnightly interval for 12 weeks during supplementation and for four weeks during the post-supplementation period. The presupplementation endogenous erythrocytic MDA, 0.3% H 2 O 2 induced-erythrocytic MDA and 1.5% H 2 O 2 induced-erythrocytic MDA levels (nmol/g Hb) increased significantly (p<0.05) in anestrus heifers (372.3±5.0, 564.4±5.7, 862.4±8.5) when compared to normal cycling animals (289.6±3.0, 508.2±6.0, 777.7±4.9). Oral supplementation of 3,000 mg of α-tocopherol per week per animal in anestrus heifers resulted in a progressive and significant (p<0.01) decline in erythrocytic MDA levels. These observations implied that supplementation of α-tocopherol to anestrus buffalo heifers ameliorated their antioxidant status by alleviating the effects of oxidative stress.

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Section: Resultsmentioning

confidence: 99%

Status of Lipid Peroxidation in Normal Cycling and 慣-Tocopherol Supplemented Anestrus Buffalo Heifers (Bubalus bubalis)

Kahlon¹,

Sodhi²,

Singh³

2006

Asian Australas. J. Anim. Sci

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“…The Anova table reveals that SO 2 and variety were highly significant in case of Lentil while only SO 2 variable was highly significant in Mung bean rest other interaction were not very significant. -tocopherol (Vitamin E) probably is the most important antioxidant that is incorporated into the lipid membrane of the cells (Diplock, 1983). Chloroplast contain large amount of a -tocopherol to protect the membrane against oxidative damage, since most of the fatty acids of chloroplast lipids are unsaturated C 18 fatty acid (Halliwell, 1984).…”

Section: Dry Weight Study (D Wt)mentioning

confidence: 99%

Oxidative stress mitigation studies in two pulse crops

Jain¹,

Kumawat²,

Patel

2010

ECJ

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Sulphur dioxide is well studied phytotoxic gaseous pollutant. It is one of the main oxidative gas, which is known for the production of various free oxyradicals during its oxidation from unstable from sulphite (SO3--) to stable from sulphate (SO4-) within the life. The oxiradical are initiated by light and mediated by photosynthesis electron transport chain. The generated free radicals react with and cause oxidative damage to various biological molecules and cell organelles.The mechanism of plant tolerance to air pollutants exposure is probably biological rather than biophysical air pollutant have been shown to affect the level of defense enzymes as well as than of antioxidant biomolecules present within the plant cells. Protection of sensitive plant species against the oxidative stress may be achieved through various means such as coating the leaf surface and providing physical and/or chemical protection, through alteration of plant metabolism etc.In the present study, an attempt to made to infuse scavenging potential exogenously in cultivars of two pulse crops namely Lentil (Lens culinaris L medic) and Mung bean (Vigna radiate L.) using certain antioxidants (α – Tocopherol, ascorbic acid and diphenyl amine). Seeds of both the crops and their selected susceptible cultivars were invigorated exogenously with different antioxidant using dry permeation technique. The plantlets generated were subjected to two different SO2 concentration (655 and 2620 g/m3) in open top chambers (OCT) and were evaluated for their response through certain physiological and biochemical parameters. Cultivars JM-721 (Mung bean) and SLC-2 (Lentil) appered to be slightly tolerant than the other respective suseptible cultivars studied (MI–24-91 and Sehore 84 -8). The study trend in general suggests that lower SO2 concentration was slightly beneficial to both the cultivars of both the crops. All the three antioxidant treatment were comparatively effective in most of the parameters. The treatment affectively however differed for the two cultivars of the same crop. Diphenylamine appeared to be promising in most of the parameters, however most effective was α – Tocopherol followed ascorbic acid.

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“…Vitamin E deficiency predisposes to peroxidation of polyunsaturated fatty acids (PUFA) in structural cell membrane lipids, which may induce neuronal damage (4) and lower the availability of highly unsaturated long‐chain polyunsaturated fatty acids considered important for early neural development (5). Therefore, the efficacy of supplementation with parenteral (6,7) and enteral lipid‐soluble vitamin E preparations (8) on high lipid peroxide levels in cholestatic children has been studied and revealed conflicting results.…”

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confidence: 99%

Treatment of Cholestatic Children with Water‐soluble Vitamin E (α‐Tocopheryl Polyethylene Glycol Succinate): Effects on Serum Vitamin E, Lipid Peroxides, and Polyunsaturated Fatty Acids

Socha,

Koletzko,

Pawlowska

et al. 1997

J. pediatr. gastroenterol. nutr.

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Background:Treatment of vitamin E‐deficient cholestatic children with water‐soluble α‐tocopherol polyethylene glycol succinate (TPGS) was previously shown to normalize vitamin E status and to improve neurological outcome.Methods:Because vitamin E plays an important role as a free‐radical scavenger, we studied the effects of long‐term TPGS supplementation on lipid peroxidation and polyunsaturated fatty acid status in 15 children ages 9 months‐3.4 years (median, 1.3 years) with chronic cholestasis with low serum vitamin E concentrations [1.95 (0.8‐3.7) mg/L; median (1st‐3rd quartile)]. The previous supplementation of α‐tocopherol was replaced by a 20% solution of TPGS in one daily dose of 20 IU/kg. Serum α‐tocopherol, plasma lipid peroxides expressed as thiobarbiturate reactive substance concentration (TBARS) and plasma phospholipid fatty acid profile were estimated at baseline and again after 1 month in all 15 patients, and after 1 year of TPGS therapy in 11 patients.Results:α‐Tocopherol was significantly increased after 1 month [6.9 (4.4‐8.4) mg/L; p = 0.008] and rose further after 1 year [9.7 (7.2‐14.9) mg/L]; similar results were obtained for the ratio vitamin E/total lipids. TBARS concentrations were significantly higher in cholestatic children at baseline [2.9 (1.5‐3.32) nmol/ml] than in a control group [1.2 (1.1‐1.3) nmol/ml; p = 0.0006], but were not changed significantly during TPGS therapy [after 1 year 2.34 (1.9‐3.0) nmol/ml]. Compared with controls, the contributions of polyunsaturated fatty acids to total phospholipid fatty acids were markedly decreased in cholestatic patients at baseline [27.7 (22.4‐31.5)% versus 36.9 (34.5‐39.0)%; p = 0.001] and did not show major changes after 1 year of TPGS supplementation.Conclusions:We conclude that oral TPGS supplementation of cholestatic children can quickly normalize serum vitamin E levels but does not improve the increased lipid peroxidation and poor polyunsaturated fatty acid status.

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The Role of Vitamin E in Biological Membranes

Cited by 41 publications

References 11 publications

Status of Lipid Peroxidation in Normal Cycling and 慣-Tocopherol Supplemented Anestrus Buffalo Heifers (Bubalus bubalis)

Status of Lipid Peroxidation in Normal Cycling and 慣-Tocopherol Supplemented Anestrus Buffalo Heifers (Bubalus bubalis)

Oxidative stress mitigation studies in two pulse crops

Treatment of Cholestatic Children with Water‐soluble Vitamin E (α‐Tocopheryl Polyethylene Glycol Succinate): Effects on Serum Vitamin E, Lipid Peroxides, and Polyunsaturated Fatty Acids

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