The role of vanadium in biology

Abstract

Vanadium is special in at least two respects: on the one hand, the tetrahedral anion vanadate(v) is similar to the phosphate anion; vanadate can thus interact with various physiological substrates that are otherwise functionalized by phosphate. On the other hand, the transition metal vanadium can easily expand its sphere beyond tetrahedral coordination, and switch between the oxidation states +v, +iv and +iii in a physiological environment. The similarity between vanadate and phosphate may account for the antidiabetic potential of vanadium compounds with carrier ligands such as maltolate and picolinate, and also for vanadium's mediation in cardiovascular and neuronal defects. Other potential medicinal applications of more complex vanadium coordination compounds, for example in the treatment of parasitic tropical diseases, may also be rooted in the specific properties of the ligand sphere. The ease of the change in the oxidation state of vanadium is employed by prokarya (bacteria and cyanobacteria) as well as by eukarya (algae and fungi) in respiratory and enzymatic functions. Macroalgae (seaweeds), fungi, lichens and Streptomyces bacteria have available haloperoxidases, and hence enzymes that enable the 2-electron oxidation of halide X(-) with peroxide, catalyzed by a Lewis-acidic V(V) center. The X(+) species thus formed can be employed to oxidatively halogenate organic substrates, a fact with implications also for the chemical processes in the atmosphere. Vanadium-dependent nitrogenases in bacteria (Azotobacter) and cyanobacteria (Anabaena) convert N2 + H(+) to NH4(+) + H2, but are also receptive for alternative substrates such as CO and C2H2. Among the enigmas to be solved with respect to the utilization of vanadium in nature is the accumulation of V(III) by some sea squirts and fan worms, as well as the purport of the nonoxido V(IV) compound amavadin in the fly agaric.

GC-MS and Heavy Metal Analysis of GASCA D Herbal Formulation

“…At ambient conditions, the daily oral intake of vanadium via potable water and food varies between 10 μg and 2 mg. This is clearly beyond the no-effect level of 10 mg vanadium per day and per kg body mass [19]. Vanadium compounds lower blood glucose levels in animals and in clinical trials.…”

A Spectroscopy Approach for the Study of the Interaction of Oxovanadium(IV)-Salen Complexes with Proteins

“…Vanadium(IV) often takes the form of the vanadyl cation (VO 2+ ), and as such can interact with proteins at cationic binding sites similar to divalent calcium, zinc or manganese [45]. Both V IV and V V also form a variety of coordination complexes that may interact with enzymes [46].…”

A novel oxidovanadium(V) compound with an isonicotinohydrazide ligand. A combined experimental and theoretical study and cytotoxity against K562 cells

“…In addition to the widely known therapeutic properties of oxidovanadium(V) compounds, such as their insulin-mimetic activity, there is a growing interest in vanadium compounds as potential therapeutic agents for the treatment of cancer [15][16][17]. A complex of this metal with an o-HVa-derived Schiff base ligand has been determined to bind to CT-DNA in a nonclassical intercalative mode and to possess a strong affinity with the BSA protein, inducing conformational changes [18].…”