1987
DOI: 10.1016/s0022-5347(17)43406-9
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The Role of Vasoactive Intestinal Polypeptide as a Neurotransmitter in Canine Penile Erection: A Combined in Vivo and Immunohistochemical Study

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Cited by 71 publications
(25 citation statements)
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“…In animal studies, intracavernosal VIP induced tumescence and partial erection, which was primarily due to decreased penile venous out¯ow and to a minor extent, increased arterial in¯ow. 30 Clinical results of self-injection therapy with marketed vasoactive drugs Papaverine Papaverine is extremely stable in solution and loses only 10% of its potency over a 4 y period. Commercial papaverine solutions have a low pH between 3 31 Papaverine is extensively metabolised in the liver.…”
Section: Vasoactive Intestinal Polypeptidementioning
confidence: 99%
“…In animal studies, intracavernosal VIP induced tumescence and partial erection, which was primarily due to decreased penile venous out¯ow and to a minor extent, increased arterial in¯ow. 30 Clinical results of self-injection therapy with marketed vasoactive drugs Papaverine Papaverine is extremely stable in solution and loses only 10% of its potency over a 4 y period. Commercial papaverine solutions have a low pH between 3 31 Papaverine is extensively metabolised in the liver.…”
Section: Vasoactive Intestinal Polypeptidementioning
confidence: 99%
“…10 The results of some in vivo studies demonstrated that VIP can induce an increase in ICP in various species. 11 Jü nemann et al concluded that the physiological dose of VIP cannot induce a full erection in dogs and that the major VIP induced hemodynamic change during penile erection is more likely to be found in the venous drainage system. 11 This conclusion became evident after analysing the venous studies of the same group and the data revealed that venous outflow restriction took place after minimal doses of i.c.…”
Section: Discussionmentioning
confidence: 99%
“…While the blockade of NOS activity by an infusion of arginine analogues can completely inhibit the rise in ICP in response to nerve stimulation, the administration of VIP antibodies severely compromises the maintenance of erection. 11 On the other hand, the initial engorgement of the penis during nerve stimulation could not be prevented by the administration of VIP antibodies. Conversely, the administration of SIN-1, S-nitroso-N-acetylpenicillamine or sodium nitroprussidespontaneously NO liberating chemical compounds in in vivo models and chemical trials either caused inadequate erectile responses or very high doses of these compounds were necessary for the induction of erectile responses.…”
Section: Discussionmentioning
confidence: 99%
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