The role of vaccines in combating antimicrobial resistance (AMR) bacteria

Alghamdi, Saad

doi:10.1016/j.sjbs.2021.08.054

Cited by 25 publications

(15 citation statements)

References 81 publications

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“…To address the declining susceptibility of strains to antibiotics, researchers have proposed alternative therapies, such as traditional herbal medicines, probiotics, vaccines, immunoglobulins, and bacteriophages. These therapies can help reduce selection pressure and minimize resistance to classical antibiotics [2][3][4][5][6]. Traditional herbal medicines have been used for thousands of years to treat bacterial infections, with Artemisia species in particular excelling in traditional antimicrobial herbal medicine [7,8].…”

Section: Introductionmentioning

confidence: 99%

New Evidence for Artemisia absinthium as an Alternative to Classical Antibiotics: Chemical Analysis of Phenolic Compounds, Screening for Antimicrobial Activity

Liu

Jin

et al. 2023

IJMS

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Artemisia absinthium, an important herb of the Artemisia genus, was evaluated in this study for its potential as an alternative to classical antibiotics. The antimicrobial activity of methanol extracts of A. absinthium (MEAA) was evaluated using the broth microdilution method, revealing that A. absinthium exhibited broad-spectrum antibacterial and antifungal activity. Ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometry (UPLC-Q-TOF-MS) was used to analyze the chemical profile of the MEAA, with a focus on flavonoids, quinic acids, and glucaric acids. A total of 90 compounds were identified, 69 of which were described for the first time in A. absinthium. Additionally, a new class of caffeoyl methyl glucaric acids was identified. The main active compounds were quantified and screened for antimicrobial activity. A. absinthium was found to be rich in quinic acids and flavonoids. The screening for antimicrobial activity also revealed that salicylic acid, caffeic acid, casticin, and 3,4-dicaffeoylquinic acid had varying degrees of antimicrobial activity. The acute toxicity of MEAA was examined following OECD guidelines. The administration of 5000 mg/kg bw of MEAA did not result in mortality in male and female mice. Furthermore, there were no observed effects on the visceral organs or general behavior of the mice, demonstrating the good safety of MEAA. This study provides new evidence for the use of A. absinthium as an alternative to classical antibiotics in addressing the problem of bacterial resistance.

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Section: Introductionmentioning

confidence: 99%

New Evidence for Artemisia absinthium as an Alternative to Classical Antibiotics: Chemical Analysis of Phenolic Compounds, Screening for Antimicrobial Activity

Liu

Jin

et al. 2023

IJMS

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“…This can cause a wide range of infections in immunocompromised patients, especially those in intensive care units (ICUs) and neonatal intensive care units (NICU), including respiratory, blood, skin, urinary, and ocular infections with a high incidence of contact lens-related keratitis, catheter-related infections, sepsis, and meningitis. Serratia species is at the top of the World Health Organization (WHO) priority list of MDR bacteria (Carmeli et al, 2018 ) that pose a severe threat to human health globally (Bloom et al, 2018 ; Jansen and Anderson, 2018 ; Alghamdi, 2021 ). According to recent studies, the number of S. marcescens multidrug-resistant strains has increased globally.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the whole proteome to design a novel mRNA-based vaccine against multidrug-resistant Serratia marcescens

et al. 2022

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Serratia marcescens, a Gram-negative bacterium, is one of the known disease-causing pathogens. It is resistant to ampicillin, macrolides, cephalosporins, cefotaxime, and ceftazidime. The only antibiotic that has been proven to be effective against S. marcescens is gentamicin. By causing epigenetic alterations, bacteria can also become resistant to all antibiotics. Many epigenetically related proteins were studied, and four proteins were selected in this regard for epitope evaluation and their subsequent use in the development of a messenger ribonucleic acid (mRNA) vaccine. A series of immune-informatics tools used to build this mRNA vaccine elicited cellular and humoral immunity. Molecular docking between epitopes and alleles of the major histocompatibility complex (MHC) was performed. The vaccine was developed using 37 epitopes, an adjuvant that is a TLR-4 agonist known as resuscitation-promoting factor E (RpfE), subcellular trafficking structures, secretion boosters, and linkers. This proposed architecture was found to cover 99.6% of the population during testing. During testing, it was proven that it was both effective and safe. To confirm our idea, we performed an in silico immunological simulation of vaccination. The codon was also optimized to ensure that the mRNA reached the cytoplasm of a human host and underwent efficient translation. TLR-4 and TLR-3 were also docked against the secondary and tertiary structures of the vaccine peptide. Furthermore, the vaccine's stability was confirmed by molecular dynamics simulation. In summary, this vaccine construct can be a potential candidate against S. marcescens and is suitable for in vitro analyses to validate its effectiveness.

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“…Finally, the development of new vaccines can be the operational response to the unavailability of effective antibiotics for a specific pathogen. 13 …”

Section: Introductionmentioning

confidence: 99%

Available evidence and potential for vaccines for reduction in antibiotic prescriptions

Gabutti¹

2022

Human Vaccines & Immunotherapeutics

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Bacterial antibiotic resistance is a public health issue. It means that drugs become ineffective, infections persist and have a huge impact on the health of patients and their spreading increases. To address a complex threat such as bacterial antibiotic resistance different and integrated approaches are needed including discovery of new antibiotics, improvement of diagnostics tools and improvement of antibiotic stewardship. Absolutely relevant are prevention of infections as well as decrease in the use of antibiotics. Vaccines are an important tool in the fight against bacterial antibiotic resistance and can help prevent it in several ways. Indeed, vaccines are highly effective in preventing diseases that might otherwise require the use of antibiotics to treat symptoms and associated complications. Preventing infections through vaccination helps reduce the need for and widespread and inappropriate use of antibiotics, including for secondary bacterial infections.

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The role of vaccines in combating antimicrobial resistance (AMR) bacteria

Cited by 25 publications

References 81 publications

New Evidence for Artemisia absinthium as an Alternative to Classical Antibiotics: Chemical Analysis of Phenolic Compounds, Screening for Antimicrobial Activity

New Evidence for Artemisia absinthium as an Alternative to Classical Antibiotics: Chemical Analysis of Phenolic Compounds, Screening for Antimicrobial Activity

Evaluation of the whole proteome to design a novel mRNA-based vaccine against multidrug-resistant Serratia marcescens

Available evidence and potential for vaccines for reduction in antibiotic prescriptions

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