The role of vaccination in successful independent ageing

McElhaney, JE; Gavazzi, G.; Flamaing, Johan; Pétermans, Jean

doi:10.1016/j.eurger.2016.01.007

Cited by 10 publications

(12 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings further support the identification by Raison and Miller of single nucleotide polymorphisms in cholinergic-related genes associated with major depression (24)(25)(26)(27)(28) and with the beneficial use of vaccination to reduce inflammation in successful independent aging (29). Recently we found that anxiety (which shares many symptoms with depression) ignites exacerbation of pre-existing neuro-immune risks (5), compatible with our previous reports of co-increasing severity of symptoms, shrinkage of the hippocampus and inflammation biomarkers in patients with post-traumatic stress disorder, who tend to be depressed (30).…”

Section: Discussionsupporting

confidence: 74%

Weakened Cholinergic Blockade of Inflammation Associates with Diabetes-Related Depression

Shenhar‐Tsarfaty

Toker

Shapira

et al. 2016

Mol Med

View full text Add to dashboard Cite

"Melancholia: Fears and despondencies, if they last a long time." -Hippocrates, Aphorisms, Section 6.23Emerging evidence demonstrates association of depression with both immune malfunctioning and worsened course of diverse aging-related diseases, but there is no explanation for the pathway(s) controlling this dual association. Here, we report that in post-reproductive and evolutionarily "blind" years, depression may weaken pathogen-host defense, compatible with the antagonistic pleiotropy hypothesis. In 15,532 healthy volunteers, depression scores associated with both inflammatory parameters and with increased circulation cholinesterase activities, implicating debilitated cholinergic blockade of inflammation as an underlying mechanism; furthermore, depression, inflammation and cholinesterase activities all increased with aging. In the entire cohort, combined increases in inflammation and the diabetic biomarker hemoglobin A1c associated with elevated depression. Moreover, metabolic syndrome patients with higher risk of diabetes showed increased cholinesterase levels and pulse values, and diabetic patients presented simultaneous increases in depression, inflammation and circulation cholinesterase activities, suggesting that cholinergic impairment precedes depression. Our findings indicate that dysfunctioning cholinergic regulation weakens the otherwise protective link between depression and pathogen-host defense, with global implications for aging-related diseases.

show abstract

Section: Discussionsupporting

confidence: 74%

Weakened Cholinergic Blockade of Inflammation Associates with Diabetes-Related Depression

Shenhar‐Tsarfaty

Toker

Shapira

et al. 2016

Mol Med

View full text Add to dashboard Cite

show abstract

“…In conclusion, in addition to age, underlying conditions are an additional burden related to zoster severity and loss of quality of daily life, resulting in slower recovery. With more than 20% of the population of the EU aged 60 years or older, and 80% of people aged 65 years or older having at least one chronic disease, prevention of zoster and PHN in elderly people may contribute to maintenance of their functional status and QOL, and thus to healthy aging ( 39 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of Underlying Conditions on Zoster-Related Pain and on Quality of Life Following Zoster

Torcel-Pagnon

Bricout

Bertrand

et al. 2016

GERONA

View full text Add to dashboard Cite

Background:Chronic conditions have been investigated as risk factors for developing zoster, but in patients suffering from zoster, the impact of underlying conditions in zoster-related pain and quality of life (QOL) remains unclear.Methods:We performed a post hoc analysis of a prospective cohort study in immunocompetent zoster patients aged 50 years or older, conducted by general practitioners in Italy between 2009 and 2010. Zoster symptoms, pain intensity and characteristics, and physical and mental health scores were assessed at baseline (zoster diagnosis) and at 1, 3, and 6 months of follow-up.Results:Among 413 patients enrolled in the study, 73% (303/413) suffered from underlying conditions of which 69% (209/303) were aged 65 or older. Cardiovascular diseases (75%), diabetes (24%), and respiratory diseases (17%) were most frequent. One to three months after onset, zoster patients with underlying conditions experienced more intense zoster-related pain than those without. QOL scores were significantly lower in patients with underlying conditions, and age-adjusted difference in QOL scores between the groups increased over time, demonstrating a slower recovery for patients with underlying conditions.Conclusions:In addition to age, the main risk factor of zoster occurrence and severity, the presence of underlying conditions results in more painful and impactful zoster episodes, creating a significant burden for these patients.

show abstract

“…Of the 40 studies included in our systematic review [ 3 , 4 , 5 , 8 , 10 , 11 , 12 , 13 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ], seven (17.5%) had a non-European perspective and were conducted in Canada ( n = 1) [ 18 ], the USA ( n = 3) [ 19 , 21 , 42 ], China ( n = 1) [ 36 ], Iran ( n = 1) [ 49 ], and low-income countries (LICs) ( n = 1) [ 32 ]; ten (25%) had a global perspective [ 5 , 10 , 12 , 20 , 22 , 24 …”

Section: Resultsmentioning

confidence: 99%

Influenza Vaccination Assessment according to a Value-Based Health Care Approach

et al. 2022

View full text Add to dashboard Cite

Background. Seasonal influenza has a considerable public health impact, and vaccination is the key to preventing its consequences. Our aim was to describe how the value of influenza vaccination is addressed in the scientific literature considering a new value framework based on four pillars (personal, allocative, technical, and societal value). Methods. A systematic review was conducted by querying three databases. The analysis was performed on international studies focused on influenza vaccination value, and the four value pillars were taken into consideration for their description. Results. Overall, 40 studies were considered. Most of them focused on influenza vaccination in the general population (27.5%), emphasizing its value for all age groups. Most studies addressed technical value (70.4%), especially in terms of economic models and cost drivers to be considered for the economic evaluations of influenza vaccines, and societal value (63%), whereas few dealt with personal (37%) and allocative values (22.2%). Conclusions. The whole value of influenza vaccination is still not completely recognized. Knowledge and communication of the whole value of influenza vaccination is essential to guide value-based health policies. To achieve this goal, it is necessary to implement initiatives that involve all relevant stakeholders.

show abstract

The role of vaccination in successful independent ageing

Cited by 10 publications

References 47 publications

Weakened Cholinergic Blockade of Inflammation Associates with Diabetes-Related Depression

Weakened Cholinergic Blockade of Inflammation Associates with Diabetes-Related Depression

Impact of Underlying Conditions on Zoster-Related Pain and on Quality of Life Following Zoster

Influenza Vaccination Assessment according to a Value-Based Health Care Approach

Contact Info

Product

Resources

About