The Role of Vitamin C in Two Distinct Physiological States: Physical Activity and Sleep

Otocka-Kmiecik, Aneta; Król, Aleksandra

doi:10.3390/nu12123908

Cited by 11 publications

(9 citation statements)

References 130 publications

(151 reference statements)

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“…Fruits are rich in vitamin C, which is an antioxidant that scavenges free radicals. A growing body of evidence supports that vitamin C may have a role in sleep health due to the association between free radical formation and oxidative stress with sleep and sleep-related problems [ 32 ]. In addition, fruits are rich in some B-complex vitamins, which are associated with sleep outcomes.…”

Section: Discussionmentioning

confidence: 99%

Mediterranean Dietary Patterns Related to Sleep Duration and Sleep-Related Problems among Adolescents: The EHDLA Study

et al. 2023

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Purpose: The aim of the present study was to examine the association of adherence to the Mediterranean Diet (MD) and its specific components with both sleep duration and sleep-related disorders in a sample of adolescents from the Valle de Ricote (Region of Murcia, Spain). Methods: This cross-sectional study included a sample of 847 Spanish adolescents (55.3% girls) aged 12–17 years. Adherence to the MD was assessed by the Mediterranean Diet Quality Index for Children and Teenagers. Sleep duration was reported by adolescents for weekdays and weekend days separately. The BEARS (Bedtime problems, Excessive daytime sleepiness, Awakenings during the night, Regularity and duration of sleep, and Sleep-disordered breathing) screening was used to evaluate issues related to sleep, which include difficulties at bedtime, excessive drowsiness during the day, waking up frequently during the night, irregularity, length of sleep, and breathing issues while sleeping. Results: Adolescents who presented a high adherence to the MD were more likely to meet the sleep recommendations (OR = 1.52, 95% CI 1.12–2.06, p = 0.008) and less likely to report at least one sleep-related problem (OR = 0.56, 95% CI 0.43–0.72, p < 0.001). These findings remained significant after adjusting for sex, age, socioeconomic status, waist circumference, energy intake, physical activity, and sedentary behavior, indicating a significant association of adherence to the MD with sleep outcomes (meeting sleep recommendations: OR = 1.40, 95% CI 1.00–1.96, p = 0.050; sleep-related problems: OR = 0.68, 95% CI 0.50–0.92, p = 0.012). Conclusions: Adolescents with high adherence to the MD were more likely to report optimal sleep duration and fewer sleep-related problems. This association was more clearly observed for specific MD components, such as fruits, pulses, fish, having breakfast, dairies, sweets, and baked goods/pastries.

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Section: Discussionmentioning

confidence: 99%

Mediterranean Dietary Patterns Related to Sleep Duration and Sleep-Related Problems among Adolescents: The EHDLA Study

et al. 2023

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“…In general, vitamin C and E should be supplemented in small amounts. If excess levels of these antioxidants are achieved, they can have a detrimental effect and result in a rise in oxidation [ 87 ].…”

Section: Properties Of Paraoxonasementioning

confidence: 99%

Effect of Carotenoids on Paraoxonase-1 Activity and Gene Expression

Otocka-Kmiecik

2022

Nutrients

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Paraoxonase 1 (PON1) is an antioxidant enzyme attached to HDL with an anti-atherogenic potential. It protects LDL and HDL from lipid peroxidation. The enzyme is sensitive to various modulating factors, such as genetic polymorphisms as well as pharmacological, dietary (including carotenoids), and lifestyle interventions. Carotenoids are nutritional pigments with antioxidant activity. The aim of this review was to gather evidence on their effect on the modulation of PON1 activity and gene expression. Carotenoids administered as naturally occurring nutritional mixtures may present a synergistic beneficial effect on PON1 status. The effect of carotenoids on the enzyme depends on age, ethnicity, gender, diet, and PON1 genetic variation. Carotenoids, especially astaxanthin, β-carotene, and lycopene, increase PON1 activity. This effect may be explained by their ability to quench singlet oxygen and scavenge free radicals. β-carotene and lycopene were additionally shown to upregulate PON1 gene expression. The putative mechanisms of such regulation involve PON1 CpG-rich region methylation, Ca(2+)/calmodulin-dependent kinase II (CaMKKII) pathway induction, and upregulation via steroid regulatory element-binding protein-2 (SREBP-2). More detailed and extensive research on the mechanisms of PON1 modulation by carotenoids may lead to the development of new targeted therapies for cardiovascular diseases.

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“…Vitamin C or ascorbic acid is a water-soluble antioxidant that cannot be synthesized in humans and must be obtained from dietary intake of fruits and vegetables, particularly citrus fruits (grapefruit, orange) [130]. In addition to its antioxidant role as a free radical scavenger, vitamin C is a cofactor in the synthesis of a number of compounds including serotonin, dopamine and noradrenaline, important neurotransmitters in the sleep mechanism [131,132].…”

Section: Micronutrientsmentioning

confidence: 99%

Nutraceuticals as Potential Targets for the Development of a Functional Beverage for Improving Sleep Quality

et al. 2021

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Functional beverages can be a valuable component of the human diet with the ability to not only provide essential hydration but to deliver important bioactive compounds that can contribute to chronic disease treatment and prevention. One area of the functional beverage market that has seen an increase in demand in recent years are beverages that promote relaxation and sleep. Sleep is an essential biological process, with optimal sleep being defined as one of adequate duration, quality and timing. It is regulated by a number of neurotransmitters which are, in turn, regulated by dietary intake of essential bioactive compounds. This narrative review aimed to evaluate the latest evidence of the sleep promoting properties of a selection of bioactive compounds (such as L-theanine and L-tryptophan) for the development of a functional beverage to improve sleep quality; and the effectiveness of traditional sleep promoting beverages (such as milk and chamomile). Overall, the bioactive compounds identified in this review, play essential roles in the synthesis and regulation of important neurotransmitters involved in the sleep-wake cycle. There is also significant potential for their inclusion in a number of functional beverages as the main ingredient on their own or in combination. Future studies should consider dosage; interactions with the beverage matrix, medications and other nutraceuticals; bioavailability during storage and following ingestion; as well as the sensory profile of the developed beverages, among others, when determining their effectiveness in a functional beverage to improve sleep quality.

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The Role of Vitamin C in Two Distinct Physiological States: Physical Activity and Sleep

Cited by 11 publications

References 130 publications

Mediterranean Dietary Patterns Related to Sleep Duration and Sleep-Related Problems among Adolescents: The EHDLA Study

Mediterranean Dietary Patterns Related to Sleep Duration and Sleep-Related Problems among Adolescents: The EHDLA Study

Effect of Carotenoids on Paraoxonase-1 Activity and Gene Expression

Nutraceuticals as Potential Targets for the Development of a Functional Beverage for Improving Sleep Quality

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