The Role of Video-EEG Monitoring in Lesch-Nyhan Syndrome
Eugenia ROZA,
Anca Denisa BALOI,
Vasilica PLAIASU
et al.
Abstract:Introduction: Lesch-Nyhan syndrome (LNS) is a rare genetic disease secondary to a HPRT1 mutation on chromosome X. It is characterized by dystonia, developmental delay, hyperuricemia and self-harming behaviours. The HPRT enzyme is implicated in the purine salvage pathway. The deficiency of HPRT results in accumulation of uric acid. There have been some cases associated with epilepsy, but it still remains a rare occurrence in LNS patients.Case presentation: We describe the case of a 20-month-old male patient wit… Show more
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