2013
DOI: 10.1158/1541-7786.mcr-12-0461
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Abstract: Versican is highly expressed during the early stages of tissue development and its expression is elevated during wound repair and tumor growth. There is little literature on the potential role of breast cancer stem cells on the cellularextracellular matrix interactions involving versican. An anti-versican short hairpin RNA (shRNA) was used to observe the effect of reduction of versican on breast cancer self-renewal. A versican G3 construct was exogenously expressed in breast cancer cell lines. Colony formation… Show more

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Cited by 43 publications
(36 citation statements)
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References 47 publications
(60 reference statements)
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“…G3-induced EGFR/AKT/GSK-3β (S9P) signaling in breast cancer cells also enhances breast cancer cell self-renewal both in vitro and in vivo . In this model, versican is highly expressed in breast cancer progenitor cells and confers resistance to chemotherapeutic drugs [56]. It is obvious that accumulated versican in ECM is capable of stimulating several cell types through activation of various signaling pathways promoting the secretion of inflammatory mediators that augment tumor growth and metastasis.…”
Section: Versican: a Tumor Stroma-associated Proteoglycan In Breasmentioning
confidence: 99%
“…G3-induced EGFR/AKT/GSK-3β (S9P) signaling in breast cancer cells also enhances breast cancer cell self-renewal both in vitro and in vivo . In this model, versican is highly expressed in breast cancer progenitor cells and confers resistance to chemotherapeutic drugs [56]. It is obvious that accumulated versican in ECM is capable of stimulating several cell types through activation of various signaling pathways promoting the secretion of inflammatory mediators that augment tumor growth and metastasis.…”
Section: Versican: a Tumor Stroma-associated Proteoglycan In Breasmentioning
confidence: 99%
“…This proteoglycan interacts with multiple ECM and cell surface components, promoting cell proliferation, cell motility, and metastasis (301,310,382). Intriguingly, in breast cancer, versican has been associated with chemotherapy resistance related to EGFR hypersignaling and enhanced cancer cell self-renewal (78,79). Moreover, versican synthesis appears to be upregulated by TAFs in the ovarian cancer stroma (407) where TGF-␤ signaling triggers versican expression, and together they contribute to promote ovarian cancer aggressiveness (407).…”
Section: Proteoglycansmentioning
confidence: 99%
“…The stained cells were analyzed by flow cytometry using a dual-wavelength analysis (blue, 424-444 nm; red, 675 nm) after excitation with 350-nm UV light. Side population cell analysis was performed as previously described (Du et al, 2013b;Fang et al, 2013).…”
Section: Side Population Analysismentioning
confidence: 99%