The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain

Hossain, Mohammad Zakir; Bakri, Marina Mohd; Yahya, Farhana; Ando, Hiroshi; Unno, Shumpei

doi:10.3390/ijms20030526

Cited by 58 publications

(70 citation statements)

References 269 publications

(673 reference statements)

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“…Odontoblasts deposit calcium matrix at the outer surface of tooth pulp to form the dentin layer. Due to this anatomical location, the potential secondary role of odontoblasts as a member of the sensory system has been continuously proposed [3,21,22,66,67,68,69,70,71,72,73,74]. The expression of temperature-sensing TRP channels in odontoblasts has been investigated by several researchers, but the results have been diverse.…”

Section: Thermo-sensitive Ion Channelsmentioning

confidence: 99%

“…However, this belief was challenged by multiple observations that pulpal nerves possess physical and chemical properties of large myelinated Aβ fibers. Due to these paradoxical findings, a new concept of “algoneurons” was introduced [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…The structure of the tooth is comprised of densely vascularized and innervated tooth pulp covered by two layers of hard tissue—the dentin and enamel [3,4]. The dentin and enamel are distinguished by their microstructure and mineral content.…”

Section: Introductionmentioning

confidence: 99%

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Ion Channels Involved in Tooth Pain

Lee

Kim

et al. 2019

IJMS

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The tooth has an unusual sensory system that converts external stimuli predominantly into pain, yet its sensory afferents in teeth demonstrate cytochemical properties of non-nociceptive neurons. This review summarizes the recent knowledge underlying this paradoxical nociception, with a focus on the ion channels involved in tooth pain. The expression of temperature-sensitive ion channels has been extensively investigated because thermal stimulation often evokes tooth pain. However, temperature-sensitive ion channels cannot explain the sudden intense tooth pain evoked by innocuous temperatures or light air puffs, leading to the hydrodynamic theory emphasizing the microfluidic movement within the dentinal tubules for detection by mechanosensitive ion channels. Several mechanosensitive ion channels expressed in dental sensory systems have been suggested as key players in the hydrodynamic theory, and TRPM7, which is abundant in the odontoblasts, and recently discovered PIEZO receptors are promising candidates. Several ligand-gated ion channels and voltage-gated ion channels expressed in dental primary afferent neurons have been discussed in relation to their potential contribution to tooth pain. In addition, in recent years, there has been growing interest in the potential sensory role of odontoblasts; thus, the expression of ion channels in odontoblasts and their potential relation to tooth pain is also reviewed.

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Section: Thermo-sensitive Ion Channelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ion Channels Involved in Tooth Pain

Lee

Kim

et al. 2019

IJMS

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“…AEA can also activate TRPV1 channels [40]. TRPV1 is implicated in processing of various types of pain including neuropathic and inflammatory pain [182,[190][191][192]. TRPV1 channels are easily desensitized by TRPV1 agonists (e.g., capsaicin) [193].…”

Section: Modulation Of Endocannabinoids Under Neuropathic Pain Conditmentioning

confidence: 99%

Targeting Peripherally Restricted Cannabinoid Receptor 1, Cannabinoid Receptor 2, and Endocannabinoid-Degrading Enzymes for the Treatment of Neuropathic Pain Including Neuropathic Orofacial Pain

Hossain

Ando

Unno

2020

IJMS

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Neuropathic pain conditions including neuropathic orofacial pain (NOP) are difficult to treat. Contemporary therapeutic agents for neuropathic pain are often ineffective in relieving pain and are associated with various adverse effects. Finding new options for treating neuropathic pain is a major priority in pain-related research. Cannabinoid-based therapeutic strategies have emerged as promising new options. Cannabinoids mainly act on cannabinoid 1 (CB1) and 2 (CB2) receptors, and the former is widely distributed in the brain. The therapeutic significance of cannabinoids is masked by their adverse effects including sedation, motor impairment, addiction and cognitive impairment, which are thought to be mediated by CB1 receptors in the brain. Alternative approaches have been developed to overcome this problem by selectively targeting CB2 receptors, peripherally restricted CB1 receptors and endocannabinoids that may be locally synthesized on demand at sites where their actions are pertinent. Many preclinical studies have reported that these strategies are effective for treating neuropathic pain and produce no or minimal side effects. Recently, we observed that inhibition of degradation of a major endocannabinoid, 2-arachydonoylglycerol, can attenuate NOP following trigeminal nerve injury in mice. This review will discuss the above-mentioned alternative approaches that show potential for treating neuropathic pain including NOP.

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“…bradykinin, prostaglandins), anandamide, arachidonic acid metabolites, lipoxygenase products, adenosine, and ATP [6][7][8][9][10]. TRPV1 plays an important role in transduction of pain under physiological and pathological conditions including neuropathic pain (NP) conditions [11][12][13][14][15][16][17][18][19][20][21]. Immunohistochemical studies revealed that the expression profile of TRPV1 changes under NP conditions [12][13][14][15]17,19].…”

Section: Introductionmentioning

confidence: 99%

A novel approach for detection of functional expression of TRPV1 channels on regenerated neurons following nerve injury

2020

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Transient receptor potential vanilloid 1 (TRPV1) is a polymodal receptor channel, which plays an important role in pain transduction. It is important to understand the functional expression of this channel under neuropathic pain (NP) conditions. A novel method was used to investigate the dynamics of functional expression of this channel on regenerated neurons under NP conditions following trigeminal nerve injury using a combination of a permanently charged sodium channel blocker (QX-314) and a TRPV1 agonist (capsaicin; QX-CAP). The combination was originally introduced as a local anesthetic. Synchronization between the local anesthetic effect of QX-CAP and TRPV1 expression on regenerated neurons was observed following the nerve injury. QX-CAP had no local anesthetic effect under NP conditions 2 weeks after the injury when TRPV1 expression on regenerated neurons was low. However, this combination was effective under NP conditions 3 and 4 weeks following injury when TRPV1 expression in regenerated neurons was moderate to high. The current review, discusses the potential of QX-314 as a local anesthetic and a novel approach of using QX-CAP to reveal the dynamics of functional expression of TRPV1 on regenerated neurons following trigeminal nerve injury.

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The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain

Cited by 58 publications

References 269 publications

Ion Channels Involved in Tooth Pain

Ion Channels Involved in Tooth Pain

Targeting Peripherally Restricted Cannabinoid Receptor 1, Cannabinoid Receptor 2, and Endocannabinoid-Degrading Enzymes for the Treatment of Neuropathic Pain Including Neuropathic Orofacial Pain

A novel approach for detection of functional expression of TRPV1 channels on regenerated neurons following nerve injury

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