The Role of Vimentin in Human Corneal Fibroblast Spreading and Myofibroblast Transformation
Miguel Miron-Mendoza,
Kara Poole,
Sophie DiCesare
et al.
Abstract:Vimentin has been reported to play diverse roles in cell processes such as spreading, migration, and cell-matrix adhesion. Here, we use vimentin knock out cells (Vim KO) to assess how vimentin impacts cell spreading, morphology, and myofibroblast transformation of human corneal fibro-blasts. Overall, loss of vimentin did not significantly impact corneal fibroblast spreading, as indicated by Vim KO morphology and mechanical activity (traction force). However, we found that Vim KO cells had reduced elongation in… Show more
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