The Role of Vitamin D in Inflammatory Bowel Disease – Assessing Therapeutic and Preventive Potential of Supplementation and Food Fortification

Leskovar, Dunja; Meštrović, Tomislav; Barešić, Anja; Kraljević, Ivana; Panek, Michał; Paljetak, Hana Čipčić; Perić, Mihaela; Matijašić, Mario; Rogić, Dunja; Barišić, Ana; Kelečić, Dina Ljubas; Bender, Darija Vranešić; Krznarić, Željko; Verbanac, Donatella

doi:10.17113/ftb.56.04.18.5805

Cited by 6 publications

(9 citation statements)

References 68 publications

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“…Dietary supplements are generally considered to be a rapid form of VitD supplementation, and the total intake of VitD always reflects the combined contribution of the food source and the supplement to the diet. VitD can be found in VitD 2 or VitD 3 ; however, the former is rarely used as a fortifier in dietary supplements [90, 91]. Increasing VitD in foods may be the best way to increase intake, but it does not significantly increase serum 25(OH)D levels.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency associated with Crohn’s disease and ulcerative colitis: a meta-analysis of 55 observational studies

Liu

Luo

et al. 2019

J Transl Med

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Purpose To investigate the association of serum levels of 25(OH)D and 1,25(OH)2D3 in healthy and non-healthy controls with Crohn’s disease (CD) and ulcerative colitis (UC). Methods Three electronic databases: PubMed, EMbase and EBSCOhost CINAHL, were searched for observational studies to measure the relationship between serum levels of vitamin D (VitD) and CD (or UC). Results Fifty-five studies were included in the meta-analysis. We found that mean serum 25(OH)D levels in patients with CD were significantly lower than those in healthy controls (MD: − 3.17 ng/mL; 95% CI − 4.42 to − 1.93). Results from the meta-analysis examining 1,25(OH)2D3 levels in Crohn’s patients revealed higher levels in the CD group than in healthy (MD: 3.47 pg/mL; 95% CI − 7.72 to 14.66) and UC group (MD: 5.05 pg/mL; 95% CI − 2.42 to 12.52). Serum 25(OH)D levels were lower in the UC group than in the healthy control group (MD: − 2.52 ng/mL; 95% CI − 4.02 to − 1.02). In studies investigating the level of 1,25(OH)2D3 in UC and healthy control groups, the level of 1,25(OH)2D3 in the UC groups were found to be higher than that in the control groups (MD: 3.76 pg/mL; 95% CI − 8.36 to 15.57). However, the 1,25(OH)2D3 level in patients with UC was lower than that in CD groups (MD: − 6.71 pg/mL; 95% CI − 15.30 to 1.88). No significant difference was noted between CD patients and UC patients in terms of average serum 25(OH)D levels. Conclusions This study found that VitD levels were inversely related to CD and UC. Serum levels of 25(OH)D were lower in patients with CD and UC than in healthy people, and more than half of the patients had insufficient vitamin D levels. The serum level of 1,25(OH)2D3 in both the CD and UC groups was higher than that in healthy people.

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Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency associated with Crohn’s disease and ulcerative colitis: a meta-analysis of 55 observational studies

Liu

Luo

et al. 2019

J Transl Med

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“…Este último es la principal fuente de vitamina D de la naturaleza, dado que puede ser sintetizada, de manera endógena, mediante la luz ultravioleta procedente del sol [28]. Además, se obtiene de forma exógena, mediante la ingesta alimentaria, representando 20% de los requerimientos diarios [4,6].…”

Section: Vitamina Dunclassified

“…La vitamina D se encuentra ampliamente presente en los tejidos, obteniéndose mediante la exposición de la piel a luz ultravioleta del sol y a través de la ingesta dietética [4,5]. Las principales fuentes de este nutriente son los lácteos, yema de huevo, carnes rojas y pescados [6].…”

Section: Introductionunclassified

“…Algunos estudios observaron que la vitamina D está implicada en la regulación de la respuesta inmunológica [2,7,8], mejorando la composición de la microbiota del colon y las funciones de la barrera intestinal, cumpliendo un importante rol en la enfermedad inflamatoria intestinal [6,9]. Diversos estudios han observado que los altos niveles séricos de vitamina D, disminuye la incidencia de recidivas del cuadro clínico [10,11].…”

Section: Introductionunclassified

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Vitamin D supplementation in inflammatory bowel disease: a narrative review

Zepeda¹,

Pérez²,

Doepking³

2022

Medwave

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Inflammatory bowel disease is a chronic disorder characterized by exacerbation and remission periods, and its worldwide incidence has increased in recent decades. Vitamin D is involved in immune regulation and improves barrier functions and intestinal microbiota. Studies have observed that high vitamin D levels decrease relapses and improve the clinical course of inflammatory bowel disease. The objective of this review was to analyze the evidence on vitamin D supplementation in adult patients with inflammatory bowel disease. Among inactive patients, the studies administrating less than 2000 international units per day of vitamin D did not find any beneficial effects. However, those supplementing 2000 international units of vitamin D per day increased serum levels and reduced disease activity. In patients with active disease, doses between 5000 to 10 000 international units per day reduced symptomatology. This review showed that vitamin D supplementation above 2000 international units per day among inactive patients with inflammatory bowel disease, and between 5000 to 10 000 international units per day among those in the active stage, shows potential benefits on the disease.

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“…No entanto, em mais de 50% dos pacientes ocorrem manifestações perianais, bem como manifestações extraintestinais que aparecem de forma isolada ou associada, afetando mais continuamente a pele, fígado, olhos, articulações e trato urinário. Esses distúrbios são notórios em indivíduos de qualquer idade, mas o diagnóstico é mais frequentemente averiguado na segunda ou terceira década da vida (LESKOVAR et al, 2018).…”

Section: Doença De Crohnunclassified

Implications of Vitamin D Insufficiency/Deficiency in Autoimmune Diseases: A Review

Alves¹,

Cesilio²,

Alves³

et al. 2021

Rev. UNINGÁ

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A vitamina D é um hormônio esteroide lipossolúvel com amplitude de efeitos biológicos que extrapolam a regulação do metabolismo do cálcio e da saúde óssea, que alcança preponderante papel na manutenção da homeostase sistêmica, relacionado ao crescimento, diferenciação e apoptose celular, regulação dos sistemas imunológico, cardiovascular e muscular e ao metabolismo da insulina; além de participar da modulação direta ou indireta de cerca de 3% do genoma humano. Frente o exposto, e considerando as graves complicações advindas da deficiência de vitamina D para a saúde e qualidade de vida, propôs-se neste trabalho um estudo descritivo, o qual relaciona a insuficiência/deficiência desta vitamina a algumas doenças autoimunes como o lúpus eritematoso sistêmico, o diabetes mellitus, a esclerose múltipla, a artrite reumatoide e a doença inflamatória intestinal (Doença de Crohn). Este estudo foi desenvolvido a partir de 58 artigos, dentre os quais incluem os de revisão, artigos originais de pesquisas clínicas e experimentais, publicados entre 2008 a 2020, obtidos a partir da pesquisa no banco de dados Pubmed®, Google Acadêmico e Scientific Electronic Library Online (SCIELO). Com base nos estudos relacionados às doenças autoimunes, pode-se concluir que a vitamina D exibe função imunomoduladora crucial, garantindo eficiente sistema de proteção. Estudos que versam sobre a suplementação de vitamina D, tanto para a prevenção quanto para o tratamento das doenças autoimunes existentes são necessários e de grande valia para o entendimento dessas implicações.

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The Role of Vitamin D in Inflammatory Bowel Disease – Assessing Therapeutic and Preventive Potential of Supplementation and Food Fortification

Cited by 6 publications

References 68 publications

Vitamin D deficiency associated with Crohn’s disease and ulcerative colitis: a meta-analysis of 55 observational studies

Vitamin D deficiency associated with Crohn’s disease and ulcerative colitis: a meta-analysis of 55 observational studies

Vitamin D supplementation in inflammatory bowel disease: a narrative review

Implications of Vitamin D Insufficiency/Deficiency in Autoimmune Diseases: A Review

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