The role of vasopressin in the impaired water excretion of myxedema

Skowsky, W. Ronald; Kikuchi, Thomas A.

doi:10.1016/0002-9343(78)90581-8

Cited by 187 publications

(86 citation statements)

References 39 publications

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“…The alterations in body weight associated with hypothyroidism may reflect both the accumulation of body fat (83,101), due to decreased REE and reduced physical activity, and the increased water content of the body (102), consequent to a reduced capacity of excreting free water (103). Hypothyroid subjects also have increased amounts of glycosaminoglycans that are responsible for the greater water-binding capacity, a condition that results in the typical 'myxedema' of hypothyroidism (102).…”

Section: Hypothyroidism and Body Weightmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: The crosstalk between thyroid gland and adipose tissue: signal integration in health and disease

Santini

Marzullo

Rotondi

et al. 2014

European Journal of Endocrinology

203

185

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Obesity and thyroid diseases are common disorders in the general population and they frequently occur in single individuals. Alongside a chance association, a direct relationship between 'thyroid and obesity' has been hypothesized. Thyroid hormone is an important determinant of energy expenditure and contributes to appetite regulation, while hormones and cytokines from the adipose tissue act on the CNS to inform on the quantity of energy stores. A continuous interaction between the thyroid hormone and regulatory mechanisms localized in adipose tissue and brain is important for human body weight control and maintenance of optimal energy balance. Whether obesity has a pathogenic role in thyroid disease remains largely a matter of investigation. This review highlights the complexity in the identification of thyroid hormone deficiency in obese patients. Regardless of the importance of treating subclinical and overt hypothyroidism, at present there is no evidence to recommend pharmacological correction of the isolated hyperthyrotropinemia often encountered in obese patients. While thyroid hormones are not indicated as anti-obesity drugs, preclinical studies suggest that thyromimetic drugs, by targeting selected receptors, might be useful in the treatment of obesity and dyslipidemia.

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Section: Hypothyroidism and Body Weightmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: The crosstalk between thyroid gland and adipose tissue: signal integration in health and disease

Santini

Marzullo

Rotondi

et al. 2014

European Journal of Endocrinology

203

185

View full text Add to dashboard Cite

show abstract

“…In addition, our results suggested the integrity of the PRA-aldosterone axis. Most studies detect a decrease in the elimination of a water loading in hypothyroid patients, (DeRubertis et al 1971, Skowsky & Kikuchi 1978, Laczi et al 1987, Iwasaki et al 1990, Ota et al 1994) and a lower plasma osmolality than euthyroid individuals (Laczi et al 1987, Iwasaki et al 1990, Barna et al 1994, Ota et al 1994.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have found high plasma AVP and postulate the role of this hormone in the development of hyponatremia of hypothyroidism (Skowsky & Kikuchi 1978, Laczi et al 1987. Others have found that plasma AVP is normal or even suppressed (Iwasaki et al 1990, Vargas et al 1991, Arnaout et al 1992, Ota et al 1994.…”

Section: Discussionmentioning

confidence: 99%

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Water metabolism disturbances at different stages of primary thyroid failure

Villabona¹,

Rosel²,

Navarro³

et al. 2001

Journal of Endocrinology

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The aim of the present study was to study salt and water metabolism in thyroid deficiency.We performed an oral water loading test (OWL) and a hypertonic 5% saline infusion test (HSI) in 16 patients with overt primary hypothyroidism before replacement treatment (PRE group) and after, in eight patients with subclinical hypothyroidism (SUB group) and in 16 normal individuals (CG group).In the PRE group, a lower free water clearance was detected in the OWL (P<0·022), with lower plasma osmolality (OWL: P<0·005; HSI: P<0·001) and arginine vasopressin (AVP) (OWL: P<0·001; HSI: P<0·001) than the CG group, across both tests; they normalized with the replacement treatment. The same plasma abnormalities were detected in the SUB group with the HSI. Although the AVP and thirst thresholds did not differ between the groups, the lag between them was lower in the PRE (4·1 3·2 mOsm/kg) and SUB group (2·6 2·1 mOsm/ kg) than in the CG group (13·3 9·2 mOsm/kg) (P<0·05). There were no differences in atrial natriuretic hormone (ANH), plasma renin activity (PRA) and plasma aldosterone among the groups.These results indicate that plasma hypo-osmolality and low levels of AVP are present in primary hypothyroidism, and indeed are already present in the subclinical phase of the disease. An overlap between the thresholds of thirst and AVP seem to play a role in these abnormalities, but ANH, PRA and plasma aldosterone do not appear to contribute.

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“…Whenthere is an increased ADHrelease, associated with the presence of hypervolemic hyponatremia with impaired urine dilution, it is well knownthat the pathological state is coined as the syndrome of inappropriate secretion of ADH(SIADH). Skowsky and Kikuchi (5) showed that plasma ADHwas elevated and was not sufficiently suppressed in response to decreases in plasma osmolality in hypothyroidism. Laczi et al (6) reported that patients with severe hypothyroidism had high plasma ADH and decreases in osmotic threshold ADHrelease.…”

mentioning

confidence: 99%

Potential Mechanisms of Hypothyroidism-induced Hyponatremia

Kimura

2000

Intern. Med.

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The role of vasopressin in the impaired water excretion of myxedema

Cited by 187 publications

References 39 publications

MECHANISMS IN ENDOCRINOLOGY: The crosstalk between thyroid gland and adipose tissue: signal integration in health and disease

MECHANISMS IN ENDOCRINOLOGY: The crosstalk between thyroid gland and adipose tissue: signal integration in health and disease

Water metabolism disturbances at different stages of primary thyroid failure

Potential Mechanisms of Hypothyroidism-induced Hyponatremia

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