The Role of Visual Function in the Patterning of Binocular Visual Connexions

Mj, Keating

doi:10.1093/oxfordjournals.bmb.a071185

Cited by 58 publications

(12 citation statements)

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“…This, however, does not show that the maps are totally independent. For example, an experience-dependent matching has been demonstrated for the intertectal visual map in amphibians (Keating, 1974;Keating and Feldman, 1975). The transplantation of eyes to eyeless salamanders offers a powerful method for testing the possibility of functional interactions between the developing visual and somatosensory systems.…”

Section: Discussionmentioning

confidence: 99%

The transplantation of eyes to genetically eyeless salamanders: visual projections and somatosensory interactions

Harris¹

1982

J. Neurosci.

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Eyes were transplanted from normal axolotls to eyeless mutants, and several anatomical and physiological observations were made on the central visual centers in these animals. Some central projections were bilateral to the optic centers of the thalamus and midbrain, some traveled ipsilaterally to the same centers, and the rest grew down the spinal cord. This is similar to what has been found in eyes transplanted to normal hosts. The type of projection made in eyeless hosts correlated with the site of nerve entry into the CNS as in control hosts. Thus, the transplanted projection did not appear to be influenced by the host's optic nerves and tracts or lack of them. In spite of the transplanted optic fibers' taking abnormal paths, they made normally organized topographic maps on the host tecta. The visual and somatosensory topographic projections to the tectum were found to be in near perfect register normally, but in eyeless mutants to which rotated eyes had been transplanted, they were not. Acetylcholinesterase activity, found in the primary optic neuropil in normal animals, was greatly diminished in eyeless mutants, yet normal mutants with grafted eyes. Finally, transplantation of an eye to an eyeless mutant corrected the abnormally dark pigmentation caused by eyelessness but only in those cases of bilateral central innervation.

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Section: Discussionmentioning

confidence: 99%

The transplantation of eyes to genetically eyeless salamanders: visual projections and somatosensory interactions

Harris¹

1982

J. Neurosci.

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“…Finally, we will restrict ourselves to the data obtained from "adult" animals after metamorphosis has taken place and will therefore not include ontogenetic problems. With respect to the development or regeneration of structure and function in the anuran visual system, the reader is referred to the articles of CRONLy-DILLON (1968), JACOBSON (1969), JACOBSON and HIRSCH (1973), HIRSCH and JACOBSON (1973), GAZE (1974), KEATING (1974).…”

Section: Introductionmentioning

confidence: 99%

Neurophysiology of the Anuran Visual System

Grüsser¹,

Grüsser‐Cornehls²

1976

Frog Neurobiology

240

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“…One important consequence of experience-dependent modifications during early life is that these effects can compensate for developmental alterations in the relative geometry of different sense organs. For example, plasticity of the input from the two eyes onto binocularly driven neurones in the visual cortex (Pettigrew, 1978;Blakemore, 1979) or optic tectum (Keating, 1974) allows adjustments to be made to changes in inter-ocular relationships during growth.…”

Section: Development Of the Map Of Auditory Space In The Superior Colmentioning

confidence: 99%

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1993

Experimental Physiology

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Acoustical basis of the auditory space map 565 Monaural and binaural representations of auditory space 565 Spectral cues provided by the outer ear 567 Visual-auditory integration in the superior colliculus 569 Effects of eye and pinna position on auditory spatial tuning 572 Development of the map of auditory space in the superior colliculus 576 Postnatal maturation of auditory spatial tuning 576 Role of auditory experience in the development of the auditory space map 577 Role of visual experience in the development of the auditory space map 581 Summary 586 References 587 This lecture was given at the Charing Cross and Westminster meeting of the Physiological Society in

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The Role of Visual Function in the Patterning of Binocular Visual Connexions

Cited by 58 publications

References 0 publications

The transplantation of eyes to genetically eyeless salamanders: visual projections and somatosensory interactions

The transplantation of eyes to genetically eyeless salamanders: visual projections and somatosensory interactions

Neurophysiology of the Anuran Visual System

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