The role of variants from the innate immune system genes in tuberculosis and skin test response in a Native American population

Lindenau, Juliana Dal-Ri; Salzano, Francisco M.; Hurtado, Ana; Hill, Kim; Hutz, Mara H.

doi:10.1016/j.humimm.2016.06.017

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2017

2018

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CR1 also includes the Knops blood group antigens 33 . Although sample sizes were relatively small, researchers have reported association between a subset of the Knops blood group genotypes and resistance to TB in Mali and in the Aché people of Brazil 34 , 35…”

Section: Discussionmentioning

confidence: 99%

Blood transcriptomic markers of Mycobacterium tuberculosis load in sputum

Dupnik

Bean

Lee

et al. 2018

int j tuberc lung dis

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Blood transcriptomic markers of Mycobacterium tuberculosis load in sputum

Dupnik

Bean

Lee

et al. 2018

int j tuberc lung dis

View full text Add to dashboard Cite

show abstract

Genomics of Human Pulmonary Tuberculosis: from Genes to Pathways

et al. 2017

View full text Add to dashboard Cite

Purpose of review Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a major public health threat globally. Several lines of evidence support a role for host genetic factors in resistance/susceptibility to TB disease and MTB infection. However, results across candidate gene and genome-wide association studies (GWAS) are largely inconsistent, so a cohesive genetic model underlying TB risk has not emerged. Recent Findings Despite the difficulties in identifying consistent genetic associations, genetic studies of TB and MTB infection have revealed a few well-documented loci. These well validated genes are presented in this review, but there remains a large gap in how these genes translate into better understanding of TB. To address this, we present a pathway based extension of standard association analyses, seeding the results with the best validated genes from candidate gene and GWAS studies. Summary Several pathways were significantly enriched using pathway analyses that may help to explain population patterns of TB risk. In conclusion, we advocate for novel approaches to the study of host genetic analysis of TB that extend traditional association approaches.

show abstract

The role of variants from the innate immune system genes in tuberculosis and skin test response in a Native American population

Cited by 2 publications

References 23 publications

Blood transcriptomic markers of Mycobacterium tuberculosis load in sputum

Blood transcriptomic markers of Mycobacterium tuberculosis load in sputum

Genomics of Human Pulmonary Tuberculosis: from Genes to Pathways

Contact Info

Product

Resources

About