The role of viruses in human acute appendicitis: a systematic literature review

Soltani, Saber; Kesheh, Mina Mobini; Siri, Goli; Faramarzi, Samireh; Shahbahrami, Ramin; Didehdar, Mojtaba; Erfani, Yousef; Farahani, Abbas

doi:10.1007/s00384-023-04391-z

Cited by 5 publications

(5 citation statements)

References 75 publications

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“…Unfortunately, this correlation did not remain significant after a Bonferroni correction for multiple testing. Interestingly, several viruses, including Adenovirus, have been previously associated with appendicitis when tested in a patient with appendicitis [34][35][36]. In conclusion, we cannot confirm the role of Adenovirus in appendicitis based upon the results of our study, but we hypothesize that Adenoviruses may potentially play a role in the pathogenesis of simple and complex appendicitis.…”

Section: Is There a Role For Viruses In Simple And Complex Appendicit...contrasting

confidence: 63%

Trends in Simple and Complex Appendicitis in Children and the Potential Correlation to Common Viral Pathogens—A Retrospective Cohort Study between 2010 and 2019 in The Netherlands

The,

van Amstel,

Noordzij

et al. 2023

Children

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The aim of this study was to evaluate the annual, seasonal and monthly trends in children with simple and complex appendicitis and their correlation to common viral pathogens in the Netherlands. A consecutive multicenter retrospective cohort study was performed between 2010 and 2019 including children (<18 years) surgically treated for appendicitis. The primary outcome was the distribution of children with simple and complex appendicitis per year, season and month. Relevant seasonal variation was defined as ≥5%. The secondary outcome was a positive correlation of the number of patients with simple and complex appendicitis to common viral pathogens (data anonymously provided by the Dutch Working Group on Clinical Virology from the Dutch Society for Clinical Microbiology (NVMM)). In total, 896 patients were included: N = 524 (58%) patients with simple and N = 372 (42%) with complex appendicitis. Of the children aged 0–5 years, 81% had complex appendicitis, versus 38% in 6–18 years (p < 0.001). An overall decline was demonstrated for both simple and complex appendicitis between 2010 and 2019. No seasonal variation was found for simple appendicitis. For complex appendicitis, the highest number of patients was found in spring, and lowest in summer (N = 372, spring 28.2 ± 5.1% versus summer 21.0 ± 5.8%, p = 0.011), but the variance was regarded as not relevant (<5% from baseline). A positive correlation was found between complex appendicitis with Adenovirus 40.41 (R = 0.356, 95%CI 0.045–0.604, p = 0.026) and simple appendicitis with Adenovirus NON 40.41 (R = 0.332, 95%CI 0.019–0.586, p = 0.039), but these correlations did not remain significant after a Bonferroni correction (p < 0.003). In conclusion, we found no relevant seasonal variation for simple or complex appendicitis, nor positive correlation with common viral pathogens.

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Section: Is There a Role For Viruses In Simple And Complex Appendicit...contrasting

confidence: 63%

Trends in Simple and Complex Appendicitis in Children and the Potential Correlation to Common Viral Pathogens—A Retrospective Cohort Study between 2010 and 2019 in The Netherlands

The,

van Amstel,

Noordzij

et al. 2023

Children

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“…I very quickly realized that this method was entirely unreliable and seemed to be deemed ‘correct’ simply because it grossly underestimated future demand, thereby ‘confirming’ the political view that England needed fewer hospital beds because the NHS was ‘inefficient’. The abject failure of age-based forecasting to predict future admissions is illustrated in Supplementary Material S2 [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ], where the actual trend in admissions for diseases of the appendix (mostly appendicitis) is compared to the age-based forecast.…”

Section: Introductionmentioning

confidence: 99%

Addressing the Knowledge Deficit in Hospital Bed Planning and Defining an Optimum Region for the Number of Different Types of Hospital Beds in an Effective Health Care System

Jones

2023

IJERPH

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Based upon 30-years of research by the author, a new approach to hospital bed planning and international benchmarking is proposed. The number of hospital beds per 1000 people is commonly used to compare international bed numbers. This method is flawed because it does not consider population age structure or the effect of nearness-to-death on hospital utilization. Deaths are also serving as a proxy for wider bed demand arising from undetected outbreaks of 3000 species of human pathogens. To remedy this problem, a new approach to bed modeling has been developed that plots beds per 1000 deaths against deaths per 1000 population. Lines of equivalence can be drawn on the plot to delineate countries with a higher or lower bed supply. This method is extended to attempt to define the optimum region for bed supply in an effective health care system. England is used as an example of a health system descending into operational chaos due to too few beds and manpower. The former Soviet bloc countries represent a health system overly dependent on hospital beds. Several countries also show evidence of overutilization of hospital beds. The new method is used to define a potential range for bed supply and manpower where the most effective health systems currently reside. The method is applied to total curative beds, medical beds, psychiatric beds, critical care, geriatric care, etc., and can also be used to compare different types of healthcare staff, i.e., nurses, physicians, and surgeons. Issues surrounding the optimum hospital size and the optimum average occupancy will also be discussed. The role of poor policy in the English NHS is used to show how the NHS has been led into a bed crisis. The method is also extended beyond international benchmarking to illustrate how it can be applied at a local or regional level in the process of long-term bed planning. Issues regarding the volatility in hospital admissions are also addressed to explain the need for surge capacity and why an adequate average bed occupancy margin is required for an optimally functioning hospital.

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“…However, this mechanism is not observed in all cases [ 1 ]. It has also been proposed that appendiceal inflammation may be secondary to a tumor, a foreign body or an infection (viral or bacterial) [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Flow cytometric characterization of cecal appendix lymphocyte subpopulations in children: a pilot study

Arredondo Montero,

Torres López,

Hurtado Ilzarbe

et al. 2023

Pediatr Surg Int

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Introduction Scientific literature regarding the characterization of lymphocyte subpopulations of the cecal appendix is sparse, with few precedents limited to immunohistochemical techniques. Methods We conducted a prospective pilot study to characterize lymphocyte subpopulations of the cecal appendix in children. Participants were divided into three groups: (1) patients without histological acute appendiceal inflammation, (2) patients with histological uncomplicated acute appendicitis, and (3) patients with histological complicated acute appendicitis (gangrenous, perforated). A fresh sample of the base of the appendix was taken from all patients and a flow cytometric study was performed. Quantitative variables were compared using Kruskal–Wallis test and Mann–Whitney U test. Results This study included 57 patients divided into Group 1 (n = 5), Group 2 (n = 37), and Group 3 (n = 15). Median values (IQR) of the percentage of B-lymphocytes were 67.8 [66.8–68.1] in group 1, 61.15 [53.74–66.4] in group 2, and 52.1 [33–62.02] in group 3 (p = 0.02). Median values (IQR) of the percentage of NK-lymphocytes were 0.26 [0.2–0.3] in group 1, 0.55 [0.37–0.66] in group 2, and 0.84 [0.35–1.45] in group 3 (p = 0.008). Median values (IQR) of the percentage of T-lymphocytes were 31.9 [31.7–33.1] in group 1, 37.68 [32.15–45.69] in group 2, and 46.9 [37.03–67] in group 3 (p = 0.02). Pair comparisons of groups 2 and 3 also showed significant differences in the percentage of B lymphocytes (p = 0.03) and NK-lymphocytes (p = 0.02). Conclusions Significant differences in lymphocyte subpopulations were identified according to the histologic grade of the cecal appendix. More specifically, a lower percentage of B-lymphocytes and a higher percentage of T- and NK-lymphocytes were observed in cases of acute appendicitis. These findings must be confirmed and their etiopathogenic, diagnostic, and prognostic implications elucidated in future studies with larger sample sizes.

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The role of viruses in human acute appendicitis: a systematic literature review

Cited by 5 publications

References 75 publications

Trends in Simple and Complex Appendicitis in Children and the Potential Correlation to Common Viral Pathogens—A Retrospective Cohort Study between 2010 and 2019 in The Netherlands

Trends in Simple and Complex Appendicitis in Children and the Potential Correlation to Common Viral Pathogens—A Retrospective Cohort Study between 2010 and 2019 in The Netherlands

Addressing the Knowledge Deficit in Hospital Bed Planning and Defining an Optimum Region for the Number of Different Types of Hospital Beds in an Effective Health Care System

Flow cytometric characterization of cecal appendix lymphocyte subpopulations in children: a pilot study

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