The role of uspE in virulence and biofilm formation by Histophilus somni

Pan, Yu; Subhadra, Bindu; Sandal, Indra; Dickerman, Allan W.; Inzana, Thomas J.

doi:10.1016/j.vetmic.2021.109267

Cited by 7 publications

(7 citation statements)

References 55 publications

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Section: Histophilus Somnimentioning

confidence: 88%

“…The luxS gene encodes an enzyme involved in the biosynthesis of AI-2, a QS small molecule thought to be a universal signaling component in bacteria. However, luxS H. somni mutants showed no impaired biofilm formation compared to a wildtype H. somni strain ( 35 ), suggesting that luxS may not play a role the formation of biofilms by H. somni . Small RNAs (sRNAs) primarily have post-transcriptional gene regulatory functions in bacteria; sRNAs HS9 and HS97 were shown to interact with the transcription factor sigma 54, which may influence biofilm formation and other functions in H. somni ( 23 ).…”

Section: Biofilm Biology In Brd Bacteriamentioning

confidence: 99%

“…Universal stress proteins (Usp) are ubiquitously related to stress responses and adaptation in bacteria. The UspE protein is thought to be a global regulator in H. somni and is associated with biofilm formation, EPS production, and lipooligosaccharide (LOS) truncation ( 35 ). A H. somni mutant strain 2,336::Tn uspE failed to produce biofilms in vitro and was EPS deficient when grown on glass coverslips in well plates ( 35 ).…”

Section: Biofilm Biology In Brd Bacteriamentioning

confidence: 99%

“…The UspE protein is thought to be a global regulator in H. somni and is associated with biofilm formation, EPS production, and lipooligosaccharide (LOS) truncation ( 35 ). A H. somni mutant strain 2,336::Tn uspE failed to produce biofilms in vitro and was EPS deficient when grown on glass coverslips in well plates ( 35 ). Comparative transcriptomics of mutant and wildtype strains grown under planktonic and biofilm states revealed that 181 genes were differentially expressed between the two cell forms.…”

Section: Biofilm Biology In Brd Bacteriamentioning

confidence: 99%

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Role of biofilms in antimicrobial resistance of the bacterial bovine respiratory disease complex

Andrés-Lasheras,

Zaheer,

Jelinski

et al. 2024

Front. Vet. Sci.

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An increase in chronic, non-responsive bovine respiratory disease (BRD) infections in North American feedlot cattle is observed each fall, a time when cattle are administered multiple antimicrobial treatments for BRD. A number of factors are responsible for BRD antimicrobial treatment failure, with formation of biofilms possibly being one. It is widely accepted that biofilms play a role in chronic infections in humans and it has been hypothesized that they are the default lifestyle of most bacteria. However, research on bacterial biofilms associated with livestock is scarce and significant knowledge gaps exist in our understanding of their role in AMR of the bacterial BRD complex. The four main bacterial species of the BRD complex, Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis are able to form biofilms in vitro and there is evidence that at least H. somni retains this ability in vivo. However, there is a need to elucidate whether their biofilm-forming ability contributes to pathogenicity and antimicrobial treatment failure of BRD. Overall, a better understanding of the possible role of BRD bacterial biofilms in clinical disease and AMR could assist in the prevention and management of respiratory infections in feedlot cattle. We review and discuss the current knowledge of BRD bacteria biofilm biology, study methodologies, and their possible relationship to AMR.

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Section: Histophilus Somnimentioning

confidence: 88%

Section: Biofilm Biology In Brd Bacteriamentioning

confidence: 99%

Section: Biofilm Biology In Brd Bacteriamentioning

confidence: 99%

Section: Biofilm Biology In Brd Bacteriamentioning

confidence: 99%

See 2 more Smart Citations

Role of biofilms in antimicrobial resistance of the bacterial bovine respiratory disease complex

Andrés-Lasheras,

Zaheer,

Jelinski

et al. 2024

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…Universal stress proteins (Usp) are ubiquitously related to stress responses and adaptation in bacteria. The UspE protein is thought to be a global regulator in H. somni and is associated with biofilm formation, EPS production, and lipooligosaccharide (LOS) truncation (35). A H. somni mutant strain 2,336::TnuspE failed to produce biofilms in vitro and was EPS deficient when grown on glass coverslips in well plates (35).…”

Section: Histophilus Somnimentioning

confidence: 99%