The Role of Translationally Controlled Tumor Protein in Tumor Growth and Metastasis of Colon Adenocarcinoma Cells

Ma, Qiang; Geng, Yan; Xu, Weiwen; Wu, Yanni; He, Fan; Su, Wen Pang; Huang, Mengyi; Du, Hongwu; Li, Ming

doi:10.1021/pr9001367

Cited by 62 publications

(54 citation statements)

References 34 publications

(49 reference statements)

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“…Another proteomics study on colon cancer cells identified 27 proteins, whose levels were altered after TCTP knockdown. In particular, components of ubiquitin-proteasome system and proteins involved in the cytoskeleton were affected under this condition (Ma et al 2010). …”

Section: Tctp In the Regulation Of Protein Degradationmentioning

confidence: 98%

“…4.2.3). Further support comes from a proteomics study on LoVo colon cancer cells reporting that TCTP knockdown results in the alteration predominantly of components of the ubiquitin-proteasome system (Ma et al 2010). 3.…”

Section: Mechanistic Involvement In Cancer Progressionmentioning

confidence: 99%

“…Examples are glioma cells (Jin et al 2015) and a model for liver metastasis in SCID mice (Chan et al 2012a); however the cells most frequently studied in this context are those of colorectal cancer. Knockdown of TCTP inhibited proliferation, migration and invasion activities of LoVo colon cancer cells (Ma et al 2010;Chu et al 2011). Xiao and co-workers reported that in colon cancer patients, TCTP expression levels were higher in liver metastases, compared to primary tumours (Xiao et al 2016).…”

Section: Mechanistic Involvement In Cancer Progressionmentioning

confidence: 99%

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The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

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The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes. It was first discovered about 35 years ago, and it took an extended period of time for its multiple functions to be revealed, and even today we do not yet fully understand all the details. Having witnessed most of this history, in this chapter, I give a brief overview and review the current knowledge on the structure, biological functions, disease involvements and cellular regulation of this protein. TCTP is able to interact with a large number of other proteins and is therefore involved in many core cell biological processes, predominantly in the response to cellular stresses, such as oxidative stress, heat shock, genotoxic stress, imbalance of ion metabolism as well as other conditions. Mechanistically, TCTP acts as an anti-apoptotic protein, and it is involved in DNA-damage repair and in cellular autophagy. Thus, broadly speaking, TCTP can be considered a cytoprotective protein. In addition, TCTP facilitates cell division through stabilising the mitotic spindle and cell growth through modulating growth signalling pathways and through its interaction with the proteosynthetic machinery of the cell. Due to its activities, both as an anti-apoptotic protein and in promoting cell growth and division, TCTP is also essential in the early development of both animals and plants. Apart from its involvement in various biological processes at the cellular level, TCTP can also act as an extracellular protein and as such has been involved in modulating whole-body defence processes, namely in the mammalian immune system. Extracellular TCTP, typically in its dimerised form, is able to induce the release of cytokines and other signalling molecules from various types of immune cells. There are also several examples, where TCTP was shown to be involved in antiviral/antibacterial defence in lower animals. In plants, the protein appears to have a protective effect against phytotoxic stresses, such as flooding, draught, too high or low temperature, salt stress or exposure to heavy metals. The finding for the latter stress condition is corroborated by earlier reports that TCTP levels are considerably up-regulated upon exposure of earthworms to high levels of heavy metals. Given the involvement of TCTP in many biological processes aimed at maintaining cellular or whole-body homeostasis, it is not surprising that dysregulation of TCTP levels may promote a range of disease processes, foremost cancer. Indeed a large body of evidence now supports a role of TCTP in at least the most predominant types of human cancers. Typically, this can be ascribed to both the anti-apoptotic activity of the protein and to its function in promoting cell growth and division. However, TCTP also appears to be involved in the later stages of cancer progression, such ...

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Section: Tctp In the Regulation Of Protein Degradationmentioning

confidence: 98%

Section: Mechanistic Involvement In Cancer Progressionmentioning

confidence: 99%

Section: Mechanistic Involvement In Cancer Progressionmentioning

confidence: 99%

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The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

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“…TCTP protein levels are upregulated in cancer cells and in human tumours (Tuynder et al, 2004;Kim et al, 2008a;Ma et al, 2009;Slaby et al, 2009). Downregulation of TCTP has been implicated in biological models of tumour reversion (Tuynder et al, 2002(Tuynder et al, , 2004, and the protein is the target of various anticancer drugs (Tuynder et al, 2004;Efferth, 2005), of which one has entered a phase-I/II clinical trial (Telerman and Amson, 2009).…”

Section: Introductionmentioning

confidence: 99%

Roles of the translationally controlled tumour protein (TCTP) and the double-stranded RNA-dependent protein kinase, PKR, in cellular stress responses

et al. 2009

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“…22,23 In addition, TCTP has been suggested as a predictive marker for colon adenocarcinoma progression and tumor metastasis. 24 The increased expression of TCTP in FTC versus FA was confirmed by Western blot analysis (Figure 4). Furthermore, the protein DJ-1 was significantly up-regulated in FTC compared with ST (2.5-fold; P Ͻ 0.02; Table 1).…”

Section: Differential Protein Expression In Fa and Ftcmentioning

confidence: 76%

Dissecting Molecular Events in Thyroid Neoplasia Provides Evidence for Distinct Evolution of Follicular Thyroid Adenoma and Carcinoma

Krause¹,

Prawitt²,

Eszlinger³

et al. 2011

The American Journal of Pathology

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Benign hypofunctional cold thyroid nodules (CTNs) are a frequent scintiscan finding and need to be distinguished from thyroid carcinomas. The origin of CTNs with follicular morphologic features is unresolved. The DNA damage response might act as a physiologic barrier, inhibiting the progression of preneoplastic lesions to neoplasia. We investigated the following in hypofunctional follicular adenoma (FA) and follicular thyroid cancer (FTC): i) the mutation rate of frequently activated oncogenes, ii) the activation of DNA damage response checkpoints, and iii) the differential proteomic pattern between FA and FTC. Both FTC and FA, which did not harbor RAS, phosphoinositide-3-kinase, or PAX/peroxisome proliferator activated receptor-␥ mutations, express various proteins in common and others that are more distinctly expressed in FTC rather than in FA or normal thyroid tissue. This finding is in line with the finding of constitutive DNA damage checkpoint activation (p-Chk2, ␥-H2AX) and evidence for replicative stress causing genomic instability (increased cyclin E, retinoblastoma, or E2F1 mRNA expression) in FTC but not FA. We discuss the findings of the increased expression of translationally controlled tumor protein, phosphatase 2A inhibitor, and DJ-1 in FTC compared with FA identified by proteomics and their potential implication in follicular thyroid carcinogenesis. Our present findings argue for the definition of FA as a truly benign entity and against progressive development of FA to FTC.

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The Role of Translationally Controlled Tumor Protein in Tumor Growth and Metastasis of Colon Adenocarcinoma Cells

Cited by 62 publications

References 34 publications

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Roles of the translationally controlled tumour protein (TCTP) and the double-stranded RNA-dependent protein kinase, PKR, in cellular stress responses

Dissecting Molecular Events in Thyroid Neoplasia Provides Evidence for Distinct Evolution of Follicular Thyroid Adenoma and Carcinoma

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