The Role of Tumor Necrosis Factor-alpha (TNF-α) in Skeletal Muscle Regeneration

Collins, Rachel A.; Grounds, Miranda D.

doi:10.1177/002215540104900807

Cited by 144 publications

(96 citation statements)

References 80 publications

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“…concentrationdependent. Other studies showed that repeated doses from 100 to 500 µg/kg of TNF-α had resulted in muscle protein loss or apoptosis (24,40). That would explain the inability of short pouches to elongate in G.B, as the (41).This note matches with the present study where infiltrated inflammatory cells in the area of tumors and around necrotic tissue were intensely expressed in groupB i.e.…”

Section: -Protective and Promising Myogenic Effect Of Two Thymoquinonsupporting

confidence: 91%

Protective and Promising Myogenic Effect of Two Thymoquinone Formulations In Relation To the Hamster Buccal Pouch-Induced Carcinogenic Model

Hassan¹

2017

IOSR JDMS

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Section: -Protective and Promising Myogenic Effect Of Two Thymoquinonsupporting

confidence: 91%

Protective and Promising Myogenic Effect of Two Thymoquinone Formulations In Relation To the Hamster Buccal Pouch-Induced Carcinogenic Model

Hassan¹

2017

IOSR JDMS

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“…CAME was more effective in suppressing the serum level of TNF-a than indomethacin. TNF-a plays several important roles in inflammation based on its appearance at the inflammatory site and ability to induce certain mechanisms including activation and chemotaxis of leukocytes, expression of adhesion molecules on neutrophils and endothelial cells, and regulation of the secretion of other pro-inflammatory cytokines (Cha et al, 2011;Collins et al, 2001;Park et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect ofCareya arboreaon inflammatory biomarkers in carrageenan-induced inflammation

Begum

Sharma

Pillai

et al. 2014

Pharmaceutical Biology

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Context: Careya arborea Roxb. (Lecythidaceae) has multiple applications in traditional medicine; it exhibits analgesic, antibacterial, anti-inflammatory, antiulcer, and protective effects. However, the effect of C. arborea on biochemical and immmunological inflammatory mediators has not been explored. Objective: The present study investigates the anti-inflammatory potential of the methanol extract of C. arborea stem bark and further assesses its possible mechanism on the modulation of inflammatory biomarkers. Materials and methods: Anti-inflammatory activity of C. arborea methanol extract (CAME) was evaluated (100 and 200 mg/kg, p.o) using indomethacin (10 mg/kg, p.o) as the standard drug in Wistar albino rats. Inflammation was induced by injecting 0.1 ml carrageenan (1% w/v) into the left hind paw. The anti-inflammatory mechanism was studied by measuring malondialdehyde (MDA), C-reactive protein (CRP), nitric oxide (NO), myeloperoxidase (MPO), TNF-a, and IL-1b levels in both control and treated groups. A protocol has also been established to quantify quercetin and betulinic acid content in CAME using HPTLC fingerprint. Results: Careya arborea significantly (p50.001) decreased carrageenan-induced paw edema, showed a reduction of 48.87 and 65.53% at doses of 100 and 200 mg/kg, respectively. Moreover, CAME significantly decreased the MDA, CRP, NO, and MPO levels, elevated by carrageenan induced inflammation. CAME also markedly down-regulated serum TNF-a and IL-1b levels. These findings were further supported by the histological study. The content of quercetin and betulinic acid in CAME was found to be 0.177 and 3.14%, respectively. Conclusion: Several mechanisms, including the inhibition of pro-inflammatory cytokines, enzymes and mediators release, appear to account for the anti-inflammatory potential of C. arborea.

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“…Following muscle injury, the early invading neutrophil and macrophage populations express TNF-␣ (15,137), suggesting that the cytokine may contribute to the early inflammatory stages that precede muscle regeneration. TNF-␣ levels in muscle following acute injury peak at 24 h postinjury, which indicates that TNF-␣ production is most tightly coupled with the Th1 inflammatory response in injured muscle (126).…”

Section: Do Neutrophil-derived or M1 Macrophage-derived Molecules Modmentioning

confidence: 99%

Regulatory interactions between muscle and the immune system during muscle regeneration

Tidball

Villalta

2010

American Journal of Physiology-Regulatory, Integrative and Comp

890

987

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Tidball JG, Villalta SA. Regulatory interactions between muscle and the immune system during muscle regeneration. Am J Physiol Regul Integr Comp Physiol 298: R1173-R1187, 2010. First published March 10, 2010 doi:10.1152/ajpregu.00735.2009.-Recent discoveries reveal complex interactions between skeletal muscle and the immune system that regulate muscle regeneration. In this review, we evaluate evidence that indicates that the response of myeloid cells to muscle injury promotes muscle regeneration and growth. Acute perturbations of muscle activate a sequence of interactions between muscle and inflammatory cells. The initial inflammatory response is a characteristic Th1 inflammatory response, first dominated by neutrophils and subsequently by CD68 ϩ M1 macrophages. M1 macrophages can propagate the Th1 response by releasing proinflammatory cytokines and cause further tissue damage through the release of nitric oxide. Myeloid cells in the early Th1 response stimulate the proliferative phase of myogenesis through mechanisms mediated by TNF-␣ and IL-6; experimental prolongation of their presence is associated with delayed transition to the early differentiation stage of myogenesis. Subsequent invasion by CD163ϩ /CD206 ϩ M2 macrophages attenuates M1 populations through the release of anti-inflammatory cytokines, including IL-10. M2 macrophages play a major role in promoting growth and regeneration; their absence greatly slows muscle growth following injury or modified use and inhibits muscle differentiation and regeneration. Chronic muscle injury leads to profiles of macrophage invasion and function that differ from acute injuries. For example, mdx muscular dystrophy yields invasion of muscle by M1 macrophages, but their early invasion is accompanied by a subpopulation of M2a macrophages. M2a macrophages are IL-4 receptor ϩ /CD206 ϩ cells that reduce cytotoxicity of M1 macrophages. Subsequent invasion of dystrophic muscle by M2c macrophages is associated with progression of the regenerative phase in pathophysiology. Together, these findings show that transitions in macrophage phenotype are an essential component of muscle regeneration in vivo following acute or chronic muscle damage. skeletal muscle; macrophage; neutrophil; muscular dystrophy; chemokines SKELETAL MUSCLE HAS A REMARKABLE capacity for repair, even following severe damage. Experimental findings show that crushing muscle, killing muscle by the injection of toxins, mechanical destruction caused by large, lengthening stretches, or killing muscle fibers by freezing can be followed by the successful regeneration of muscle that leads to recovery of normal structure and function. The regenerative capacity of skeletal muscle relies largely on the presence of a population of mononucleated, myogenic cells, called satellite cells, that retain their ability to proliferate and then differentiate to either fuse with existing fibers or with other myogenic cells to generate new fibers. Thus, perturbations to the processes that normally regulate the activation, proliferat...

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The Role of Tumor Necrosis Factor-alpha (TNF-α) in Skeletal Muscle Regeneration

Cited by 144 publications

References 80 publications

Protective and Promising Myogenic Effect of Two Thymoquinone Formulations In Relation To the Hamster Buccal Pouch-Induced Carcinogenic Model

Protective and Promising Myogenic Effect of Two Thymoquinone Formulations In Relation To the Hamster Buccal Pouch-Induced Carcinogenic Model

Inhibitory effect ofCareya arboreaon inflammatory biomarkers in carrageenan-induced inflammation

Regulatory interactions between muscle and the immune system during muscle regeneration

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