The Role of Vasoactive Intestinal Polypeptide as a Neurotransmitter in Canine Penile Erection: A Combined in Vivo and Immunohistochemical Study

Juenemann, Klaus‐Peter; Lue, Tom F.; Luo, Jian-An; Jadallah, Sami A.; Nunes, Lora; Tanagho, Emil A.

doi:10.1016/s0022-5347(17)43406-9

Cited by 71 publications

(25 citation statements)

References 22 publications

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“…In animal studies, intracavernosal VIP induced tumescence and partial erection, which was primarily due to decreased penile venous out¯ow and to a minor extent, increased arterial in¯ow. 30 Clinical results of self-injection therapy with marketed vasoactive drugs Papaverine Papaverine is extremely stable in solution and loses only 10% of its potency over a 4 y period. Commercial papaverine solutions have a low pH between 3 31 Papaverine is extensively metabolised in the liver.…”

Section: Vasoactive Intestinal Polypeptidementioning

confidence: 99%

Current perspectives on intracavernosal pharmacotherapy for erectile dysfunction

Porst¹

2000

Int J Impot Res

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Thirty percent of males af¯icted with erectile dysfunction (ED) do not respond to oral drugs, another 15% reveal contraindications to currently available therapy, and a subset of patients actually prefer injection therapy due to its predictable short time-to-onset of erection and reliable rigidity compared to oral drugs. This paper provides both a historical and current perspective on intracavernosal therapy and reviews the popular injectable therapeutic agents that are currently used for the treatment of ED. Emphasis is placed on the ef®cacy, mechanism of action and side effect pro®les of approved and experimental injectable pharmacotherapy for ED.

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Section: Vasoactive Intestinal Polypeptidementioning

confidence: 99%

Current perspectives on intracavernosal pharmacotherapy for erectile dysfunction

Porst¹

2000

Int J Impot Res

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“…10 The results of some in vivo studies demonstrated that VIP can induce an increase in ICP in various species. 11 Jü nemann et al concluded that the physiological dose of VIP cannot induce a full erection in dogs and that the major VIP induced hemodynamic change during penile erection is more likely to be found in the venous drainage system. 11 This conclusion became evident after analysing the venous studies of the same group and the data revealed that venous outflow restriction took place after minimal doses of i.c.…”

Section: Discussionmentioning

confidence: 99%

“…While the blockade of NOS activity by an infusion of arginine analogues can completely inhibit the rise in ICP in response to nerve stimulation, the administration of VIP antibodies severely compromises the maintenance of erection. 11 On the other hand, the initial engorgement of the penis during nerve stimulation could not be prevented by the administration of VIP antibodies. Conversely, the administration of SIN-1, S-nitroso-N-acetylpenicillamine or sodium nitroprussidespontaneously NO liberating chemical compounds in in vivo models and chemical trials either caused inadequate erectile responses or very high doses of these compounds were necessary for the induction of erectile responses.…”

Section: Discussionmentioning

confidence: 99%

“…22 -25 Inadequate erectile responses only were achieved with VIP. 11,12,26 In addition, reports have been made on the coactivation of NO and VIP in other organs. 27,28 These findings have led to the suggestion that NO and VIP may serve complementary roles during various phases of erection.…”

Section: Discussionmentioning

confidence: 99%

“…This fact and the abovementioned findings imply that the primary role of VIP during erection could be to effect the duration of venous restriction by maintaining the relaxant effects of NO in the smooth muscle cells. 9,11,26 The…”

Section: Discussionmentioning

confidence: 99%

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Intracavernous administration of SIN-1+VIP in an in vivo rabbit model for erectile function

et al. 2002

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In accordance with the data reporting the identification of nitric oxide synthase (NOS) and vasoactive intestinal polypeptide (VIP) positive nerve fibres in the trabecular meshwork of the corpus cavernosum, we suggest that nitric oxide (NO) and VIP may serve complementary physiological roles in penile erection. Therefore SIN-1 and VIP were administered alone and in combination in an in vivo rabbit model. All rabbits revealed basal pressure values of 5 -8 cm H 2 O intracavernously. In the rabbits intracavernously (i.c.) injected with SIN-1 alone and VIP alone, no adequate erectile responses were observed. Whereas, in the group intracavernously injected with the combination of SIN-1 þ VIP, erectile responses with mean maximal intracavernous pressure (max. ICP) 52.8 ( AE 13.2) cm H 2 O were noted. These pressure elevations do not statistically diverge (P > 0.05) than the ones obtained in the control group administered i.c. injections of the combination of papaverine=phentolamine (mean max. ICP 51 ( AE 14.73) cm H 2 O). Referring to our results, we conclude that the combined use of SIN-1 þ VIP could play an important role in the physiological treatment of erectile dysfunction.

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Involvement of Vasoactive Intestinal Peptide (VIP) as a Humoral Mediator of Penile Erectile Function in the Dog

AOKI,

MATSUZAKA,

YEH

et al. 1994

Journal of Andrology

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The effects of intracorporeal infusion of anti‐vasoactive intestinal peptide (anti‐VIP) antisera on electrically induced penile erection were studied in 18 male mongrel dogs. Electrical pulse stimulation (4 V, 4 milliseconds, 40 Hz) of the pelvic splanchnic nerve consistently produced penile erection (“electroerection”). Using this erection model, effects of anti‐VIP serum were evaluated with regard to the peak intracorporeal pressure during electroerection. Pretreatment of the animals with repetitive intracorporeal infusion of anti‐VIP rabbit serum completely abolished the electroerection in nine dogs, partially suppressed it (P < 0.01) in five, and was without effects in four. In contrast, control treatment of the same 18 dogs with normal rabbit serum was totally ineffective. In six dogs in which anti‐VIP serum failed to produce a complete suppression of electroerection, 0.5 mg atropine sulfate was additionally given i.v. All six dogs exhibited significant (P < 0.01) suppression of the peak intracorporeal pressure after atropine. However atropine alone did not affect the intracorporeal pressure to any significant degree. To five of these six dogs with positive response to the combination treatment with anti‐VIP serum and atropine, prazosin HCI was added i.v. It was found that prazosin HCI reversed the attenuation of electroerection produced by combined anti‐VIP serum and atropine. Prazosin did not affect the intracorporeal pressure when administered following anti‐VIP serum. These results suggest that VIP plays a role as a humoral mediator involved in penile erection and that there is a synergistic interaction between VIP and acetylcholine. Also it appears that the effect of acetylcholine but not that of VIP is mediated by the alpha‐1 adrenergic mechanism.

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The Role of Vasoactive Intestinal Polypeptide as a Neurotransmitter in Canine Penile Erection: A Combined in Vivo and Immunohistochemical Study

Cited by 71 publications

References 22 publications

Current perspectives on intracavernosal pharmacotherapy for erectile dysfunction

Current perspectives on intracavernosal pharmacotherapy for erectile dysfunction

Intracavernous administration of SIN-1+VIP in an in vivo rabbit model for erectile function

Involvement of Vasoactive Intestinal Peptide (VIP) as a Humoral Mediator of Penile Erectile Function in the Dog

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