The role of vascular endothelial growth factor in the development of papillary thyroid carcinoma in patients with lymphocytic thyroiditis

Gülçelik, Neşe Ersöz; Akın, Şafak; Aydín, Kadriye; Mericoz, Cisel Aydin; Tezel, Yeşim Gaye Güler; Usman, Aydan

doi:10.23736/s2724-6507.22.03663-6

Cited by 14 publications

(14 citation statements)

References 35 publications

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“…Whether CLT affects the aggressiveness of PTC remains controversial. Some have suggested that CLT is a protective factor for thyroid cancer, while others put forward the opposite view 11‐13 . In our study, the incidence of PTC coexistent with CLT was 32.9%, which is consistent with previous studies 10 .…”

Section: Discussionsupporting

confidence: 92%

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Nomograms for Prediction of High‐Volume Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients

Feng

et al. 2023

Otolaryngol.--head neck surg.

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Objective. The coexistence rate between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is quite high. Whether CLT influences metastatic lymph nodes remains uncertain. High-volume lymph node metastasis is recommended as an unfavorable pathological feature. We aimed to investigate risk factors for high-volume central lymph node metastasis (CLNM) and lateral lymph node metastasis (LLNM) in PTC patients.Study Design. Retrospective cohort study.Setting. Changzhou First People's Hospital.Methods. Clinicopathological characteristics of 1094 PTC patients who underwent surgery in our center from January 2019 to November 2021 were analyzed.Results. The number of metastatic lymph nodes in the central compartment and lateral compartment were lower in the CLT group. We demonstrated that age, BRAF V600E, shape, and the number of foci were risk factors for high-volume CLNM in patients with CLT. For patients without CLT, sex, age, tumor size, number of foci, and margin were risk factors for high-volume CLNM. Tumor size, number of foci, location, and CLNM were all risk factors for high-volume LLNM in patients with or without CLT. Body mass index was only associated with highvolume LLNM in CLT patients. All the above factors were incorporated into nomograms, which showed perfect discriminative ability. Conclusion.Separate predictive systems should be used for CLT and non-CLT patients for a more accurate clinical assessment of lymph node status. Our nomograms of predicting high-volume CLNM and LLNM could facilitate risk-stratified management of PTC recurrence and treatment decisions.

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Section: Discussionsupporting

confidence: 92%

“…When the two diseases coexist, whether CLT will affect the aggressiveness of PTC is an interesting topic. Some consider that CLT has no protective effect on PTC, 11 while others argue that PTC coexistent with CLT has a lower rate of LNM and better prognosis 12,13 …”

mentioning

confidence: 99%

Nomograms for Prediction of High‐Volume Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients

Feng

et al. 2023

Otolaryngol.--head neck surg.

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“…Adiponectin is a cytokine involved in mitochondrial biogenesis through the activation of PGC-1α-AMPK kinase axis (40). Higher levels of this protein are associated with increased resting energy metabolism (40,41), whereas it inversely correlates with obesity (42). We have previously reported an increase in adiponectin after 8 wk of TRE (16); in the present study, we confirmed that this adaptation persists during long-term TRE.…”

Section: Discussionsupporting

confidence: 85%

“…The adipolysis observed in the TRE group may have been stimulated by adiponectin. Adiponectin is a cytokine involved in mitochondrial biogenesis through the activation of PGC-1α-AMPK kinase axis (40). Higher levels of this protein are associated with increased resting energy metabolism (40,41), whereas it inversely correlates with obesity (42).…”

Section: Discussionmentioning

confidence: 99%

Twelve Months of Time-restricted Eating and Resistance Training Improves Inflammatory Markers and Cardiometabolic Risk Factors

Moro

Tinsley

Pacelli

et al. 2021

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Obesity, especially abdominal obesity, is associated with metabolic syndrome and cardiovascular diseases, and it is also an independent risk factor for death [10]. Existing studies have shown that visceral adipose tissue is associated with higher production of inflammatory cytokines; however, the aging process changes the function, possibilities of proliferation, and size and number of adipocytes, which leads to changes in the secretion and synthesis of adipocytokines [11,12]. The development of imaging techniques such as computed tomography and magnetic resonance imaging has enabled remarkable progress to be made in the assessment of adipose tissue distribution [13].…”

Section: Discussionmentioning

confidence: 99%

Association between lung opacities and visceral fat in COVID-19 patients

Sosna¹,

Młynarska²,

Stasiów³

et al. 2023

Pol J Radiol

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Purpose:To assess the relationship between the amount of the epigastric visceral fat area and the severity of pneumonia in the course of COVID-19 using chest computed tomography (CT) examinations.Material and methods: 177 patients (54 female), with COVID-19 infection were included. A routine chest CT was performed to assess the severity of pneumonia. The affected lung tissue as well as semi-quantitative scales such as the Chest CT Score and Total Opacity Score were calculated using SyngoVia VB30A CT Pneumonia Analysis software. The epigastric region area of visceral fat (L1) was also determined. Results:The mean value of the visceral adipose tissue area was 196.23 ± 101.36 cm 2 . The area of adipose tissue significantly correlated with the percentage of the affected lung tissue (r = 0.1476; p = 0.050), the Chest CT Score (r = 0.2086; p = 0.005), and the Total Opacity Score (r = 0.1744; p = 0.200). The mean area of adipose tissue in the age group ≥ 65 years was 216.13 ± 105.19 cm 2 , while in the group < 65 years, it was 169.18 ± 89.69 cm 2 . This difference was statistically significant (p = 0.002). Conclusions:The study showed a relationship between the area of visceral adipose tissue and the degree of lung inflammation in COVID-19 disease in patients under 65 years of age.

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The role of vascular endothelial growth factor in the development of papillary thyroid carcinoma in patients with lymphocytic thyroiditis

Cited by 14 publications

References 35 publications

Nomograms for Prediction of High‐Volume Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients

Nomograms for Prediction of High‐Volume Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients

Twelve Months of Time-restricted Eating and Resistance Training Improves Inflammatory Markers and Cardiometabolic Risk Factors

Association between lung opacities and visceral fat in COVID-19 patients

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