The role of unfolded protein response in the pathogenesis of endometriosis: contribution of peritoneal fluid

Ekiz-Yılmaz, Tuğba; Işildar, Başak; Gezer, Altay; Kankaya, Duygu; Cansiz-Ersoz, Cevriye; Kayisli, Umit A.; Güzel, Elif

doi:10.1016/j.rbmo.2020.09.012

Cited by 5 publications

(1 citation statement)

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“…This indicated that the UPR cascade reaction was activated in EMS, and the upregulated expression of GRP78 significantly reduced the sensitivity of ectopic endometrial cells to apoptosis and increased their anti-apoptosis ability, which was beneficial for the survival of ectopic endometrial cells. Other UPR proteins, p-IRE1 and p-PERK, were also found increased in endometrial cells when they were treated with peritoneal fluid obtained from women with endometriosis ( 80 ). Taylor ( 81 ) et al.…”

Section: The Role Of Upr In Emsmentioning

confidence: 99%

Hypoxia activates the unfolded protein response signaling network: An adaptive mechanism for endometriosis

Zhou

Jin²,

Wang³

et al. 2022

Front. Endocrinol.

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Endometriosis (EMS) is a chronic gynecological disease that affects women of childbearing age. However, the exact cause remains unclear. The uterus is a highly vascularized organ that continuously exposes endometrial cells to high oxygen concentrations. According to the “planting theory” of EMS pathogenesis, when endometrial cells fall from the uterine cavity and retrograde to the peritoneal cavity, they will face severe hypoxic stress. Hypoxic stress remains a key issue even if successfully implanted into the ovaries or peritoneum. In recent years, increasing evidence has confirmed that hypoxia is closely related to the occurrence and development of EMS. Hypoxia-inducible factor-1α (HIF-1α) can play an essential role in the pathological process of EMS by regulating carbohydrate metabolism, angiogenesis, and energy conversion of ectopic endometrial cells. However, HIF-1α alone is insufficient to achieve the complete program of adaptive changes required for cell survival under hypoxic stress, while the unfolded protein response (UPR) responding to endoplasmic reticulum stress plays an essential supplementary role in promoting cell survival. The formation of a complex signal regulation network by hypoxia-driven UPR may be the cytoprotective adaptation mechanism of ectopic endometrial cells in unfavorable microenvironments.

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Section: The Role Of Upr In Emsmentioning

confidence: 99%