The role of tumour-associated MUC1 in epithelial ovarian cancer metastasis and progression

Deng, Jie; Wang, Li; Chen, Hongmin; Li, Lei; Ma, Yiming; Ni, Jie; Li, Yong

doi:10.1007/s10555-013-9423-y

Cited by 70 publications

(63 citation statements)

References 143 publications

(164 reference statements)

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“…ACOX2 up-regulation in the tumor conferred the same protective effect on mortality as MUC1 (mucin 1, cell surface associated 1q21). Variants of MUC1 interact with estrogen [30], and higher expression is associated with late stage epithelial ovarian cancer [31, 32] and prostate cancer [33]. …”

Section: Discussionmentioning

confidence: 99%

Race-associated biological differences among Luminal A breast tumors

D’Arcy

Fleming

Robinson

et al. 2015

Breast Cancer Res Treat

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Purpose African American (AA) women have higher breast-cancer specific mortality rates. A higher prevalence of the worse outcome Basal-like breast cancer subtype contributes to this, but AA women also have higher mortality even within the more favorable outcomes Luminal A breast cancers. These differences may reflect treatment or health care access issues, inherent biological differences, or both. Methods To identify potential biological differences by race among Luminal A breast cancers, gene expression data from 108 CAU and 57 AA breast tumors were analyzed. Race-associated genes were next evaluated for associations with survival. Finally, expression of race- and survival-associated genes was evaluated in normal tissue of AA and CAU women. Results Six genes (ACOX2, MUC1, CRYBB2, PSPH, SQLE, TYMS) were differentially expressed by race among Luminal A breast cancers and were associated with survival (HR < 0.8, HR > 1.25). For all six genes, tumors in AA had higher expression of poor prognosis genes (CRYBB2, PSPH, SQLE, TYMS) and lower expression of good prognosis genes (ACOX2, MUC1). A score based on all six genes predicted survival in a large independent dataset (HR = 1.9 top vs. bottom quartile, 95% CI: 1.4 – 2.5). For four genes, normal tissue of AA and CAU women showed similar expression (ACOX2, MUC1, SQLE, TYMS), however, the poor outcome associated genes CRYBB2 and PSPH were more highly expressed in AA vs. CAU women’s normal tissue. Conclusions This analysis identified gene expression differences that may contribute to mortality disparities and suggests that among Luminal A breast tumors there are biological differences between AA and CAU patients. Some of these differences (CRYBB2 and PSPH) may exist from the earliest stages of tumor development, or even precede malignancy.

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Section: Discussionmentioning

confidence: 99%

Race-associated biological differences among Luminal A breast tumors

D’Arcy

Fleming

Robinson

et al. 2015

Breast Cancer Res Treat

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“…MUC1 is a transmembrane glycoprotein normally expressed on the apical surface of ductal epithelia [7]. However, epithelial adenocarcinomas of several tissues, including breast, prostate, lung, colon, ovary and pancreas tissues, express an aberrant form of MUC1 [8,9]. Active immunotherapy targeting tumors expressing MUC1 could have great value in cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

The immunogenicity and anti-tumor effects of a lung cancer DNA vaccine harboring a MUC-1 and GM-CSF fusion gene

Yang

Jiang

Zhu

et al. 2016

Braz. arch. biol. technol.

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“…An overexpression of MUC4 mRNA has also been reported in OC [86,87] and in an earlier study, it has been shown that MUC4 is aberrantly expressed in >90 % of malignant ovarian tumors with very low to an undetectable expression in the normal ovary [88,89] this suggested MUC4 to have a major role in the pathogenesis of OC. It has been reported that malignant ovarian tumors often express more mucins than benign and borderline ovarian tumors.…”

Section: Ovarian Cancermentioning

confidence: 71%

Exploring the role and diversity of mucins in health and disease with special insight into non-communicable diseases

et al. 2015

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Mucins are major glycoprotein components of the mucus that coats the surfaces of cells lining the respiratory, digestive, gastrointestinal and urogenital tracts. They function to protect epithelial cells from infection, dehydration and physical or chemical injury, as well as to aid the passage of materials through a tract i.e., lubrication. They are also implicated in the pathogenesis of benign and malignant diseases of secretory epithelial cells. In Human there are two types of mucins, membrane-bound and secreted that are originated from mucous producing goblet cells localized in the epithelial cell layer or in mucous producing glands and encoded by MUC gene. Mucins belong to a heterogeneous family of high molecular weight proteins composed of a long peptidic chain with a large number of tandem repeats that form the so-called mucin domain. The molecular weight is generally high, ranging between 0.2 and 10 million Dalton and all mucins contain one or more domains which are highly glycosylated. The size and number of repeats vary between mucins and the genetic polymorphism represents number of repeats (VNTR polymorphisms), which means the size of individual mucins can differ substantially between individuals which can be used as markers. In human it is only MUC1 and MUC7 that have mucin domains with less than 40% serine and threonine which in turn could reduce number of PTS domains. Mucins can be considered as powerful two-edged sword, as its normal function protects from unwanted substances and organisms at an arm's length while, malfunction of mucus may be an important factor in human diseases. In this review we have unearthed the current status of different mucin proteins in understanding its role and function in various non-communicable diseases in human with special reference to its organ specific locations. The findings described in this review may be of direct relevance to the major research area in biomedicine with reference to mucin and mucin associated diseases.

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The role of tumour-associated MUC1 in epithelial ovarian cancer metastasis and progression

Cited by 70 publications

References 143 publications

Race-associated biological differences among Luminal A breast tumors

Race-associated biological differences among Luminal A breast tumors

The immunogenicity and anti-tumor effects of a lung cancer DNA vaccine harboring a MUC-1 and GM-CSF fusion gene

Exploring the role and diversity of mucins in health and disease with special insight into non-communicable diseases

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