The role of vitamin D in allergic rhinitis

Tian, Huiqin; Cheng, Long

doi:10.5415/apallergy.2017.7.2.65

Cited by 41 publications

(43 citation statements)

References 55 publications

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“…Its other important activities concern the stimulation of Treg cell proliferation down-regulating the likelihood of allergic reactions, moreover the vitamin improves the integrity of the airway epithelial barrier [26, 27]. Many studies report that adequate vitamin D concentration improves the course of AR [28]; however, no such correlation was found between vitamin D level and MCT in the present study indicating that mucociliary clearance does not depend on vitamin D level.…”

Section: Discussioncontrasting

confidence: 55%

Impact of Allergic Rhinitis on Nasal Mucociliary Clearance Time in Children

Mikolajczyk

Janukowicz

Majewska

et al. 2019

Int Arch Allergy Immunol

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Background: Mucociliary clearance is one of the most important protective functions of the airway. Previous studies, checking the influence of allergic rhinitis (AR) on mucociliary clearance time (MCT), were made on small patient groups and brought contradictive results. Objectives: The aim of the study is to confirm whether AR in children influences MCT. Methods: The examined group consisted of 842 AR children. A total of 96 children with no history of allergy rhinitis served as a comparative group. All patients underwent saccharin and skin prick tests and tests for blood eosinophilia, nasal eosinophilia, vitamin D3 serum concentration, total and specific IgE serum concentration. Results: Nasal MCT was significantly longer in AR patients (mean ± SD: 10.5 ± 5.65 min) compared to controls (mean ± SD: 7.25 ± 4.3 min). Percentage of eosinophils in nasal smears in patients was significantly higher compared to controls and a weak, but significant positive correlation was observed between the percentage and MCT (r > 0.10, p < 0.008). Patients with intermittent and persistent moderate/ severe AR had significantly longer MCT and higher eosinophilia in nasal smears compared both to patients with intermittent and persistent mild RA and controls. No correlation was observed between MCT and: participant’s age, total serum IgE, vitamin D3 serum concentration, absolute number or percentage of eosinophils in blood, prick test results or duration of illness. Conclusions: AR affects the mucociliary clearance in children, and its deterioration is related to more severe rhinitis with higher intensity of local nasal inflammation, reflected in nasal smear eosinophilia.

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Section: Discussioncontrasting

confidence: 55%

Impact of Allergic Rhinitis on Nasal Mucociliary Clearance Time in Children

Mikolajczyk

Janukowicz

Majewska

et al. 2019

Int Arch Allergy Immunol

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“…1 The prevalence of confirmed AR in European adults was reported as between 17% and 28.5%. 1,3 Although the morbidity and mortality are relatively low, AR has remarkable burden and costs.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Serum 25-Hydroxyvitamin D3 Levels on Allergic Rhinitis

et al. 2019

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We aimed to clarify the relation between allergic rhinitis and the serum levels of 25-hydroxivitamin D in the adult population. The study group consisted of 86 patients with allergic rhinitis who were diagnosed with the help of history of allergy, positive signs for allergy, blood samples, and positive skin prick tests; while the control group included 43 age- and sex-matched healthy volunteers with negative skin prick tests. The demographic data, medical history, findings in the physical examinations, serum levels of total immunoglobulin E (IgE) and 25-hydroxyvitamin D, and skin prick test results of the groups were noted. A total of 129 patients fulfilling the necessary criteria were enrolled. The median serum 25-hydroxyvitamin D levels in the study group were significantly lower compared to the control group ( P = .014). In the study group, median serum vitamin D levels were significantly higher in men, compared to women ( P = .03). There was a significant negative correlation between IgE and vitamin D levels in the allergic rhinitis group ( P = .028, r = −0.246). This study showed that patients with allergic rhinitis might be more vulnerable to have lower serum levels of vitamin D. Thus, vitamin D supplementation as an adjunctive therapy may be considered in those patients.

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“…Allergic rhinitis (AR) is the most common non-infectious rhinitis globally and is associated with sneezing, cough, and flu-like symptoms. It is an immune-mediated phenomenon and is initiated when the allergen is exposed to the nasal mucosa, which potentiates an 1 2 3 4 immunoglobulin E (IgE)-mediated inflammatory cascade [1]. It plays a significant role in debilitating general health and everyday routine.…”

Section: Introductionmentioning

confidence: 99%

“…It plays a significant role in debilitating general health and everyday routine. AR affects school attendance, workplace performance, and social life [1]. Even after the profound impact on the quality of life and healthcare economics, there hasn't been much control over the condition, which is due to its unclear pathogenesis [1].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and Serum Immunoglobulin E Levels in Allergic Rhinitis: A Case-control Study from Pakistan

Ansari

Memon²,

Brohi

et al. 2019

Cureus

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Introduction Allergic rhinitis (AR) is the most common non-infectious rhinitis and is associated with sneezing, cough, and flu-like symptoms. The exact pathophysiology of AR remains uncertain. The deficiency of vitamin D 3 has been documented as a probable cause of allergic conditions due to its role in immunomodulation. The aim of this study was to evaluate the role of vitamin D 3 deficiency in allergic rhinitis. Methods This case-control study was conducted with 50 patients of AR and 50 healthy individuals. Serum immunoglobulin (Ig) E and vitamin D 3 levels were measured in all study participants. Data were analyzed using SPSS v. 21.0 (IBM Corp., Armonk, NY). Results Mean serum IgE levels in the AR group were 553.5 ± 53.9 IU/L as compared to 219.4 ± 32.1 IU/L in the control group (p <0.0001). AR patients had mean serum vitamin D levels of 14.8 ± 7.4 ng/mL as compared to 19.1 ± 6.6 ng/mL in the control group (p=0.002). Only 10% of participants in the AR group had adequate serum vitamin D levels as compared to 26% in the controls (p=0.08). Conclusion Vitamin D deficiency was present in both study groups. The AR group had significantly lower mean levels of serum vitamin D than the control group. However, upon stratification, the differences were insignificant.

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The role of vitamin D in allergic rhinitis

Cited by 41 publications

References 55 publications

Impact of Allergic Rhinitis on Nasal Mucociliary Clearance Time in Children

Impact of Allergic Rhinitis on Nasal Mucociliary Clearance Time in Children

The Impact of Serum 25-Hydroxyvitamin D3 Levels on Allergic Rhinitis

Vitamin D and Serum Immunoglobulin E Levels in Allergic Rhinitis: A Case-control Study from Pakistan

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