The role of vitamin D in muscle strength among the elderly

Silva, Patrícia Zambone da; Schneider, Rodolfo Herberto

doi:10.5935/0104-7795.20160019

Cited by 2 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Resting heart rate variability was advocated by some authors as a sensitive and specific method for diagnosis of cardiovascular dysautonomia. Besides that, it is easier to be performed than dynamic tests and does not need patient collaboration (28)(29)(30)(31)(32)(33)(34)(35). Takase et al (28) found that a cut-off point <30ms in SDNN parameter has a sensitivity of 72% and specificity of 92% for CAN diagnosis in patients with type 2 diabetes, while Ziegler et al (30) showed that HF index was more sensitive than functional tests to detect precocious autonomic disorder in patients with diabetes, using 0,892 as a cut-off.…”

Section: Discussionmentioning

confidence: 99%

Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes

et al. 2020

View full text Add to dashboard Cite

BackgroundCardiovascular autonomic neuropathy (CAN) is associated with diabetes mellitus, increasing morbidity and mortality. Some cross-sectional studies associated CAN with low 25-hydroxyvitamin D levels. The aim of our study was to evaluate the effect of high-dose vitamin D (VD) supplementation on CAN in Type 1 Diabetes Mellitus (T1DM) patients.MethodsWe performed a prospective study with 23 patients diagnosed with T1DM and CAN. Subjects with VD levels <30 ng/ml received 10,000 IU/day; the ones with VD levels between 30–60 ng/ml were given 4,000 IU/day for 12 weeks.ResultsThere was an improvement in CAN parameters related to resting heart rate variability, such as time domain parameters [Maximum RR interval (0.77 ± 0.11 vs 0.94 ± 0.51 s, p <0.05), Mean length of regular RR intervals (0.71 ± 0.10 vs 0.76 ± 0.09 s, p <0.05) and Standard deviation of all NN intervals (0.02 ± 0.01 vs 0.03 ± 0.02 s; p <0.01)] and frequency domain parameters [Low Frequency (1.9 ± 0.5 vs 2.5 ± 0.9 s, p < 0.001), Total Power (2.5 ± 0.4 vs 2.8 ± 0.6 s, p <0.05)]. In addition, there was a correlation between absolute VD level variation and posttreatment High Frequency (%), as well as among percent variation in VD level and end-of-study Low Frequency/High Frequency ratio (r=0.6, p<0.01; r= -0.5, p<0.05, respectively).ConclusionOur pilot study is the first to suggest a strong association between high-dose vitamin D supplementation and improved cardiovascular autonomic neuropathy in T1DM patients. It occurred without any variation in HbA1C, blood pressure levels, lipids, and insulin dose.Clinical Trial Registrationhttp://www.isrctn.com/ISRCTN32601947, identifier ISRCTN32601947.

show abstract

Section: Discussionmentioning

confidence: 99%

Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes

et al. 2020

View full text Add to dashboard Cite

show abstract

Prevalência Da Deficiência De Vitamina B12 Em Pacientes De Um Laboratório De Análises Clínicas De Francisco Beltrão, Pr.

et al. 2020

View full text Add to dashboard Cite

Compostos de cobalamina, designados como vitamina B12, possuem núcleo de corrina que apresenta elemento central o cobalto. Alimentos fontes de vitamina B12 são carnes, leites e ovos, mas podem ser sintetizados pelas bactérias da microbiota intestinal. As enzimas que necessitam de vitamina B12 como cofator são a metionina sintase e L-metilmalonil-coA mutase. A deficiência da vitamina B12 pode causar neuropatia periférica e sintomas psiquiátricos. O objetivo deste trabalho foi estabelecer a prevalência da deficiência de vitamina B12 em indivíduos que fizeram exame em um laboratório de análises clínicas de Francisco Beltrão, Paraná. Dados foram obtidos do relatório de resultados de exames do laboratório. O valor médio de vitamina B12 foi de 243,7±101,1 pg/mL e 7,6% estavam fora dos valores de referência. Já o valor médio de vitamina D foi de 31,1±43,8 ng/mL e 21,4% encontravam-se fora dos valores de referência. Dos 85 idosos participantes, 3,5% estavam abaixo e 7,0% acima dos valores de referência para vitamina B12, entre os 47 idosos que realizaram exame de vitamina D, a prevalência de hipovitaminose foi de 70,2%. Para evitar problemas pela deficiência destas vitaminas, estas devem estar presentes em quantidade adequadas na alimentação, ou quando necessário a suplementação pode ser utilizada.

show abstract

The role of vitamin D in muscle strength among the elderly

Cited by 2 publications

References 21 publications

Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes

Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes

Prevalência Da Deficiência De Vitamina B12 Em Pacientes De Um Laboratório De Análises Clínicas De Francisco Beltrão, Pr.

Contact Info

Product

Resources

About