The Role of Vitamin D in Hematologic Disease and Stem Cell Transplantation

Abstract

Vitamin D is a steroid hormone with a broad range of biological effects ranging from the classical role as a mediator of calcium and phosphate balance to cellular differentiation and immune modulation. These effects impact normal and dysfunctional hematopoietic and immune function, which may allow an avenue for improved treatment and support of patients suffering from hematologic disorders. In this review, we will summarize the role of vitamin D in normal hematopoiesis, discuss ways in which vitamin D may improve outcomes, and discuss a potential role of vitamin D for treating hematologic disorders and modulating the immune system to improve the outcome of allogeneic stem cell transplant.

1,25-dyhydroxyvitamin D3 Attenuates l-DOPA-Induced Neurotoxicity in Neural Stem Cells

“…2). These findings are similar to those of previous studies, which showed that calcitriol decreased cell proliferation by interfering with the cell cycle and by regulating the expression of cell cycle genes [53,54]. Therefore, the restorative effect of calcitriol on NSC proliferation might be due to the prevention of the anti-proliferative effects of L-DOPA via the modulation of an intracellular pathway rather than via an enhancement of the proliferative activity of NSCs.…”

“…Furthermore, VDR has been identified in the brain and spinal cord neurons of developing fetal rats, indicating that calcitriol may play important roles in neurogenesis [51,52]. However, various studies also have demonstrated that vitamin D inhibits the proliferation of cancer-derived cells and normal primary cultured cells by affecting the cell cycle [53,54]. Recently, Klotz et al reported an anti-proliferative effect of calcitriol on human mesenchymal stem cells [55].…”

A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing

“…Although other vitamin D family members have been shown to have cell growth-promoting effects on the hematopoietic system and have been specifically utilized in the management of anemia (Christakos et al., 2013, Erturk et al., 2002, Hall and Juckett, 2013, Hewison et al., 2001). In addition, Cortes et al.…”

“…There are increasing data that vitamin D plays a positive role in HCT (Hall and Juckett, 2013). Hansson et al.…”

Metadichol® and Red Cell Distribution Width (RDW) in CKD patients

“…have shown that there is an inverse association between vitamin D levels and EPO CKD patients [25]. Vitamin D supplementation and Paricalcitol therapy have been shown to lead to improvement in biomarkers of inflammation [30][31][32][33][34][35][36][37][38][39][40][41][42].…”