The role of viral infection in asthma and bronchitis

Gregg, Ian; Horn, M E; Brain, Elizabeth; Inglis, J.M.; Yealland, S J

doi:10.1016/0041-3879(75)90045-8

Cited by 10 publications

(11 citation statements)

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“…An association between infection by rhinoviruses and acute episodes of bronchitis and asthma has been reported by other workers, both in adults (Eadie et al 1966;Stenhouse 1967;Lambert & Stern 1972;Gregg 1975;Minor et al 1976) and in children (Gregg 1970;Minor et al 1974a, c;Mitchell et al 1978;Horn et al 1979).…”

Section: Discussionmentioning

confidence: 54%

A study of infective and other factors in exacerbations of chronic bronchitis

McHardy

Inglis

Calder

et al. 1980

British Journal of Diseases of the Chest

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Section: Discussionmentioning

confidence: 54%

A study of infective and other factors in exacerbations of chronic bronchitis

McHardy

Inglis

Calder

et al. 1980

British Journal of Diseases of the Chest

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“…In a survey of all forms of acute respiratory illness in children, aged 0-12 years, in a London general practice (Gregg, 1970(Gregg, , 1975Horn et al, 1975), one of our principal aims was to elucidate the role of viral infection in wheezy bronchitis. We have used this term to denote episodes of illness whose salient features are cough and the presence on auscultation of wheeze in addition to crackles.…”

mentioning

confidence: 99%

Respiratory viral infection and wheezy bronchitis in childhood.

Horn¹,

Brain²,

Gregg³

et al. 1979

Thorax

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The role of respiratory viral infection in wheezy bronchitis was studied in 163 children, aged 0-12 years, in a London general practice. Virological investigations were also performed when these same children had acute upper respiratory illness without wheeze. A virus was isolated in 146 (26.4%/,) of 554 episodes of wheezy bronchitis, rhinoviruses accounting for almost half of the isolations. The relative frequency with which individual viruses were isolated in wheezy bronchitis was similar to that in acute upper respiratory illness in 180 other children who had never had wheezy bronchitis. The large number of isolations of rhinoviruses in wheezy bronchitis is probably due to their numerous serotypes and the absence of cross-immunity between them. Our findings have confirmed that infection by respiratory viruses can provoke wheezy bronchitis in certain children, in whom host factors are an important predeterminant. In children with a previous history of wheezy bronchitis infection by rhinoviruses was associated significantly more often with such an episode than with upper respiratory illness. The maturation of protective mechanisms, including the acquisition of specific immunity to a progressively larger number of viruses, could explain the fall in the age-incidence of wheezy bronchitis.

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“…This is no doubt the case in some as isolation was attempted outside the first five days of the illness, but it was only attempted if upper respiratory tract symptoms persisted. The hospital setting may not have been the appropriate place to obtain this evidence and it emphasises the importance of studies carried out in the community (Lambert and Stern, 1972;Gregg, 1975;Horn et al, 1975). Despite this the study does suggest that these symptoms in an adult asthmatic subject do not always indicate viral infection.…”

Section: Discussionmentioning

confidence: 87%

Relationship of bacterial and viral infections to exacerbations of asthma.

Clarke¹

1979

Thorax

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Fifty-one asthmatic patients were followed for up to 18 months. During this time 111 exacerbations of wheeze were recorded. Involvement by pathogenic respiratory bacteria and viruses was looked for directly by culture and indirectly by antibody studies. Proof of infection was found in only 12 (108%) of the i11 exacerbations. Only eight patients provided sputum samples. Potential bacterial pathogens were found in four. Viruses were isolated in four of 27 exacerbation specimens; significant rises in specific viral antibody titres occurred in three. Six patients developed precipitating antibody to respiratory bacteria over the study but only one in relation to an exacerbation. The study therefore indicated that the great majority of exacerbations of asthma in these patients were not due to respiratory tract infection.

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The role of viral infection in asthma and bronchitis

Cited by 10 publications

References 0 publications

A study of infective and other factors in exacerbations of chronic bronchitis

A study of infective and other factors in exacerbations of chronic bronchitis

Respiratory viral infection and wheezy bronchitis in childhood.

Relationship of bacterial and viral infections to exacerbations of asthma.

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