The Role of Val66Met Single Nucleotide Polymorphism in Brain-Derived Neurotropic Factor Gene in Prediction of Adverse Outcomes After ST-segment Elevation Myocardial Infarction

Petyunina, O. V.; Kopytsya, M. P.; Berezin, Alexander Е.; Skrynnyk, Olga V

doi:10.4103/hm.hm_40_19

Cited by 2 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, several NT polymorphisms, including BDNF rs6265 (Val66Met) [ 179 , 180 , 181 , 182 , 183 ], NGF rs11102930 [ 184 ] and rs78701042 [ 185 ], have been associated to increased risk of ACS and adverse outcome.…”

Section: Adipokinesmentioning

confidence: 99%

Depression and Cardiovascular Disease: The Viewpoint of Platelets

Amadio

Zara

Sandrini

et al. 2020

IJMS

View full text Add to dashboard Cite

Depression is a major cause of morbidity and low quality of life among patients with cardiovascular disease (CVD), and it is now considered as an independent risk factor for major adverse cardiovascular events. Increasing evidence indicates not only that depression worsens the prognosis of cardiac events, but also that a cross-vulnerability between the two conditions occurs. Among the several mechanisms proposed to explain this interplay, platelet activation is the more attractive, seeing platelets as potential mirror of the brain function. In this review, we dissected the mechanisms linking depression and CVD highlighting the critical role of platelet behavior during depression as trigger of cardiovascular complication. In particular, we will discuss the relationship between depression and molecules involved in the CVD (e.g., catecholamines, adipokines, lipids, reactive oxygen species, and chemokines), emphasizing their impact on platelet activation and related mechanisms.

show abstract

Section: Adipokinesmentioning

confidence: 99%

Depression and Cardiovascular Disease: The Viewpoint of Platelets

Amadio

Zara

Sandrini

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

Myokines and Heart Failure: Challenging Role in Adverse Cardiac Remodeling, Myopathy, and Clinical Outcomes

Berezin

Lichtenauer

2021

Disease Markers

View full text Add to dashboard Cite

Heart failure (HF) is a global medical problem that characterizes poor prognosis and high economic burden for the health system and family of the HF patients. Although modern treatment approaches have significantly decreased a risk of the occurrence of HF among patients having predominant coronary artery disease, hypertension, and myocarditis, the mortality of known HF continues to be unacceptably high. One of the most important symptoms of HF that negatively influences tolerance to physical exercise, well-being, social adaptation, and quality of life is deep fatigue due to HF-related myopathy. Myopathy in HF is associated with weakness of the skeletal muscles, loss of myofibers, and the development of fibrosis due to microvascular inflammation, metabolic disorders, and mitochondrial dysfunction. The pivotal role in the regulation of myocardial and skeletal muscle rejuvenation, attenuation of muscle metabolic homeostasis, and protection against ischemia injury and apoptosis belongs to myokines. Myokines are defined as a wide spectrum of active molecules that are directly synthesized and released by both cardiac and skeletal muscle myocytes and regulate energy homeostasis in autocrine/paracrine manner. In addition, myokines have a large spectrum of pleiotropic capabilities that are involved in the pathogenesis of HF including cardiac remodeling, muscle atrophy, and cardiac cachexia. The aim of the narrative review is to summarize the knowledge with respect to the role of myokines in adverse cardiac remodeling, myopathy, and clinical outcomes among HF patients. Some myokines, such as myostatin, irisin, brain-derived neurotrophic factor, interleukin-15, fibroblast growth factor-21, and growth differential factor-11, being engaged in the regulation of the pathogenesis of HF-related myopathy, can be detected in peripheral blood, and the evaluation of their circulating levels can provide new insights to the course of HF and stratify patients at higher risk of poor outcomes prior to sarcopenic stage.

show abstract

The Role of Val66Met Single Nucleotide Polymorphism in Brain-Derived Neurotropic Factor Gene in Prediction of Adverse Outcomes After ST-segment Elevation Myocardial Infarction

Cited by 2 publications

References 29 publications

Depression and Cardiovascular Disease: The Viewpoint of Platelets

Depression and Cardiovascular Disease: The Viewpoint of Platelets

Myokines and Heart Failure: Challenging Role in Adverse Cardiac Remodeling, Myopathy, and Clinical Outcomes

Contact Info

Product

Resources

About