The role of tumor neogenesis pipelines in tumor progression and their therapeutic potential

Fu, Zhanqi; Yuan, Yuan

doi:10.1002/cam4.4979

Cited by 11 publications

(6 citation statements)

References 114 publications

(245 reference statements)

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“…Tumours express abundant amounts of HIF, which in turn regulates the vascular endothelial growth factor (VEGF) and the VEGF receptor transcription responsible for new vasculature. 82 Several anticancer therapies target the molecular signalling pathways responsible of the formation of new vessels to decrease oxygen and nutrition supply to tumours, which will eventually lead to the death signal's activation and subsequently killing the cancerous cells. Many known treatments exert their cytotoxic action via these processes, such as Sunitinib inhibitor of VEGF receptor tyrosine kinase activity and Bevacizumab, a selective inhibitor of circulating VEGF used in the treatment of refractory ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

Anticancer activities of tocotrienols: A Systematic Scoping Review

et al. 2023

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Background: The increasing number of cancer cases requires developing newer approaches to treat this disease. One approach uses natural compounds with known anticancer effects, such as tocotrienols. Many cell-based and animal-model studies found that tocotrienols possess potent anticancer activities. However, the exact molecular regulatory mechanism through which tocotrienols exert anticancer actions remains unclear. Methods: This scoping review analysed data from original research articles reporting on the anticancer effects of tocotrienols on human cancer cell lines published in the last seven years (January 2015 and September 2021) using a systematic scoping review approach. From the initial 619 research papers [ProQuest (n= 61), PubMed (n= 84), Embase (n = 148), Ovid Medline (n =53), Scopus (n = 137), Web of Science (n =136)] identified using pre-defined keywords, only 37 articles met the inclusion and exclusion criteria for this review. Human cancers commonly studied in the 37 research articles include breast, lung, prostate and colorectal cancer cell lines. Results: The analysis showed that exposing human cancer cell lines to tocotrienols triggered common anticancer mechanisms such as activation of apoptosis and inhibition of proliferation, angiogenesis and cell migration through regulation of key regulatory genes and proteins involved in these pathways. Conclusions: The findings show that tocotrienols regulate a number of biomarkers that induce cell death and regulate cell cycle in various types of human cancer cells. Further targeted studies are required to map the definite pathways by which T3 exerts their action and to better understand the cellular actions and the regulatory pathways.

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Section: Discussionmentioning

confidence: 99%

Anticancer activities of tocotrienols: A Systematic Scoping Review

et al. 2023

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“…This TGF-rich TME attracts and activates fibroblasts, further promoting tumor invasion [ 128 ]. The SNAI1-SMAD3/4 complex, activated by TGF-β, drives EMT, a key step in metastasis [ 129 ]. Additionally, TGF-β suppresses E-cadherin expression and promotes EMT via TWIST activation [ 130 ].…”

Section: Role Of Hif-1α In Tissue and Matrix Remodelingmentioning

confidence: 99%

A Molecular Perspective on HIF-1α and Angiogenic Stimulator Networks and Their Role in Solid Tumors: An Update

Magar,

Morya,

Kwak

et al. 2024

IJMS

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Hypoxia-inducible factor-1α (HIF-1α) is a major transcriptional factor, which plays an important role in cellular reprogramming processes under hypoxic conditions, which facilitate solid tumors’ progression. HIF-1α is directly involved in the regulation of the angiogenesis, metabolic reprogramming, and extracellular matrix remodeling of the tumor microenvironment. Therefore, an in-depth study on the role of HIF-1α in solid tumor malignancies is required to develop novel anti-cancer therapeutics. HIF-1α also plays a critical role in regulating growth factors, such as the vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor, in a network manner. Additionally, it plays a significant role in tumor progression and chemotherapy resistance by regulating a variety of angiogenic factors, including angiopoietin 1 and angiopoietin 2, matrix metalloproteinase, and erythropoietin, along with energy pathways. Therefore, this review attempts to provide comprehensive insight into the role of HIF-1α in the energy and angiogenesis pathways of solid tumors.

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“…The accumulation of lactic acid and H + is associated with the up-regulation of anaerobic glycolysis during tumorigenesis and the excessive transport of H + from tumor cells to the outside world, leading to the decrease of extracellular pH and the acidic microenvironment in tumor tissues. 150 Therefore, the change of pH can be used as an effective design for cancer diagnosis and treatment. To avoid the quenching effect of dual-mode MRI nanoprobes, releasable dual-mode MRI nanoprobes can be reasonably constructed in a weakly acidic tumor microenvironment.…”

Section: Core-shell Structuresmentioning

confidence: 99%