The role of type II collagen fragments and X-ray progression of knee osteoarthritis

Eya, Kazuhiro; Bahlous, Afef; Bouzid, K.; Laadhar, Lilia; Chéour, E.; Sellami, Slaheddine; Abdelmoula, J.; Sahli, H.; Chelly, M

doi:10.1684/abc.2014.1003

Cited by 2 publications

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“…CTX-II, a degradation product of type II collagen, may reflect the degree of articular cartilage damage that has occurred in the early stages of OA [ 27 , 28 ]. Therefore, serum levels of CTX-II were assayed.…”

Section: Resultsmentioning

confidence: 99%

“…In addition to body weight, serum CTX-II levels and type II collagen expression were also assessed to determine the effect of resveratrol on OA. Serum levels of CTX-II have been shown to positively correlate with cartilage degeneration [ 27 , 28 ], and have also been useful as a diagnostic and prognostic biomarker [ 34 ] for evaluating treatment efficacy in knee OA [ 35 ]. In the present study, high doses of resveratrol (45 mg/kg) significantly decreased serum levels of CTX-II, thereby indicating that resveratrol relieved cartilage degradation in mice that received a HFD.…”

Section: Discussionmentioning

confidence: 99%

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Oral Resveratrol Prevents Osteoarthritis Progression in C57BL/6J Mice Fed a High-Fat Diet

et al. 2016

Nutrients

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The effects of resveratrol on osteoarthritis (OA) pathogenesis have been demonstrated in vitro and in animal models employing intra-articular injections. However, the potential for oral resveratrol supplements to mediate protective effects on OA have not been examined. Therefore, the aim of the present study was to investigate the potential anti-OA effects of oral resveratrol on mice fed a high-fat diet (HFD). C57BL/6J male mice were fed either a standard diet or a HFD, and a subset of the latter also received varying doses of resveratrol. Twelve weeks later, all of the animals were sacrificed and knee joints were evaluated with histological, immunohistochemical, and TUNEL analyses. Mice that received a HFD had significantly greater body weights than the control mice and also exhibited features consistent with knee OA. The mice that received a HFD in combination with low, intermediate, or high doses of resveratrol were only slightly heavier than the control mice at the end of 12 weeks. Quantitative histological assessments indicated that resveratrol treatment partly recovered joint structure in the mice that received a HFD, while high doses of resveratrol prevented the degradation of type II collagen into C-telopeptide of type II collagen (CTX-II) and retained type II collagen expression in cartilage. Furthermore, TUNEL analyses revealed a reduction in chondrocyte apoptosis in the resveratrol-treated mice compared with the HFD mice. Thus, oral resveratrol appears to exert anti-OA effects in a mouse model of HFD-induced OA, thereby highlighting the potential preventive and therapeutic value of administering resveratrol for obesity-associated OA.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oral Resveratrol Prevents Osteoarthritis Progression in C57BL/6J Mice Fed a High-Fat Diet

et al. 2016

Nutrients

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Pathological calcification in osteoarthritis: an outcome or a disease initiator?

Yan

Qin

et al. 2020

Biological Reviews

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In the progression of osteoarthritis, pathological calcification in the affected joint is an important feature. The role of these crystallites in the pathogenesis and progression of osteoarthritis is controversial; it remains unclear whether they act as a disease initiator or are present as a result of joint damage. Recent studies reported that the molecular mechanisms regulating physiological calcification of skeletal tissues are similar to those regulating pathological or ectopic calcification of soft tissues. Pathological calcification takes place when the equilibrium is disrupted. Calcium phosphate crystallites are identified in most affected joints and the presence of these crystallites is closely correlated with the extent of joint destruction. These observations suggest that pathological calcification is most likely to be a disease initiator instead of an outcome of osteoarthritis progression. Inhibiting pathological crystallite deposition within joint tissues therefore represents a potential therapeutic target in the management of osteoarthritis.

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The role of type II collagen fragments and X-ray progression of knee osteoarthritis

Cited by 2 publications

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Oral Resveratrol Prevents Osteoarthritis Progression in C57BL/6J Mice Fed a High-Fat Diet

Oral Resveratrol Prevents Osteoarthritis Progression in C57BL/6J Mice Fed a High-Fat Diet

Pathological calcification in osteoarthritis: an outcome or a disease initiator?

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