The role of two common <i>FOXP3</i> gene promoter polymorphisms in preeclampsia in a Turkish population: a case–control study

Çekin, Nilgün; Pınarbaşı, Ergün; Bildirici, Aslihan Esra; Okten, Hatice; Yanık, Ali; Sönmez, Gamze

doi:10.1080/01443615.2019.1634017

Cited by 8 publications

(15 citation statements)

References 25 publications

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“…FOXO3 rs3761548 was also reported as a risk factor to immune-related pregnancy complications [35] and an important contributor for the progression of PE in Iranian women [39]. While no associations between SNP rs3761548 and preeclampsia were found either in Iranian women [40] or the Turkish population [41]. We thought that the conflicting observations were conduced mainly by ethnic and geographic differences.…”

Section: Summary Of Key Resultsmentioning

confidence: 89%

Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study

Pan

Wei

Wang

et al. 2020

BMC Pregnancy Childbirth

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Background Both genetic susceptibility and dysregulated lipid metabolism are important susceptibilities to preeclampsia. In the study, we devote to investigate the associations of FOXO3 and TLR7 genetic polymorphisms with preeclampsia in a Chinese population. Methods This case-control study involved 335 Han Chinese pregnant women, including 177 pregnant women with preeclampsia and 158 healthy controls. The preeclampsia group was further sub-grouped into early-onset preeclampsia (EOPE, n = 70)and late-onset preeclampsia (LOPE, n = 107. Three single nucleotide polymorphisms (SNPs), including FOXO3 (rs2232365, rs3761548), and TLR7 rs3853839 were genotyped by multiplex PCR for targeted next-generation sequencing. The χ2 test and multiple interaction effect analyses were performed to determine the association of three SNPs with serum lipid levels and thyroid function in women with preeclampsia. Results The genotype (CC vs. TT + CT) distribution of rs2232365 revealed a significant association with LOPE (P = 0.004, odds ratio = 3.525 (0.95 CI: 1.498–8.164)). No significant difference was found in the genotype and allele frequencies of rs3761548 and rs3853839 between controls and cases (P > 0.05). Moreover, the genotype CT/TT of rs2232365 was significantly correlated with increased TG/HDL levels in the LOPE group (p = 0.014). Conclusions The polymorphisms of rs2232365 are associated with the risk of LOPE and may modulate TG/HDL levels in pregnant women with LOPE.

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Section: Summary Of Key Resultsmentioning

confidence: 89%

Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study

Pan

Wei

Wang

et al. 2020

BMC Pregnancy Childbirth

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show abstract

“…[32] While no associations between SNP rs3761548 and preeclampsia were found either in Iranian women [33] or the Turkish population. [34] We thought that the con icting observations were conduced mainly by ethnic and geographic differences. Mutation of the genotype of rs3761548 mostly affects the expression and activity of FOXP3 protein, which was further involved in many autoimmune diseases including rheumatoid arthritis, [35] allergic rhinitis, [36]and autoimmune thyroid disease.…”

Section: Discussionmentioning

confidence: 99%

Novel Association Between FOXO3 rs2232365 Polymorphism and Late-Onset Preeclampsia: A Case-Control Candidate Genetic Study

Pan

Wei

Wang

et al. 2020

Preprint

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BackgroundBoth genetic susceptibility and dysregulated lipid metabolism are important susceptibilities to preeclampsia. In the study, we devote to investigate the associations of FOXO3 and TLR7 genetic polymorphisms with preeclampsia in a Chinese population.MethodsThis case-control study involved 335 Han Chinese pregnant women, including 177 pregnant women with preeclampsia and 158 healthy controls. The preeclampsia group was further sub-grouped into early-onset preeclampsia (EOPE, n=70）and late-onset preeclampsia (LOPE, n=107）. Three single nucleotide polymorphisms SNPs , including FOXO3 rs2232365, rs3761548, and TLR7 rs3853839 were genotyped by multiplex PCR for targeted next-generation sequencing. The χ2 test and multiple interaction effect analyses were performed to determine the association of three SNPs with serum lipid levels and thyroid function in women with preeclampsia.ResultsOur study showed that SNP rs2232365 C allele frequencies were significantly associated with the occurrence of LOPE (P=0.022, odds ratio = 1.72 (0.95 CI: 1.23-2.41)). The genotype (CC vs TT+CT) distribution of rs2232365 revealed a significant association with LOPE (P=0.004, odds ratio = 3.497 (0.95 CI: 1.498-8.164)). No significant difference was found in the genotype and allele frequencies of rs3761548 and rs3853839 between controls and cases (P>0.05). Moreover, the genotype CC of rs2232365 was significantly correlated with increased TG/HDL levels in the LOPE group (all p=0.014). ConclusionsThe polymorphisms of rs2232365 are associated with the risk of LOPE and may modulate TG/HDL levels in pregnant women with LOPE.

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“…11,25,26 Recently, growing researches investigated the relationship of FOXP3 polymorphisms with PE risk, among which single nucleotide polymorphisms (SNPs) of -3279C/A (rs3761548), -925A/G (rs2232365), rs4824747, -3499T/C (rs3761547) and IVS9+459T/C (rs2280883) were mostly investigated. [9][10][11][27][28][29][30][31] However, currently available studies did not reach any unanimous conclusions so far. For instance, it was illustrated that FOXP3 rs3761548 was linked to the susceptibility of PE patients.…”

Section: Introductionmentioning

confidence: 99%

“…10,11 In contrast, several other studies revealed that no obvious relationship was found between this SNP and the risk of PE. [27][28][29]31 Furthermore, studies regarding the effects of rs2232365 and rs2280883 polymorphisms on the risk of PE also exhibited inconsistent conclusions. 9,10,27,[29][30][31] Accordingly, there is still a great degree of uncertainty for the definite roles of FOXP3 polymorphisms in PE susceptibility, which requires further exploration and summarization.…”

Section: Introductionmentioning

confidence: 99%

“…[27][28][29]31 Furthermore, studies regarding the effects of rs2232365 and rs2280883 polymorphisms on the risk of PE also exhibited inconsistent conclusions. 9,10,27,[29][30][31] Accordingly, there is still a great degree of uncertainty for the definite roles of FOXP3 polymorphisms in PE susceptibility, which requires further exploration and summarization. However, no such systematic investigation was conducted to our knowledge.…”

Section: Introductionmentioning

confidence: 99%

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Associations of FOXP3 gene polymorphisms with susceptibility and severity of preeclampsia: A meta‐analysis

Fan

Yin³

et al. 2022

American J Rep Immunol

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Objective FOXP3 single nucleotide polymorphisms (SNPs) were recently elucidated to influence the development of preeclampsia (PE), but the results on this issue still remained controversial. Thus, a meta‐analysis was implemented to systematically investigate the roles of FOXP3 SNPs in PE. Methods Eligible publications were identified by retrieving relevant electronic databases. Meanwhile, the association intensity was estimated by calculating odds ratios (ORs) and 95% confidence intervals (CIs) in various genetic models. Results Totally eight investigations involving 3446 subjects were enrolled in the final meta‐analysis. The AC and AC + CC genotypes of FOXP3 rs3761548 were related to the susceptibility of PE in over‐dominant (OR = 1.19, 95%CI = 1.02‐1.38, P = 0.03) and recessive (OR = 0.59, 95% CI: 0.36‐0.97, P = 0.04) models. Furthermore, correlation between rs2232365 and PE was observed in recessive model (GG vs. GA + AA) (OR = 0.79, 95%CI: 0.65‐0.97, P = 0.03). Moreover, rs2232365 GA and GG + GA genotypes were associated with the severity of PE. However, rs4824747, rs3761547 and rs2280883 polymorphisms had no significant impact on PE susceptibility. Conclusions FOXP3 rs3761548 and rs2232365 SNPs influenced the PE susceptibility and therefore may be potential biomarkers for prediction of PE risk.

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The role of two common FOXP3 gene promoter polymorphisms in preeclampsia in a Turkish population: a case–control study

Cited by 8 publications

References 25 publications

Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study

Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study

Novel Association Between FOXO3 rs2232365 Polymorphism and Late-Onset Preeclampsia: A Case-Control Candidate Genetic Study

Associations of FOXP3 gene polymorphisms with susceptibility and severity of preeclampsia: A meta‐analysis

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